Results 11 to 20 of about 25,888 (267)

Neural signaling mechanisms in depression: bridging classical monoamine hypotheses, animal models, and emerging antidepressant strategies [PDF]

Frontiers in Cell and Developmental Biology
Major depressive disorder is a highly prevalent psychiatric condition that can affect individuals across the lifespan, yet its pathophysiology remains incompletely understood. Classical hypotheses, informed by preclinical and clinical studies, emphasized
Mizuki Yamamoto, Haruka Hirakata, Koji Toda   +2 more
doaj   +2 more sources

Risk of Thrombocytopenia by SSRIs or SNRIs in Patients With Depression Based on MID‐NET: A Cohort Study in Japan [PDF]

Clinical and Translational Science
Risk assessment on thrombocytopenia by selective serotonin reuptake inhibitors (SSRIs) or serotonin noradrenaline reuptake inhibitors (SNRIs) is limited. An observational study with cohort design was conducted based on the MID‐NET for evaluating the risk
Yusuke Okada, Kazuhiro Kajiyama, Maki Komamine, Takashi Ando, Tomoaki Hasegawa, Chieko Ishiguro, Takahiro Nonaka, Mariko Tsukuda, Yukari Iwasaki, Takahiro Ueda, Naoya Horiuchi, Toyotaka Iguchi, Yoshiaki Uyama   +12 more
doaj   +2 more sources

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Multidisciplinary treatment of the patient with a severe irritable bowel syndrome [PDF]

Терапевтический архив, 2020
The patient E., aged 39, was described with a severe form of the irritable bowel syndrome that developed after the stress. In addition to the clinical manifestations of IBS, the patient got the somatoform disorders, which manifested itself with a large ...
I. N. Ruchkina, A. A. Vyaznikova, L. K. Indeykina, D. A. Degterev, A. I. Parfenov   +4 more
doaj   +1 more source

Preclinical discovery of duloxetine for the treatment of depression [PDF]

, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María, Elorza, Julián, Micó Segura, Juan Antonio, Perez-Caballero, Laura, Torres-Sanchez, Sonia   +4 more
core   +2 more sources

Antidepressant-induced sexual dysfunction

South African Family Practice, 2009
Depression and sexual dysfunction are both common in the general population. When they co-exist, they have the potential to impact negatively on each other in a bidirectional manner.
Kim Outhoff
doaj   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Duloxetine-induced rapid eye movement sleep behavior disorder: a case report

BMC Psychiatry, 2017
Background Tricyclic antidepressants and selective serotonin reuptake inhibitors have been reported to induce the symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) or to exacerbate REM sleep without atonia.
Lu Tan, Junying Zhou, Linghui Yang, Rong Ren, Ye Zhang, Taomei Li, Xiangdong Tang   +6 more
doaj   +1 more source

Experimental Pharmacological Research Regarding the Potential Antidepressant Activity Induced by Some Newly Synthesised Dibenzo[a,d]cycloheptene Compounds [PDF]

, 2015
Background. Depression is a relatively frequent encountered mental disorder in the general population, affecting both the quality of the individual life and its ability to perform the social tasks; it is generally accepted that new studies related to ...
Junghină, Adrian, Păunică, Ioana, Scutari, Corina, Ștefănescu, Emil   +3 more
core   +4 more sources

Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) [PDF]

, 2012
Antidepressants that block the reuptake of serotonin (5-HT) and noradrenaline (NA) are called 5-HT and NA reuptake inhibitors (SNRIs). SNRIs are agents that show “dual action” on 5-HT and NA. These drugs bind the 5-HT transporters (SERT) and NA transporters (NAT) similar to tricyclic antidepressants (TCAs). However, SNRIs differ from TCAs in that SNRIs
Ipek Komsuoglu, Oguz Mutlu, Guner Ulak
openaire   +1 more source