Results 261 to 270 of about 143,694 (316)
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Serotonin and serotonin receptors in the central auditory system
Otolaryngology–Head and Neck Surgery, 1994Immunohistochemical and ligand‐binding techniques were used to visualize the neurotransmitter serotonin and one of its receptors, the 5‐HT1A subtype, in auditory nuclei of the brainstem. Serotonergic fibers and terminal endings were found in all auditory nuclei extending from the cochlear nucleus to the inferior colliculus, including the superior ...
G C, Thompson +3 more
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Molecular Biology Of Serotonin Receptors
Annual Review of Neuroscience, 1991Serotonin (S-hydroxytryptamine; SHT) is a biogenic amine that functions as both a neurotransmitter and a hormone in the mammalian central nervous system (CNS) and in the periphery. Within the brain, serotonergic neurons originate primarily in the raphe nuclei of the brainstem and project to most areas of the CNS, where they regulate a wide variety of ...
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Serotonin receptor sensitivity and aggression
Psychiatry Research, 1991This study investigated the relationship between increased serotonin (5-hydroxytryptamine, 5HT) receptor sensitivity and human aggression. A low oral dose of meta-chlorophenylpiperazine (MCPP), a postsynaptic 5HT receptor agonist, was administered in a placebo-controlled design to depressed (n = 22) and panic disorder (n = 20) patients classified with ...
S, Wetzler +4 more
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Serotonin Receptors in Rat Lung
Respiration, 2009Mammalian lungs have been shown to store and to inactivate serotonin by an active process involving uptake and metabolism. Serotonin has direct action on lung including constrictor effects of pulmonary vascular and tracheobronchial smooth muscle suggesting the presence of serotonin receptors in lung.
D K, Das, H, Steinberg
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2002
Abstract The pharmacology of serotonin (5-hydroxytryptamine; 5-HT) was reviewed in 1986 (Bradley et al .) acknowledging the existence of at least three 5-HT receptor families: 5-HT1–3. In the 15 years following this classification molecular cloning has confirmed the existence of multiple 5-HT receptors subtypes.
Claire Roberts +2 more
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Abstract The pharmacology of serotonin (5-hydroxytryptamine; 5-HT) was reviewed in 1986 (Bradley et al .) acknowledging the existence of at least three 5-HT receptor families: 5-HT1–3. In the 15 years following this classification molecular cloning has confirmed the existence of multiple 5-HT receptors subtypes.
Claire Roberts +2 more
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Oligomerization of Dopamine and Serotonin Receptors
Neuropsychopharmacology, 2000Until recently, it has largely been assumed that G protein-coupled receptors (GPCRs) function as monomeric entities. However, over the past few years, we and others have documented that GPCRs can form dimers and oligomers, leading to a re-evaluation of the mechanisms thought to mediate GPCR function.
S P, Lee +5 more
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Serotonin and Serotonin Receptors in Hallucinogen Action
2010Abstract Hallucinogens (psychedelics) are substances that induce profound changes in perception and cognition. The closely related 3,4-methylenedioxymethamphetamine (MDMA) produces euphoria and a feeling of empathy, with minimal sensory distortion. Both of these classes of substances produce their effects by interacting with the serotonergic system ...
Adam L. Halberstadt, David E. Nichols
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Serotonin receptors: Clinical implications
Neuroscience & Biobehavioral Reviews, 1990Over the past decade, a variety of serotonin (5-hydroxytryptamine, 5-HT) receptor/binding sites have been identified. These include 5-HT1, 5-HT2, and 5-HT3 sites. The 5-HT1 sites have been further divided into 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT1E sites.
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Serotonin receptors-where are they going?
International Clinical Psychopharmacology, 1994Thirty-three years ago, Gaddum and Picarelli classified the serotonin (5-HT) receptors in the guinea-pig ileum into D and M types based on the activity of dibenzyline (D) and morphine (M) to block contractions of intestinal smooth muscles caused by 5-HT.
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