Results 261 to 270 of about 234,379 (321)

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni   +5 more
wiley   +1 more source

THE ROLE OF SEROTONIN IN CARBOHYDRATE METABOLISM IV

open access: bronze, 1960
Michio Ui   +2 more
openalex   +2 more sources

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra   +3 more
wiley   +1 more source

Cpx‐mediated amino acid sensing diversifies gastrointestinal colonization of Klebsiella pneumoniae

open access: yesmLife, EarlyView.
Abstract Klebsiella pneumoniae is a Gram‐negative opportunistic pathogenic bacterium that occasionally inhabits the human gastrointestinal tracts. Gut‐colonized K. pneumoniae may then metastasize to other organs and tissues, thus causing severe infections. In this study, we identified three cpxA mutations in K. pneumoniae that experimentally evolved to
Danyang Li   +8 more
wiley   +1 more source

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