Results 81 to 90 of about 198,301 (307)

Dopamine receptors gene expression in male rat hippocampus after administration of MDMA (Ecstasy) [La Expresión Génica de Receptores de Dopamina en el Hipocampo de Ratas Macho Después de la Administración de MDMA (Éxtasis)] [PDF]

, 2015
Ecstasy is one of the most popular amusing drugs among young people. Documents indicate some effects of Ecstasy on hippocampus and close relations between dopaminergic functions with reward learning. Therefore, the aim of this study was evaluation of the
Kamran, H., Majid, S., Mehrdad, J., Simin, M.   +3 more
core  

Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response [PDF]

, 2011
Background: Selective serotonin reuptake inhibitors take several weeks to achieve their full antidepressant effects. Post-synaptic 5-HT_2A receptor activation is thought to be involved in this delayed therapeutic effect ...
A. F. Schatzberg, A. G. Wade, A. McConnachie, Blier, Buntinx, C. B. Nemeroff, Celada, Demyttenaere, E. Buntinx, G. M. Crawford, Gillespie, Guy, L. Haazen, Landen, T. Schlaepfer   +14 more
core   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

Hallucinogens: mechanisms and medical complications [PDF]

, 2013
Thesis (M.A.)--Boston UniversityHallucinogens are drugs that alter consciousness by distorting primarily auditory and visual perception but they can affect any sensory system. Hallucinogens also affect judgment, orientation, memory, or emotion.
Chan, Ryan Harry Alexander
core   +1 more source

Unbalance between Excitation and Inhibition in Phenylketonuria, a Genetic Metabolic Disease Associated with Autism [PDF]

, 2017
Phenylketonuria (PKU) is the most common genetic metabolic disease with a well-documented association with autism spectrum disorders. It is characterized by the deficiency of the phenylalanine hydroxylase activity, causing plasmatic hyperphenylalaninemia
Andolina, Diego, Colamartino, Marco, DE ANGELIS, Federica, DE JACO, Antonella, Favaloro, FLORES LIETTA, Fiori, Elena, Mango, Dalila, Nistico', ROBERT GIOVANNI, Pascucci, Tiziana   +8 more
core   +2 more sources

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

Review of Metabolism, Transport and Role of Serotonin in the Body and the Relation between Serotonin and Diseases

Journal of Fasa University of Medical Sciences, 2013
Serotonin (5-hydroxytriptamine), one of the most important neurotransmitters, is synthesized from amino acid L-tryptophan in some neurons located in the central nervous system and intestine enterochromaffin cells .
Fatemeh Sholehvar, Mohammad Ali Takhshid, Maryam Rafiei   +2 more
doaj  

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

MECHANISM OF INHIBITORY AND STIMULATORY EFFECTS OF SEROTONIN ON DUODENAL CONTRACTIONS

Фундаментальная и клиническая медицина, 2018
Aim. To investigate the effects of serotonin on duodenal motor activity. Materials and Methods. Experiments were performed on Wistar rats (n=83) which received nembutal anesthesia.
VIKTOR M. Smirnov, DMITRIY S. Sveshnikov, ANDREY V. Kuchuk, TATIANA E. Kuznetsova, ELENA D. Ignatova, LARISA V. Trubetskaya   +5 more
doaj  

Imipramine Increases Norepinephrine and Serotonin in the Salivary Glands of Rats

Biology
Xerostomia induced by antidepressants such as imipramine has long been thought to be due to their anticholinergic effects. However, even antidepressants with low anticholinergic effects may have a high incidence of xerostomia.
Kosuke Shirose, Masanobu Yoshikawa, Takugi Kan, Masaaki Miura, Mariko Watanabe, Mitsumasa Matsuda, Hiroyuki Kobayashi, Mitsuru Kawaguchi, Kenji Ito, Takeshi Suzuki   +9 more
doaj   +1 more source