Results 221 to 230 of about 40,021 (309)

Caffeine and Headache: Exploring the Multifaceted Relationship

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Purpose To explore the multifaceted relationship between caffeine and headache disorders, focusing on its dual role as both an analgesic and a potential trigger and to summarize the mechanisms underlying its anti‐nociceptive effects. Method This narrative review synthesizes evidence from experimental, clinical, and epidemiological studies on ...
Mona Hussein, Amr Hassan, Salsabil Abo Al‐Azayem, Janu Thuraiaiyah, Henrik Winther Schytz, Anter Mothenna Abdullah Nasser, Rehab Magdy   +6 more
wiley   +1 more source

G Protein-Coupled Receptors in Irritable Bowel Syndrome: Mechanisms and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Zhu Z, Liu Z, He Y, He X, Zheng W, Jiang M.   +5 more
europepmc   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

The evolving landscape of primary headache therapy. [PDF]

Neurotherapeutics
Holland PR, Goadsby PJ.
europepmc   +1 more source

Sentience in cephalopod molluscs: an updated assessment

Biological Reviews, Volume 101, Issue 3, Page 1311-1333, June 2026.
ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell, Heather Browning, Andrew Crump, Charlotte C. Burn, Jonathan Birch   +4 more
wiley   +1 more source

Idiopathic Granulomatous Mastitis in a Nulliparous Woman With Autism Spectrum Disorder Receiving Long‐Term Psychotropic Treatment and Normal Serum Prolactin Level: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disorder, primarily attributed to immunological dysregulation, hormonal imbalances, or fertility‐related conditions. We report a 26‐year‐old female with autism spectrum disorder (ASD) under long‐term multidrug psychotropic treatment who developed IGM.
Esmat Davoudi‐Monfared, Fatemeh Shahabi, Asieh Sadat Fattahi, Marzieh Rahimi, Mahsa Akbari Oryani, Azadeh Jabbari Nooghabi   +5 more
wiley   +1 more source

Mechanisms and clinical implications of gut-brain interactions. [PDF]

J Clin Invest
Lorsch ZS, Liddle RA.
europepmc   +1 more source

Consensus on the Clinical Use of Pregabalin in Peripheral Neuropathic Pain

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Pregabalin, a second‐generation α2δ calcium‐channel ligand, exerts potent analgesic effects in peripheral neuropathic pain by reducing calcium influx, suppressing excitatory neurotransmitter release, and decreasing neuronal hyperexcitability. Based on a PRISMA‐guided review of 139 studies and multidisciplinary expert consensus, pregabalin demonstrates ...
Hui Lu, Yuefeng Rao, Jian Wang, Wan Shuanglin, Du Dongping, Ma Ke, Zhiying Feng, Suming Tian, Weidong Qiu, Xu Jing, Zhongwei zhao, Zhenhua Zeng, Benyan Luo, Changqing Wang, Hui Zhao, Kaiming Liu, Li Lin, Xianfeng Zhang, Gong Liyan, Haiqi Lu, Yan Liu, Qingwei Zhao, Yihe Hu   +22 more
wiley   +1 more source

Association of pharmacotherapy with all-cause mortality among patients with irritable bowel syndrome. [PDF]

Commun Med (Lond)
Mehravar S, Yeo YH, Pimentel M, Naji P, Ng WH, Burger N, Takakura W, Rezaie A.   +7 more
europepmc   +1 more source

5‐Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou, Menghua Li, Qi Dai, Xiwang Liu, Cheng Li, Huifeng Jiao, Haili Pan, Renshi Xu   +7 more
wiley   +1 more source