Results 101 to 110 of about 219,974 (370)
Advanced Science, EarlyView.This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du +13 more
wiley +1 more source
Variability in Characterizing Escherichia coli from Cattle Feces: A Cautionary Tale
Microorganisms, 2018 Shiga toxin-producing Escherichia coli (STEC) are diverse bacteria, with seven serogroups (O26, O45, O103, O111, O121, O145, O157; “Top 7”) of interest due to their predominance in human disease.
Kim Stanford +5 more
doaj +1 more source
Zhongguo shipin weisheng zazhi, 2020 Objective To study the serotype distribution and drug resistance of Salmonella isolates from diarrhea cases in Zhongshan City from 2016 to 2017. Methods Serotype of 540 strains of Salmonella spp.
Zhanhong YUAN +5 more
doaj +1 more source
Rapid prediction of crucial hotspot interactions for icosahedral viral capsid self-assembly by energy landscape atlasing validated by mutagenesis [PDF]
, 2020 Icosahedral viruses have their infectious genome encapsulated by a shell assembled by a multiscale process, starting from an integer multiple of 60 viral capsid or coat protein (VP) monomers. We predict and validate inter-atomic hotspot interactions between VP monomers that are important for the assembly of 3 icosahedral viral capsids: Adeno ...
arxiv +1 more source
PLoS Medicine, 2013 In a pooled analysis of data collected from invasive pneumococcal disease surveillance databases, Daniel Feikin and colleagues examine serotype replacement after the introduction of 7-valent pneumococcal conjugate vaccine (PCV7) into national ...
D. Feikin +9 more
semanticscholar +1 more source
Fourth Human Parechovirus Serotype [PDF]
Emerging Infectious Diseases, 2006 We identified a novel human parechovirus (HPeV) type (K251176-02) from a neonate with fever. Analysis of the complete genome showed K251176-02 to be a new HPeV genotype. Since K251176-02 could not be neutralized with antibodies against known HPeV serotypes 1-3, it should be classified as a fourth HPeV serotype.
K.S.M. Benschop +10 more
openaire +3 more sources
SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease
Advanced Science, EarlyView.SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi +11 more
wiley +1 more source
CRISPR applications for Duchenne muscular dystrophy: From animal models to potential therapies
WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023 CRISPR‐Cas9 gene‐editing technology enables the rapid generation of animal models for Duchenne muscular dystrophy research and has potential to be developed as CRISPR therapy for the long lasting genetic correction of causal mutations. Abstract CRISPR gene‐editing technology creates precise and permanent modifications to DNA.
Yu C. J. Chey +4 more
wiley +1 more source
Viruses, 2019 There are four distinct antigenic serotypes of dengue viruses (DENV-1-4). Sequential infections with different serotypes lead to cross-reactive but also serotype-specific neutralizing antibody responses.
Heidi Auerswald +9 more
doaj +1 more source
Hygiene, 2023 Listeria monocytogenes is an ubiquitously occurring foodborne bacterial pathogen known to contaminate foods during the production processes. To assess the presence and persistence of L. monocytogenes in Danish ready-to-eat (RTE) food production companies
Nao Takeuchi-Storm +3 more
doaj +1 more source