Results 141 to 150 of about 708,936 (290)

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Dually Acting Ligands Targeting Serotonin Receptors: Implications in CNS Disorders. [PDF]

J Med Chem
Trybała W, Grychowska K, Malikowska-Racia N, Nikiforuk A, Popik P, Zajdel P.   +5 more
europepmc   +1 more source

Serotonin Receptors as Therapeutic Targets for Autism Spectrum Disorder Treatment. [PDF]

Int J Mol Sci, 2022
Lee A, Choo H, Jeon B.
europepmc   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain. [PDF]

J Comp Neurol
Galindo KL, Nazir ZA, Silveira MA.
europepmc   +1 more source

Direct Conversion of Aryl Iodides Into Benzylamines by Aminomethylation: Reaction Scope, Mechanistic Studies, and Applications

European Journal of Organic Chemistry, EarlyView.
This study presents an efficient aminomethylation of aryl iodides with formamides for the synthesis of benzylamines using a reusable palladium catalyst at a loading of 65 mol ppm. The substrate scope is systematically evaluated, and mechanistic investigations provide insight into the reaction pathway and the origin of the observed catalytic efficiency.
Abhijit Sen, Atsuya Muranaka, Yu Hatakenaka, Aya Ohno, Yoichi M. A. Yamada   +4 more
wiley   +1 more source

The Antidepressant Vortioxetine Potently Inhibits Cell Growth in Cultured Human Glioblastoma Cells Expressing 5-HT_1B Serotonin Receptors. [PDF]

Cells
Russo V, Russo M, Oliva MA, Alborghetti M, Castaldi S, Di Menna L, Battaglia G, Nicoletti F, Caridi M, Arcella A.   +9 more
europepmc   +1 more source

Ergotamine Stimulates Human 5-HT₄-Serotonin Receptors and Human H₂-Histamine Receptors in the Heart. [PDF]

Int J Mol Sci, 2023
Jacob H, Braekow P, Schwarz R, Höhm C, Kirchhefer U, Hofmann B, Neumann J, Gergs U.   +7 more
europepmc   +1 more source

Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report

Epileptic Disorders, EarlyView.
Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori, Hiroshi Terashima, Yu kakimoto, Mitsuhiro Kato, Shumpei Uchino   +4 more
wiley   +1 more source

Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors. [PDF]

Autism Res
Tarchi L, Doose A, Hennig J, Bernardoni F, King JA, Pisano T, Pisano T, Castellini G, Ricca V, Kamp-Becker I, Ehrlich S.   +10 more
europepmc   +1 more source