Results 41 to 50 of about 99 (86)
Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach
Medicinal Research Reviews, Volume 44, Issue 6, Page 2545-2599, November 2024.Abstract Opioid receptors belonging to the class A G‐protein coupled receptors (GPCRs) are the targets of choice in the treatment of acute and chronic pain. However, their on‐target side effects such as respiratory depression, tolerance and addiction have led to the advent of the ‘opioid crisis’.
Marie Emilie Hovah, Ulrike Holzgrabe
wiley +1 more source
Transcriptional evidence for the role of chronic venlafaxine treatment in neurotrophic signaling and neuroplasticity including also Glutamatergic [corrected] - and insulin-mediated neuronal processes. [PDF]
PLoS ONE, 2014 Venlafaxine (VLX), a serotonine-noradrenaline reuptake inhibitor, is one of the most commonly used antidepressant drugs in clinical practice for the treatment of major depressive disorder (MDD).
Viola Tamási +7 more
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The role of serotonin in depression—A historical roundup and future directions
Journal of Neurochemistry, Volume 168, Issue 9, Page 1751-1779, September 2024.Although depression has been studied for many decades, the exact mechanisms that lead to depression are still unknown, and available treatments only help a fraction of patients. In the 1960s, the serotonin hypothesis was published, suggesting that serotonin is the key player in depression. However, this hypothesis is being increasingly doubted. In this
Svenja Bremshey +3 more
wiley +1 more source
Does vitamin D supplementation impact serotonin levels? A systematic review and meta‐analysis
Health Science Reports, Volume 7, Issue 8, August 2024.Abstract Background and Aims Vitamin D deficiency impacts a significant proportion of the world's population, and this deficiency has been linked to various conditions characterized by imbalanced serotonin regulation. The objective of this systematic review and meta‐analysis was to evaluate the effect of vitamin D supplementation on serum serotonin ...
Malek Alimohammadi‐Kamalabadi +11 more
wiley +1 more source
Obesity Reviews, Volume 25, Issue 8, August 2024.Summary Objectives To evaluate the impact of bariatric surgery on the pharmacokinetic (PK) parameters of orally administered medications and supplements. Methods Systematic searches of bibliographic databases were conducted to identify studies. Pooled effect estimates from different surgical procedures were calculated using a random‐effects model ...
Fannie Lajeunesse‐Trempe +16 more
wiley +1 more source
Genome-wide association studies in suicidology — analysis of main results
Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019 Studies of suicide genetics can be divided into 3 periods: 1) period of classical methods of behavioral genetics; 2) candidate genes association studies, and 3) genome-wide association studies.
V. A. Rozanov +4 more
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Adaptive Reaktion bei der Lösung von flexiblen Molekülen: Oligohydrate von 4‐Hydroxy‐2‐butanon
Angewandte Chemie, Volume 136, Issue 29, July 15, 2024.Die schrittweise Hydratation eines flexiblen organischen Moleküls zeigt, wie Wassersolvatisierungsgerüste, im Allgemeinen über verschiedene Strukturwege, die Substratstruktur verformen. In diesem Experiment beobachteten wir mithilfe breitbandiger Mikrowellenspektroskopie die Solvatisierung von 4‐Hydroxy‐2‐butanon mit bis zu fünf Wassermolekülen.
Meng Li +4 more
wiley +1 more source
Sous-nutrition, reproduction et système nerveux central chez les mammifères : rôle de la leptine
INRAE Productions Animales, 1999 La relation entre la quantité de réserves adipeuses et la reproduction est connue depuis longtemps, mais le moyen par lequel les animaux sont capables d’estimer leur propre contenu en lipides corporels n’est connu que depuis peu. La leptine, une hormone
P. CHEMINEAU +4 more
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Psychophysiology, Volume 61, Issue 7, July 2024.Abstract During language comprehension, anomalies and ambiguities in the input typically elicit the P600 event‐related potential component. Although traditionally interpreted as a specific signal of combinatorial operations in sentence processing, the component has alternatively been proposed to be a variant of the oddball‐sensitive, domain‐general P3 ...
Friederike Contier +3 more
wiley +1 more source
THE EFFICACY AND SAFETY OF VENLAFAXINE İN TREATMENT OF MAJOR DEPRESSION
Psychiatry and Clinical Psychopharmacology, 2021 Venlafaxine, a novel antidepressant drug for Turkish population , there are both norepinephrine and serotonin reuptake inhibitory effects. An open study was performed to evaluate the antidepressant efficacy and safety of venlafaxine. Fourthy male and 60
Servet Ebrinç +6 more
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