Results 51 to 60 of about 62,748 (289)

Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors

Brain Structure and Function, 2019
Accumulating evidence indicates that disruption of galanin signaling is associated with neuropsychiatric disease, but the precise functions of this neuropeptide remain largely unresolved due to lack of tools for experimentally disrupting its transmission
Rachel P. Tillage, Natale R. Sciolino, N. W. Plummer, D. Lustberg, L. C. Liles, M. Hsiang, Jeanne M. Powell, Kathleen G. Smith, Patricia Jensen, D. Weinshenker   +9 more
semanticscholar   +1 more source

Noradrenergic Source of Dopamine Assessed by Microdialysis in the Medial Prefrontal Cortex

Frontiers in Pharmacology, 2020
Previous results indicate that dopamine (DA) release in the medial prefrontal cortex (mPFC) is modified by α2 adrenoceptor- but not D2 DA receptor- agonists and antagonists, suggesting that DA measured by microdialysis in the mPFC originates from ...
Paola Devoto, Paola Devoto, Claudia Sagheddu, Michele Santoni, Giovanna Flore, Pierluigi Saba, Marco Pistis, Marco Pistis, Gian Luigi Gessa, Gian Luigi Gessa   +9 more
doaj   +1 more source

SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex

Communications Biology, 2022
Loss of SLITRK1 results in altered behaviour and in increased noradrenergic projections in OCD-related neural circuits, suggesting that differences in noradrenergic signaling may contribute to numerous neurodevelopmental disorders, including OCD ...
Minoru Hatayama, Kei-ichi Katayama, Yukie Kawahara, Hayato Matsunaga, Noriko Takashima, Yoshimi Iwayama, Yoshifumi Matsumoto, Akinori Nishi, Takeo Yoshikawa, Jun Aruga   +9 more
doaj   +1 more source

Inhibition of noradrenergic signalling in rodent orbitofrontal cortex impairs the updating of goal-directed actions

eLife, 2023
In a constantly changing environment, organisms must track the current relationship between actions and their specific consequences and use this information to guide decision-making.
Juan Carlos Cerpa, Alessandro Piccin, Margot Dehove, Marina Lavigne, Eric J Kremer, Mathieu Wolff, Shauna L Parkes, Etienne Coutureau   +7 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Molecular and Functional Sex Differences of Noradrenergic Neurons in the Mouse Locus Coeruleus

Cell Reports, 2018
SUMMARY Preclinical work has long focused on male animals, though biological sex clearly influences risk for certain diseases, including many psychiatric disorders.
Bern Mulvey, Dionnet L. Bhatti, S. Gyawali, A. Lake, S. Kriaučionis, C. P. Ford, M. Bruchas, N. Heintz, J. Dougherty   +8 more
semanticscholar   +1 more source

Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus

Biomolecules, 2020
Noncompetitive N-methyl-D-aspartate/glutamate receptor (NMDAR) antagonists contribute to the pathophysiology of schizophrenia and mood disorders but improve monoaminergic antidepressant-resistant mood disorder and suicidal ideation. The mechanisms of the
Motohiro Okada, Kouji Fukuyama
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

CRH engagement of the locus coeruleus noradrenergic system mediates stress-induced anxiety

Neuron, 2015
Summary The locus coeruleus noradrenergic (LC-NE) system is one of the first systems engaged following a stressful event. While numerous groups have demonstrated that LC-NE neurons are activated by many different stressors, the underlying neural ...
J. McCall, R. Al-Hasani, E. Siuda, Daniel Y. Hong, Aaron J. Norris, C. P. Ford, M. Bruchas   +6 more
semanticscholar   +1 more source