Results 41 to 50 of about 62,748 (289)
Noradrenergic neuromodulation in ageing and disease
Neuroscience & Biobehavioral Reviews, 2023 The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates cognition and autonomic functions and is involved in the brain's immune response.
Krohn, F +9 more
openaire +4 more sources
Noradrenergic Modulation of Cognition in Health and Disease
Journal of Neural Transplantation and Plasticity, 2017 Norepinephrine released by the locus coeruleus modulates cellular processes and synaptic transmission in the central nervous system through its actions at a number of pre- and postsynaptic receptors.
O. Borodovitsyna +2 more
semanticscholar +1 more source
Simulation of Cholinergic and Noradrenergic Modulation of Behavior in Uncertain Environments
Frontiers in Computational Neuroscience, 2012 Attention is a complex neurobiological process that involves rapidly and flexibly balancing sensory input and goal-directed predictions in response to environmental changes.
Michael C Avery +4 more
doaj +1 more source
Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System
International Journal of Molecular Sciences, 2019 Gabapentinoids (gabapentin and pregabalin) and antidepressants (tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors) are often used to treat chronic pain.
Ken-ichiro Hayashida, H. Obata
semanticscholar +1 more source
Magnetic resonance imaging of noradrenergic neurons
Brain Structure and Function, 2019 Noradrenaline is a neurotransmitter involved in general arousal, selective attention, memory, inflammation, and neurodegeneration. The purpose of this work was to delineate noradrenergic neurons in vivo by T1-weighted MRI with magnetization transfer (MT).
Takashi Watanabe +4 more
semanticscholar +1 more source
Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract
NeuroImage, 2022 The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age ...
Shai Porat +10 more
doaj +1 more source
Noradrenergic Modulation of Fear Conditioning and Extinction
Frontiers in Behavioral Neuroscience, 2018 The locus coeruleus norepinephrine (LC-NE) system plays a broad role in learning and memory. Here we begin with an overview of the LC-NE system. We then consider how both direct and indirect manipulations of the LC-NE system affect cued and contextual ...
Thomas F. Giustino, Stephen Maren
semanticscholar +1 more source
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION Despite advances in disease‐modifying drugs, better treatments for symptomatic Alzheimer's disease (AD) are needed, with dopaminergic neurotransmission representing a potential target.
Cristina Bonet Olivares +5 more
doaj +1 more source
Noradrenergic modulation of stress resilience
Pharmacological Research, 2023 Resilience represents an active adaption process in the face of adversity, trauma, tragedy, threats, or significant sources of stress. Investigations of neurobiological mechanisms of resilience opens an innovative direction for preclinical research and drug development for various stress-related disorders.
Xiaojing, Zhai +4 more
openaire +2 more sources
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source