Results 31 to 40 of about 10,132 (232)
Simulation of Cholinergic and Noradrenergic Modulation of Behavior in Uncertain Environments
Frontiers in Computational Neuroscience, 2012 Attention is a complex neurobiological process that involves rapidly and flexibly balancing sensory input and goal-directed predictions in response to environmental changes.
Michael C Avery +4 more
doaj +1 more source
Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract
NeuroImage, 2022 The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age ...
Shai Porat +10 more
doaj +1 more source
Noradrenergic Source of Dopamine Assessed by Microdialysis in the Medial Prefrontal Cortex
Frontiers in Pharmacology, 2020 Previous results indicate that dopamine (DA) release in the medial prefrontal cortex (mPFC) is modified by α2 adrenoceptor- but not D2 DA receptor- agonists and antagonists, suggesting that DA measured by microdialysis in the mPFC originates from ...
Paola Devoto +9 more
doaj +1 more source
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION Despite advances in disease‐modifying drugs, better treatments for symptomatic Alzheimer's disease (AD) are needed, with dopaminergic neurotransmission representing a potential target.
Cristina Bonet Olivares +5 more
doaj +1 more source
SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex
Communications Biology, 2022 Loss of SLITRK1 results in altered behaviour and in increased noradrenergic projections in OCD-related neural circuits, suggesting that differences in noradrenergic signaling may contribute to numerous neurodevelopmental disorders, including OCD ...
Minoru Hatayama +9 more
doaj +1 more source
eLife, 2023 In a constantly changing environment, organisms must track the current relationship between actions and their specific consequences and use this information to guide decision-making.
Juan Carlos Cerpa +7 more
doaj +1 more source
Noradrenergic modulation of stress resilience
Pharmacological Research, 2023 Resilience represents an active adaption process in the face of adversity, trauma, tragedy, threats, or significant sources of stress. Investigations of neurobiological mechanisms of resilience opens an innovative direction for preclinical research and drug development for various stress-related disorders.
Xiaojing, Zhai +4 more
openaire +2 more sources
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source
Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Narcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin‐4 (AQP4 ...
Jonas Ranke +5 more
wiley +1 more source
Role of noradrenergic arousal for fear generalization
, 2020 We wanted to investigate what influence acute stress has on later fear generalization and specifically if noradrenergic arousal is necessary for the possible stress effects to ...
Franziska Magdalena Kausche
core +4 more sources