Results 1 to 10 of about 62,612 (160)

Noradrenergic dysfunction in Alzheimer's disease

Frontiers in Neuroscience, 2015
The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout the brain via widespread efferent projections, and plays a pivotal role in modulating cognitive activities in the cortex.
Mary Gannon, Qin Wang, Erik Robérson
exaly   +4 more sources

Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma

Nature Communications, 2023
Noradrenergic and mesenchymal cell states have been proposed in neuroblastoma, but their contributions to the tumour are not clearly understood.
C. Thirant, A. Peltier, Simon Durand, Amira Kramdi, Caroline Louis-Brennetot, Cecile Pierre-Eugene, Marguerite Gautier, Ana Costa, A. Grelier, Sakina Zaïdi, N. Gruel, I. Jimenez, E. Lapouble, G. Pierron, Déborah Sitbon, H. Brisse, A. Gauthier, P. Fréneaux, Sandrine Grossetête, L. Baudrin, V. Raynal, S. Baulande, Angela Bellini, J. Bhalshankar, A. Carcaboso, B. Geoerger, Hermann Rohrer, D. Surdez, V. Boeva, G. Schleiermacher, O. Delattre, I. Janoueix-Lerosey   +31 more
semanticscholar   +2 more sources

The Noradrenergic System in Parkinson’s Disease

Frontiers in Pharmacology, 2020
Nowadays it is well accepted that in Parkinson’s disease (PD), the neurodegenerative process occurs in stages and that damage to other areas precedes the neuronal loss in the substantia nigra pars compacta, which is considered a pathophysiological ...
Elena Paredes-Rodriguez, Sergio Vegas‐Suárez, T. Morera-Herreras, P. De Deurwaerdère, C. Miguélez   +4 more
semanticscholar   +3 more sources

Genetic Activation of Locus Coeruleus Noradrenergic Neurons Modulates Cerebellar MF-GrC Synaptic Plasticity via Presynaptic α2-AR/PKA Signaling in Mice. [PDF]

Biology (Basel)
Locus coeruleus (LC) noradrenergic neurons project their axons to the cerebellar cortex and modulate cerebellar circuit function via distinct adrenergic receptor (AR) subtypes.
Xu YH, Zhang XD, Liu Y, Zhao ZZ, Zheng Y, Qiu DL, Chu CP.   +6 more
europepmc   +2 more sources

Noradrenergic system involvement as a major driver of tension-type headache: a systematic review of the current evidence. [PDF]

J Headache Pain
Background Tension-type headache (TTH) is the most prevalent primary headache disorder, affecting individuals of all ages and imposing a substantial global burden.
Braca S, Cretella G, Deligianni C, Kennelly L, Tseriotis VS, Andreou AP, Mitsikostas DD, Mavridis T.   +7 more
europepmc   +2 more sources

Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies

Frontiers in Aging Neuroscience, 2018
Noradrenergic dysfunction contributes to cognitive impairment in Alzheimer's Disease (AD) and Parkinson's Disease (PD). Conventional therapeutic strategies seek to enhance cholinergic and dopaminergic neurotransmission in AD and PD, respectively, and few
Andrew C. Peterson, C. Li
semanticscholar   +3 more sources

The noradrenergic paradox: implications in the management of depression and anxiety

Neuropsychiatric Disease and Treatment, 2016
Both major depressive disorder and the anxiety disorders are major causes of disability and markedly contribute to a significant global burden of the disease worldwide.
A. Montoya, R. Bruins, M. Katzman, P. Blier   +3 more
semanticscholar   +3 more sources

Noradrenergic innervation across brain regions is altered by aging and by disease progression in a mouse model of Alzheimer's disease neuropathology. [PDF]

PLoS One
Norepinephrine plays critical roles in modulating arousal and attention, is highly dynamic in awake, behaving individuals, and has anti-inflammatory and neuroprotective actions.
Hernandez NM, Silva-Pérez M, Chin J.
europepmc   +2 more sources

Noradrenergic dysregulation in the pathophysiology of PTSD

Experimental Neurology, 2016
Rebecca Hendrickson, Murray A Raskind
exaly   +2 more sources

Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex

bioRxiv, 2023
Fluctuations in brain and behavioral state are supported by broadly projecting neuromodulatory systems. In this study, we use mesoscale two-photon calcium imaging to examine spontaneous activity of cholinergic and noradrenergic axons in awake mice in ...
L. Collins, J. Francis, B. Emanuel, D. McCormick   +3 more
semanticscholar   +1 more source