Results 1 to 10 of about 10,132 (232)

Noradrenergic dysfunction in Alzheimer's disease [PDF]

Frontiers in Neuroscience, 2015
The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout the brain via widespread efferent projections, and plays a pivotal role in modulating cognitive activities in the cortex.
Mary Gannon, Yunjia Chen, Kai Jiao
exaly   +6 more sources

A mechanism linking perinatal 2,3,7,8 tetrachlorodibenzo-p-dioxin exposure to lower urinary tract dysfunction in adulthood

Disease Models & Mechanisms, 2021
Benign prostatic hyperplasia/lower urinary tract dysfunction (LUTD) affects nearly all men. Symptoms typically present in the fifth or sixth decade and progressively worsen over the remainder of life. Here, we identify a surprising origin of this disease
Anne E. Turco, Steven R. Oakes, Kimberly P. Keil Stietz, Cheryl L. Dunham, Diya B. Joseph, Thrishna S. Chathurvedula, Nicholas M. Girardi, Andrew J. Schneider, Joseph Gawdzik, Celeste M. Sheftel, Peiqing Wang, Zunyi Wang, Dale E. Bjorling, William A. Ricke, Weiping Tang, Laura L. Hernandez, Janet R. Keast, Adrian D. Bonev, Matthew D. Grimes, Douglas W. Strand, Nathan R. Tykocki, Robyn L. Tanguay, Richard E. Peterson, Chad M. Vezina   +23 more
doaj   +1 more source

Perioperative Sedation and Sympatholysis Due to Tizanidine [PDF]

Journal of Clinical and Diagnostic Research, 2020
Tizanidine is a short acting central muscle relaxant. It has agonist activity at noradrenergic alpha 2 receptors and inhibits the excitatory (presynaptic) motor neurons at both the spinal and supraspinal levels.
Situ, Girish Kumar Singh, Hari Haran Gnaneswaran   +2 more
doaj   +1 more source

Depression and/or PTSD Comorbidity Affects Response to Antidepressants in Those With Alcohol Use Disorder

Frontiers in Psychiatry, 2022
Objective: Depression and post-traumatic stress disorder (PTSD) highly co-occur with alcohol use disorder (AUD). The comparative effects of noradrenergic vs.
Peter J. Na, Peter J. Na, Elizabeth Ralevski, Elizabeth Ralevski, Oluwole Jegede, Aaron Wolfgang, Ismene L. Petrakis, Ismene L. Petrakis   +7 more
doaj   +1 more source

Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population

Frontiers in Neurology, 2022
ObjectiveAge-related decline within the noradrenergic system is associated with reduced cognition. The β-adrenoceptors are widely expressed in the brain as well as in the peripheral.
Shishuang Cui, Shishuang Cui, Fang Fang, Fang Fang, Peijing Cui, Peijing Cui, Qianwen Jiang, Qianwen Jiang, Shaoqing Xu, Shaoqing Xu, Zhihong Xu, Zhihong Xu, Jia'An Hu, Jia'An Hu, Feika Li, Feika Li   +15 more
doaj   +1 more source

The modulation effects of repeated transcutaneous auricular vagus nerve stimulation on the functional connectivity of key brainstem regions along the vagus nerve pathway in migraine patients

Frontiers in Molecular Neuroscience, 2023
BackgroundPrevious studies have shown a significant response to acute transcutaneous vagus nerve stimulation (taVNS) in regions of the vagus nerve pathway, including the nucleus tractus solitarius (NTS), raphe nucleus (RN) and locus coeruleus (LC) in ...
Yiting Huang, Yue Zhang, Sierra Hodges, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Thalia Chai-Zhang, Jian Kong, Bo Liu   +10 more
doaj   +1 more source

A single dose of noradrenergic/serotonergic reuptake inhibitors combined with an antimuscarinic does not improve obstructive sleep apnoea severity

Physiological Reports, 2022
Previous trials have demonstrated that the combination of noradrenergic reuptake inhibitors with an antimuscarinic can substantially reduce the apnoea‐hypopnoea index (AHI) and improve airway collapsibility in patients with obstructive sleep apnoea (OSA).
Luke D. J. Thomson, Shane A. Landry, Simon A. Joosten, Dwayne L. Mann, Ai‐Ming Wong, Tim Cheung, Mulki Adam, Caroline J. Beatty, Garun S. Hamilton, Bradley A. Edwards   +9 more
doaj   +1 more source

Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles

Frontiers in Molecular Biosciences, 2023
Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This
Rachel A. Matt, Frederick G. Westhorpe, Rosemary F. Romuar, Payal Rana, Joel R. Gever, Anthony P. Ford   +5 more
doaj   +1 more source

Satiation and stress-induced hypophagia: examining the role of hindbrain neurons expressing prolactin-releasing peptide (PrRP) or glucagon-like peptide 1 (GLP-1)

Frontiers in Neuroscience, 2013
Neural circuits distributed within the brainstem, hypothalamus, and limbic forebrain interact to control food intake and energy balance under normal day-to-day conditions, and in response to stressful conditions under which homeostasis is threatened ...
James W. Maniscalco, Alison D. Kreisler, Linda eRinaman   +2 more
doaj   +1 more source

Analgesic Effects of Bee Venom Derived Phospholipase A2 in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain

Toxins, 2015
A single infusion of oxaliplatin, which is widely used to treat metastatic colorectal cancer, induces specific sensory neurotoxicity signs that are triggered or aggravated when exposed to cold or mechanical stimuli.
Dongxing Li, Younju Lee, Woojin Kim, Kyungjin Lee, Hyunsu Bae, Sun Kwang Kim   +5 more
doaj   +1 more source