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Serotonin and serotonin receptors in the central auditory system
Otolaryngology–Head and Neck Surgery, 1994Immunohistochemical and ligand‐binding techniques were used to visualize the neurotransmitter serotonin and one of its receptors, the 5‐HT1A subtype, in auditory nuclei of the brainstem. Serotonergic fibers and terminal endings were found in all auditory nuclei extending from the cochlear nucleus to the inferior colliculus, including the superior ...
G C, Thompson +3 more
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1993
The fact that nearly all known serotonin receptor subtypes are single subunit proteins, members of the same gene superfamily (the G protein-coupled receptor or 7TM superfamily) and that most are intronless genes has helped accelerate the cloning of this receptor family.
P R, Hartig +7 more
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The fact that nearly all known serotonin receptor subtypes are single subunit proteins, members of the same gene superfamily (the G protein-coupled receptor or 7TM superfamily) and that most are intronless genes has helped accelerate the cloning of this receptor family.
P R, Hartig +7 more
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Molecular Biology Of Serotonin Receptors
Annual Review of Neuroscience, 1991Serotonin (S-hydroxytryptamine; SHT) is a biogenic amine that functions as both a neurotransmitter and a hormone in the mammalian central nervous system (CNS) and in the periphery. Within the brain, serotonergic neurons originate primarily in the raphe nuclei of the brainstem and project to most areas of the CNS, where they regulate a wide variety of ...
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Drugs affecting serotonin receptors
Baillière's Clinical Gastroenterology, 1994A greater understanding of the various serotonin receptor subtypes has led to a clearer appreciation of the role of serotonin in gastrointestinal motility, sensation and secretion. Serotonin is definitely involved in the aetiopathogenesis of cisplatin-induced emesis and carcinoid diarrhoea. The application of serotonergic drugs in clinical therapeutics
M, Camilleri, M R, Von der Ohe
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2002
Abstract The pharmacology of serotonin (5-hydroxytryptamine; 5-HT) was reviewed in 1986 (Bradley et al .) acknowledging the existence of at least three 5-HT receptor families: 5-HT1–3. In the 15 years following this classification molecular cloning has confirmed the existence of multiple 5-HT receptors subtypes.
Claire Roberts +2 more
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Abstract The pharmacology of serotonin (5-hydroxytryptamine; 5-HT) was reviewed in 1986 (Bradley et al .) acknowledging the existence of at least three 5-HT receptor families: 5-HT1–3. In the 15 years following this classification molecular cloning has confirmed the existence of multiple 5-HT receptors subtypes.
Claire Roberts +2 more
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Serotonin and Serotonin Receptors in Hallucinogen Action
2010Abstract Hallucinogens (psychedelics) are substances that induce profound changes in perception and cognition. The closely related 3,4-methylenedioxymethamphetamine (MDMA) produces euphoria and a feeling of empathy, with minimal sensory distortion. Both of these classes of substances produce their effects by interacting with the serotonergic system ...
Adam L. Halberstadt, David E. Nichols
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Serotonin receptors-where are they going?
International Clinical Psychopharmacology, 1994Thirty-three years ago, Gaddum and Picarelli classified the serotonin (5-HT) receptors in the guinea-pig ileum into D and M types based on the activity of dibenzyline (D) and morphine (M) to block contractions of intestinal smooth muscles caused by 5-HT.
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Serotonin receptors in brain revisited
Brain Research, 2016In the early 1980's, the dispute on the existence of a multiplicity of receptors for neurotransmitter was at its height. Several subtypes of serotonin (5-HT) receptors were proposed on the basis of radioligand binding assays. In order to provide further support to the existence of these receptors we performed quantitative autoradiographic mapping of ...
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Serotonin receptors: Clinical implications
Neuroscience & Biobehavioral Reviews, 1990Over the past decade, a variety of serotonin (5-hydroxytryptamine, 5-HT) receptor/binding sites have been identified. These include 5-HT1, 5-HT2, and 5-HT3 sites. The 5-HT1 sites have been further divided into 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT1E sites.
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