Results 11 to 20 of about 62,748 (289)

COPPER AND THE BRAIN NORADRENERGIC SYSTEM

JBIC Journal of Biological Inorganic Chemistry, 2019
Copper (Cu) plays an essential role in the development and function of the brain. In humans, genetic disorders of Cu metabolism may cause either severe Cu deficiency (Menkes disease) or excessive Cu accumulation (Wilson disease) in the brain tissue.
S. Lutsenko, Clorissa L Washington-Hughes, M. Ralle, Katharina Schmidt   +3 more
semanticscholar   +4 more sources

A mechanism linking perinatal 2,3,7,8 tetrachlorodibenzo-p-dioxin exposure to lower urinary tract dysfunction in adulthood

Disease Models & Mechanisms, 2021
Benign prostatic hyperplasia/lower urinary tract dysfunction (LUTD) affects nearly all men. Symptoms typically present in the fifth or sixth decade and progressively worsen over the remainder of life. Here, we identify a surprising origin of this disease
Anne E. Turco, Steven R. Oakes, Kimberly P. Keil Stietz, Cheryl L. Dunham, Diya B. Joseph, Thrishna S. Chathurvedula, Nicholas M. Girardi, Andrew J. Schneider, Joseph Gawdzik, Celeste M. Sheftel, Peiqing Wang, Zunyi Wang, Dale E. Bjorling, William A. Ricke, Weiping Tang, Laura L. Hernandez, Janet R. Keast, Adrian D. Bonev, Matthew D. Grimes, Douglas W. Strand, Nathan R. Tykocki, Robyn L. Tanguay, Richard E. Peterson, Chad M. Vezina   +23 more
doaj   +1 more source

Perioperative Sedation and Sympatholysis Due to Tizanidine [PDF]

Journal of Clinical and Diagnostic Research, 2020
Tizanidine is a short acting central muscle relaxant. It has agonist activity at noradrenergic alpha 2 receptors and inhibits the excitatory (presynaptic) motor neurons at both the spinal and supraspinal levels.
Situ, Girish Kumar Singh, Hari Haran Gnaneswaran   +2 more
doaj   +1 more source

Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing.

Neuroscience and Biobehavioral Reviews, 2023
Noradrenergic and cholinergic systems are among the most vulnerable brain systems in neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease, Lewy body dementia, and progressive supranuclear palsy.
I. Orlando, J. Shine, T. Robbins, J. Rowe, C. O’Callaghan   +4 more
semanticscholar   +1 more source

Noradrenergic circuit control of non-REM sleep substates

bioRxiv, 2021
One promising approach towards understanding what makes sleep vulnerable in disease is to look at how wake-promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity is inhibited during non-REM sleep (NREMS).
A. Osorio-Forero, Romain Cardis, Gil Vantomme, Aurélie Guillaume-Gentil, Georgia Katsioudi, Laura M. J. Fernandez, A. Lüthi   +6 more
semanticscholar   +1 more source

Depression and/or PTSD Comorbidity Affects Response to Antidepressants in Those With Alcohol Use Disorder

Frontiers in Psychiatry, 2022
Objective: Depression and post-traumatic stress disorder (PTSD) highly co-occur with alcohol use disorder (AUD). The comparative effects of noradrenergic vs.
Peter J. Na, Peter J. Na, Elizabeth Ralevski, Elizabeth Ralevski, Oluwole Jegede, Aaron Wolfgang, Ismene L. Petrakis, Ismene L. Petrakis   +7 more
doaj   +1 more source

Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer’s disease: systematic review and meta-analysis

Journal of Neurology Neurosurgery & Psychiatry, 2022
Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease, contributing to cognitive and neuropsychiatric symptoms in some patients.
Michael C B David, M. Del Giovane, Kathy Y. Liu, Benjamin Gostick, J. Rowe, Imafidon Oboh, R. Howard, P. Malhotra   +7 more
semanticscholar   +1 more source

Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population

Frontiers in Neurology, 2022
ObjectiveAge-related decline within the noradrenergic system is associated with reduced cognition. The β-adrenoceptors are widely expressed in the brain as well as in the peripheral.
Shishuang Cui, Shishuang Cui, Fang Fang, Fang Fang, Peijing Cui, Peijing Cui, Qianwen Jiang, Qianwen Jiang, Shaoqing Xu, Shaoqing Xu, Zhihong Xu, Zhihong Xu, Jia'An Hu, Jia'An Hu, Feika Li, Feika Li   +15 more
doaj   +1 more source

The modulation effects of repeated transcutaneous auricular vagus nerve stimulation on the functional connectivity of key brainstem regions along the vagus nerve pathway in migraine patients

Frontiers in Molecular Neuroscience, 2023
BackgroundPrevious studies have shown a significant response to acute transcutaneous vagus nerve stimulation (taVNS) in regions of the vagus nerve pathway, including the nucleus tractus solitarius (NTS), raphe nucleus (RN) and locus coeruleus (LC) in ...
Yiting Huang, Yue Zhang, Sierra Hodges, Hui Li, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Thalia Chai-Zhang, Jian Kong, Bo Liu   +10 more
doaj   +1 more source

A single dose of noradrenergic/serotonergic reuptake inhibitors combined with an antimuscarinic does not improve obstructive sleep apnoea severity

Physiological Reports, 2022
Previous trials have demonstrated that the combination of noradrenergic reuptake inhibitors with an antimuscarinic can substantially reduce the apnoea‐hypopnoea index (AHI) and improve airway collapsibility in patients with obstructive sleep apnoea (OSA).
Luke D. J. Thomson, Shane A. Landry, Simon A. Joosten, Dwayne L. Mann, Ai‐Ming Wong, Tim Cheung, Mulki Adam, Caroline J. Beatty, Garun S. Hamilton, Bradley A. Edwards   +9 more
doaj   +1 more source