Results 1 to 10 of about 74,045 (223)

Genetic Activation of Locus Coeruleus Noradrenergic Neurons Modulates Cerebellar MF-GrC Synaptic Plasticity via Presynaptic α2-AR/PKA Signaling in Mice [PDF]

Biology
Locus coeruleus (LC) noradrenergic neurons project their axons to the cerebellar cortex and modulate cerebellar circuit function via distinct adrenergic receptor (AR) subtypes.
Ying-Han Xu, Xu-Dong Zhang, Yang Liu, Zhi-Zhi Zhao, Yuan Zheng, De-Lai Qiu, Chun-Ping Chu   +6 more
doaj   +2 more sources

Noradrenergic system involvement as a major driver of tension-type headache: a systematic review of the current evidence [PDF]

The Journal of Headache and Pain
Background Tension-type headache (TTH) is the most prevalent primary headache disorder, affecting individuals of all ages and imposing a substantial global burden.
Simone Braca, Gennaro Cretella, Christina Deligianni, Laura Kennelly, Vasilis-Spyridon Tseriotis, Anna P. Andreou, Dimos-Dimitrios Mitsikostas, Theodoros Mavridis   +7 more
doaj   +2 more sources

Noradrenergic innervation across brain regions is altered by aging and by disease progression in a mouse model of Alzheimer's disease neuropathology. [PDF]

PLoS ONE
Norepinephrine plays critical roles in modulating arousal and attention, is highly dynamic in awake, behaving individuals, and has anti-inflammatory and neuroprotective actions.
Nicole M Hernandez, Manuel Silva-Pérez, Jeannie Chin   +2 more
doaj   +2 more sources

Dopaminergic and Noradrenergic Contributions to Divergent and Convergent Creativity Task Performance, a Systematic Review [PDF]

Behavioral Sciences
A range of factors affect performance on tasks associated with creativity, including stress, pharmacology, behavioral interventions, and neural stimulation strategies. Most of the pharmacological impacts have focused on the dopaminergic and noradrenergic
David Q. Beversdorf
doaj   +2 more sources

Deep brain stimulation of medial forebrain bundle modulates noradrenergic activity and feedforward inhibition in rodent model of depression [PDF]

Translational Psychiatry
Deep Brain Stimulation (DBS) of the superolateral medial forebrain bundle has shown promising long-term anti-depressant effects in treatment-resistant depression patients, although the mechanisms are not clear.
Zhuo Duan, Yixin Tong, Volker A. Coenen, Máté D. Döbrössy   +3 more
doaj   +2 more sources

A mechanism linking perinatal 2,3,7,8 tetrachlorodibenzo-p-dioxin exposure to lower urinary tract dysfunction in adulthood

Disease Models & Mechanisms, 2021
Benign prostatic hyperplasia/lower urinary tract dysfunction (LUTD) affects nearly all men. Symptoms typically present in the fifth or sixth decade and progressively worsen over the remainder of life. Here, we identify a surprising origin of this disease
Anne E. Turco, Steven R. Oakes, Kimberly P. Keil Stietz, Cheryl L. Dunham, Diya B. Joseph, Thrishna S. Chathurvedula, Nicholas M. Girardi, Andrew J. Schneider, Joseph Gawdzik, Celeste M. Sheftel, Peiqing Wang, Zunyi Wang, Dale E. Bjorling, William A. Ricke, Weiping Tang, Laura L. Hernandez, Janet R. Keast, Adrian D. Bonev, Matthew D. Grimes, Douglas W. Strand, Nathan R. Tykocki, Robyn L. Tanguay, Richard E. Peterson, Chad M. Vezina   +23 more
doaj   +1 more source

Perioperative Sedation and Sympatholysis Due to Tizanidine [PDF]

Journal of Clinical and Diagnostic Research, 2020
Tizanidine is a short acting central muscle relaxant. It has agonist activity at noradrenergic alpha 2 receptors and inhibits the excitatory (presynaptic) motor neurons at both the spinal and supraspinal levels.
Situ, Girish Kumar Singh, Hari Haran Gnaneswaran   +2 more
doaj   +1 more source

Depression and/or PTSD Comorbidity Affects Response to Antidepressants in Those With Alcohol Use Disorder

Frontiers in Psychiatry, 2022
Objective: Depression and post-traumatic stress disorder (PTSD) highly co-occur with alcohol use disorder (AUD). The comparative effects of noradrenergic vs.
Peter J. Na, Peter J. Na, Elizabeth Ralevski, Elizabeth Ralevski, Oluwole Jegede, Aaron Wolfgang, Ismene L. Petrakis, Ismene L. Petrakis   +7 more
doaj   +1 more source

Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population

Frontiers in Neurology, 2022
ObjectiveAge-related decline within the noradrenergic system is associated with reduced cognition. The β-adrenoceptors are widely expressed in the brain as well as in the peripheral.
Shishuang Cui, Shishuang Cui, Fang Fang, Fang Fang, Peijing Cui, Peijing Cui, Qianwen Jiang, Qianwen Jiang, Shaoqing Xu, Shaoqing Xu, Zhihong Xu, Zhihong Xu, Jia'An Hu, Jia'An Hu, Feika Li, Feika Li   +15 more
doaj   +1 more source

The modulation effects of repeated transcutaneous auricular vagus nerve stimulation on the functional connectivity of key brainstem regions along the vagus nerve pathway in migraine patients

Frontiers in Molecular Neuroscience, 2023
BackgroundPrevious studies have shown a significant response to acute transcutaneous vagus nerve stimulation (taVNS) in regions of the vagus nerve pathway, including the nucleus tractus solitarius (NTS), raphe nucleus (RN) and locus coeruleus (LC) in ...
Yiting Huang, Yue Zhang, Sierra Hodges, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Thalia Chai-Zhang, Jian Kong, Bo Liu   +10 more
doaj   +1 more source