Results 41 to 50 of about 74,045 (223)
Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling. [PDF]
, 2015 Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning.
Alessandra Ghigo +10 more
core +1 more source
Locus coeruleus complex of the family Delphinidae [PDF]
, 2018 The locus coeruleus (LC) is the largest catecholaminergic nucleus and extensively projects to widespread areas of the brain and spinal cord. The LC is the largest source of noradrenaline in the brain.
Arbelo, Manuel +6 more
core +2 more sources
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsINTRODUCTION Despite advances in disease‐modifying drugs, better treatments for symptomatic Alzheimer's disease (AD) are needed, with dopaminergic neurotransmission representing a potential target.
Cristina Bonet Olivares +5 more
doaj +1 more source
Noradrenergic dysfunction in Alzheimer’s disease
Frontiers in Neuroscience, 2015 The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout the brain via widespread efferent projections, and plays a pivotal role in modulating cognitive activities in the cortex.
Mary eGannon +5 more
doaj +1 more source
Noradrenergic Source of Dopamine Assessed by Microdialysis in the Medial Prefrontal Cortex
Frontiers in Pharmacology, 2020 Previous results indicate that dopamine (DA) release in the medial prefrontal cortex (mPFC) is modified by α2 adrenoceptor- but not D2 DA receptor- agonists and antagonists, suggesting that DA measured by microdialysis in the mPFC originates from ...
Paola Devoto +9 more
doaj +1 more source
eLife, 2023 In a constantly changing environment, organisms must track the current relationship between actions and their specific consequences and use this information to guide decision-making.
Juan Carlos Cerpa +7 more
doaj +1 more source
Parkinson's disease dementia: a neural networks perspective. [PDF]
, 2015 In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more ...
Foltynie, T, Gratwicke, J, Jahanshahi, M
core +1 more source
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source
SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex
Communications Biology, 2022 Loss of SLITRK1 results in altered behaviour and in increased noradrenergic projections in OCD-related neural circuits, suggesting that differences in noradrenergic signaling may contribute to numerous neurodevelopmental disorders, including OCD ...
Minoru Hatayama +9 more
doaj +1 more source
Differences in peripheral noradrenergic function among actively drinking and abstinent alcohol-dependent individuals. [PDF]
, 2004 We examined whether excessive alcohol consumption was related to changes in plasma levels of noradrenaline (NA) and whether these changes recover following abstinence.
Gopalakrishnan, Raman +6 more
core +1 more source