Results 21 to 30 of about 62,748 (289)
Frontiers in Molecular Biosciences, 2023 Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This
Rachel A. Matt +5 more
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Frontiers in Neuroscience, 2013 Neural circuits distributed within the brainstem, hypothalamus, and limbic forebrain interact to control food intake and energy balance under normal day-to-day conditions, and in response to stressful conditions under which homeostasis is threatened ...
James W. Maniscalco +2 more
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Toxins, 2015 A single infusion of oxaliplatin, which is widely used to treat metastatic colorectal cancer, induces specific sensory neurotoxicity signs that are triggered or aggravated when exposed to cold or mechanical stimuli.
Dongxing Li +5 more
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Frontiers in Molecular Neuroscience, 2023 SLITRK1 is a neuronal transmembrane protein with neurite development-and synaptic formation-controlling abilities. Several rare variants of SLITRK1 have been identified and implicated in the pathogenesis of Tourette’s syndrome, trichotillomania, and ...
Minoru Hatayama, Jun Aruga
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Frontiers in Neurology, 2018 The Autism Spectrum Disorders (ASD) are a heterogeneous group of developmental disorders. Although, ASD can be reliably diagnosed, the etiology, pathophysiology, and treatment targets remain poorly characterized. While there are many atypical findings in
Eric B. London
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Noradrenergic modulation of arousal [PDF]
Brain Research Reviews, 2008 Through a highly divergent efferent projection system, the locus coeruleus-noradrenergic system supplies norepinephrine throughout the central nervous system. State-dependent neuronal discharge activity of locus coeruleus neurons has long-suggested a role of this system in the induction of an alert waking state.
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Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan
Journal of Neuroscience, 2020 Selectively attending to relevant information while blocking out distractors is crucial for goal-directed behavior, yet with advancing age, deficits emerge in attentional selectivity.
M. Dahl +3 more
semanticscholar +1 more source
PTSD: from neurobiology to pharmacological treatments
European Journal of Psychotraumatology, 2016 Posttraumatic stress disorder (PTSD) is a chronic debilitating psychiatric disorder characterized by symptoms of re-experience, avoidance, and hyperarousal that can arise immediately or many years after exposure to a traumatic event and injury.
Benjamin Kelmendi +5 more
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Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Brain : a journal of neurology, 2019 The locus coeruleus is the site of the earliest pathological changes in many neurodegenerative diseases. Betts et al. describe how in vivo locus coeruleus imaging can be used as a biomarker for noradrenergic dysfunction in neurodegenerative diseases, and
M. Betts +41 more
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Loss of Sympathetic Nerves in Spleens from Patients with End Stage Sepsis
Frontiers in Immunology, 2017 The spleen is an important site for central regulation of immune function by noradrenergic sympathetic nerves, but little is known about this major region of neuroimmune communication in humans.
Donald B. Hoover +7 more
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