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Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity
Neurogastroenterology & Motility, 2007Abstract Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity,
BUENO L. +8 more
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Serotonergic Mechanisms in Myoclonus
1979Post-hypoxic intention myoclonus is a specific myoclonic syndrome in which central serotonergic tone may be deficient. Tryptophan and 5-hydroxytryptophan administration to patients with post-hypoxic intention myoclonus increases pre-existing low levels of 5-hydroxyindoleacetic acid levels in the cerebrospinal bluid, and also suppresses myoclonus ...
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PERIPHERAL SEROTONERGIC SYSTEM IN UREMIA
Thrombosis Research, 1996Several data suggest that platelet-derived serotonin (5-HT), previously classified as a trivial modulator of blood-borne cardiovascular disease (1), may play a decisive role in various pathological processes, resulting from abnormal platelet-vessel wall interactions (2).
D, Pawlak +5 more
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Serotonergic Mediation of Vomiting
Journal of Pediatric Gastroenterology and Nutrition, 1995Summary:In the latter part of the 20th century, significant advances have been made in the understanding of the emetic reflex. As a result, there have been major improvements in the treatment of vomiting, particularly that associated with chemo‐ and radiotherapeutic treatments for neoplastic disease.
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Serotonergic Dysfunction in Depression
British Journal of Psychiatry, 1989Various irregularities in serotonin (5-HT) function have been postulated as causes of affective disorders. Serotonin has been related to many of the major symptoms of depression, e.g. mood, appetite, sleep, activity, and cognitive dysfunction. Interference with 5-HT synthesis or storage has been shown to induce depression in vulnerable individuals ...
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2014
Obsessive-compulsive disorder (OCD) is typically treated with selective serotonin-reuptake inhibitors (SSRIs), cognitive behavioral therapy (CBT), or both. The neurobiological effects of these treatments that are associated with symptom improvement, however, remain unclear.
Jennifer I. Lissemore +5 more
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Obsessive-compulsive disorder (OCD) is typically treated with selective serotonin-reuptake inhibitors (SSRIs), cognitive behavioral therapy (CBT), or both. The neurobiological effects of these treatments that are associated with symptom improvement, however, remain unclear.
Jennifer I. Lissemore +5 more
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Multimodal serotonergic antidepressants
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2017Based on the original literature, the author for the first time describes a history of selective serotonergic antidepressants simultaneously inhibiting the serotonin reuptake and directly interacting with serotonin receptors. A history of creation and introduction of their main representatives is presented.
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Serotonergic mechanisms in aggression.
Novartis Foundation symposium, 2005The serotonergic system in the CNS has complex interactions with many, if not all other neurotransmitter systems in the brain. Its localization, distribution and amazing receptor diversity makes it an appealing system for modulatory aspects in many basic behaviours, including food and water intake, sexual behaviour and aggression.
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2010
Abstract This chapter discusses current knowledge of the pharmacology and physiology of the feedback mechanisms that control serotonin (5-hydroxytryptamine; 5-HT) neurons, and considers their possible contribution to the pathophysiology and treatment of psychiatric disorders, especially major depression.
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Abstract This chapter discusses current knowledge of the pharmacology and physiology of the feedback mechanisms that control serotonin (5-hydroxytryptamine; 5-HT) neurons, and considers their possible contribution to the pathophysiology and treatment of psychiatric disorders, especially major depression.
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