Results 231 to 240 of about 25,888 (267)

Combination Treatment with Noradrenalin and Serotonin Reuptake Inhibitors in Resistant Depression

British Journal of Psychiatry, 1992
Eight cases of resistant recurrent depression were treated with a combination of nortriptyline and a new serotonin reuptake inhbitor, with or without concurrent lithium therapy. Significant improvement was seen in all patients where other drug regimes and ECT had been ineffective. No adverse reactions occurred in any of our patients, seven of whom were
R, Seth, A L, Jennings, J, Bindman, J, Phillips, K, Bergmann   +4 more
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Antidepressant Properties of Specific Serotonin—Noradrenaline Reuptake Inhibitors

1997
Despite 30 yr of intensive research and development of antidepressant drugs, about 30% of patients do not respond satisfactorily to treatment, and no antidepressant starts to produce its therapeutic effect in less than 2–3 wk. Although considerable progress has been made in improving the tolerability of antidepressant drugs, the tricyclic ...
Michael Briley, Chantal Moret
openaire   +1 more source

Evaluation of akathisia in patients receiving selective serotonin reuptake inhibitors/serotonin and noradrenaline reuptake inhibitors

Behavioural Pharmacology
Akathisia is an underestimated but disturbing extrapyramidal side effect of antidepressants, which could reduce treatment compliance in mood disorders. This study aimed to investigate the frequency and risk factors in patients treated with selective serotonin reuptake inhibitors/serotonin and noradrenaline reuptake inhibitors (SSRI/SNRI).
Ismail, Akgoz, Huseyin, Kara, Ozgen, Ozcelik, Levent, Donmez, Mehmet, Eryilmaz, Gul, Ozbey   +5 more
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Serotonin and noradrenaline reuptake inhibitors in animal models of pain

Human Psychopharmacology: Clinical and Experimental, 2004
Animal models of chronic pain serve as an experimental basis for testing new therapeutic interventions and for mechanistic investigations. In an animal model of chronic pain, based on the injection of formalin into the paw of a rodent, inhibitors of noradrenaline reuptake such as nisoxetine, nortriptyline and maprotiline and dual inhibitors of the ...
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Reuptake Inhibitors of Dopamine, Noradrenaline, and Serotonin

2011
Pharmacological inhibition of monoamine reuptake transporters has been known for many years as an effective therapy to reduce food intake and body weight in obese subjects. However, most of the marketed drugs failed after a distinct period in clinical use and had to be withdrawn because of serious adverse effects resulting in a negative benefit-risk ...
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Serotonin, noradrenaline and cognitive function: a preliminary investigation of the acute pharmacodynamic effects of a serotonin versus a serotonin and noradrenaline reuptake inhibitor

Behavioral Pharmacology, 2000
Comparisons of the behavioural side-effect profiles of antidepressants that inhibit either serotonin or both serotonin and noradrenaline reuptake, may reveal differences in cognitive and psychomotor functions, which may be attributed to their relative pharmacological selectivity for potentiating monoamine neurotransmission in the central nervous system.
Nathan, Pradeep J., Siteram, Geetha, Stough, Con, Silberstein, Richard B., Avni, Sali   +4 more
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Milnacipran, a new serotonin and noradrenaline reuptake inhibitor

International Clinical Psychopharmacology, 1997
Milnacipran (Ixel) is a new antidepressant with essentially equal potency for inhibiting the reuptake of both serotonin and noradrenaline, with no affinity for any neurotransmitter receptor studied. A review of the studies comparing milnacipran, placebo and active comparator antidepressants provides clear-cut evidence of its efficacy in both severe and
A, Puech, S A, Montgomery, J F, Prost, A, Solles, M, Briley   +4 more
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Serotonin noradrenaline reuptake inhibitors: Logical evolution of antidepressant development

International Journal of Psychiatry in Clinical Practice, 2006
Although considerable progress has been made in improving the tolerability of antidepressant drugs, the classical tricyclic antidepressants (TCA) are still a standard for efficacy. The selective serotonin reuptake inhibitors (SSRI) are much better tolerated than the TCAs, but their antidepressant efficacy is, at best, equivalent and probably inferior ...
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Duloxetine: A new serotonin/noradrenaline reuptake inhibitor for the treatment of depression

Drugs of Today, 2004
Double-blind, placebo-controlled clinical trials have evaluated and demonstrated the efficacy of duloxetine as an antidepressant in patients with major depressive disorders. The drug has been noted to be well tolerated and effective in the control of depressive symptoms.
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Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats

Psychopharmacology, 2002
The prefrontal cortex is implicated in the pathophysiology of depression, and hypoactivity of this brain area has been found in depressed patients. Reduced function of the serotonergic and noradrenergic systems is another feature of depression.The present study was aimed at characterizing neurochemically and behaviorally the serotonin and noradrenaline
Daisuke, Mochizuki, Ryuichi, Tsujita, Shinji, Yamada, Koh, Kawasaki, Yuji, Otsuka, Shinji, Hashimoto, Tsuyoshi, Hattori, Yoshihisa, Kitamura, Naomasa, Miki   +8 more
openaire   +2 more sources