Discriminating depression, physical and social anhedonia by neurotransmitter related challenge tests [PDF]
The aim of this study was to investigate, if anhedonia, a salient component of depression, shows similar response patterns to neurotransmitter challenge tests as depression, and if the two questionnaire based components Physical (PA) and Social (SA ...
Hennig, Juergen, Netter, Petra
core +2 more sources
Sex-dependent noradrenergic modulation of premotor cortex during decision-making
Rodent premotor cortex (M2) integrates information from sensory and cognitive networks for action planning during goal-directed decision-making. M2 function is regulated by cortical inputs and ascending neuromodulators, including norepinephrine (NE ...
Ellen M Rodberg +3 more
doaj +1 more source
Neurobiological Mechanisms That Contribute to Stress-related Cocaine Use [PDF]
The ability of stressful life events to trigger drug use is particularly problematic for the management of cocaine addiction due to the unpredictable and often uncontrollable nature of stress.
Ahmed +149 more
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Comorbid Tourette’s and Bipolar Disorders
Of 205 patients with Tourette’s disorder in the North Dakota Longitudinal Tourette Syndrome Surveillance Project, 15 had comorbid bipolar disorder.
J Gordon Millichap
doaj +1 more source
The inhibition of the dorsal paragigantocellular reticular nucleus induces waking and the activation of all adrenergic and noradrenergic neurons: a combined pharmacological and functional neuroanatomical study. [PDF]
GABAergic neurons specifically active during paradoxical sleep (PS) localized in the dorsal paragigantocellular reticular nucleus (DPGi) are known to be responsible for the cessation of activity of the noradrenergic neurons of the locus coeruleus during ...
Olivier Clément +5 more
doaj +1 more source
Preclinical discovery of duloxetine for the treatment of depression [PDF]
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María +4 more
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Gulf War Syndrome: A role for organophosphate induced plasticity of locus coeruleus neurons [PDF]
Gulf War syndrome is a chronic multi-symptom illness that has affected about a quarter of the deployed veterans of the 1991 Gulf War. Exposure to prolonged low-level organophosphate insecticides and other toxic chemicals is now thought to be responsible.
Andrew L. Varnell +2 more
core +3 more sources
Simulation of Cholinergic and Noradrenergic Modulation of Behavior in Uncertain Environments
Attention is a complex neurobiological process that involves rapidly and flexibly balancing sensory input and goal-directed predictions in response to environmental changes.
Michael C Avery +4 more
doaj +1 more source
Neuropsychological correlates of opioid dependence and withdrawal [PDF]
Severity of opioid dependence, and performance on two successive runs of the Wisconsin Card Sorting Test (WCST), were assessed in 39 right-handed male and female methadone patients who had been randomly assigned to either a recently dosed (n=21) or 24 hr
Lyvers, Michael, Yakimoff, Michael
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Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract
The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age ...
Shai Porat +10 more
doaj +1 more source

