Results 101 to 110 of about 239,401 (300)

Development of ListeriaBase and comparative analysis of Listeria monocytogenes [PDF]

, 2015
Background: Listeria consists of both pathogenic and non-pathogenic species. Reports of similarities between the genomic content between some pathogenic and non-pathogenic species necessitates the investigation of these species at the genomic level to ...
Ang, Mia Yang, Choo, Siew Woh, Dutta, Avirup, Heydari, Hamed, Mutha, Naresh VR, Siow, Cheuk Chuen, Tan, Mui Fern, Tan, Shi Yang, Wee, Wei Yee, Wong, Guat Jah   +9 more
core   +3 more sources

The Dengue ED3 Dot Assay, a Novel Serological Test for the Detection of Denguevirus Type-Specific Antibodies and Its Application in a Retrospective Seroprevalence Study

Viruses, 2019
There are four distinct antigenic serotypes of dengue viruses (DENV-1-4). Sequential infections with different serotypes lead to cross-reactive but also serotype-specific neutralizing antibody responses.
Heidi Auerswald, Leonard Klepsch, Sebastian Schreiber, Janne Hülsemann, Kati Franzke, Simone Kann, Bunthin Y, Veasna Duong, Philippe Buchy, Michael Schreiber   +9 more
doaj   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

The occurrence and characterization of Campylobacter jejuni and C. coli in organic pigs and their outdoor environment [PDF]

, 2006
The occurrence and species distribution of thermophilic Campylobacter was investigated in organic outdoor pigs. An increased exposure of outdoor pigs to C. jejuni from the environment may cause a shift from a normal dominance of C. coli to more C. jejuni,
A. Dalsgaard, A.N. Jensen, Alter, Boes, Broman, Brown, D.L. Baggesen, E.M. Nielsen, Ekdahl, Guevremont, Hald, Harvey, Harvey, Jensen, Jensen, Jensen, Kapperud, Kramer, Madden, Manser, Mikkelsen, Moore, Munroe, Nielsen, Penner, Petersen, Ribot, Rosef, Siemer, Totten, Waldenstrom, Weijtens, Weijtens, Weijtens, Young   +34 more
core   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

In vitro screening of probiotic lactic acid bacteria and prebiotic glucooligosaccharides to select effective synbiotics [PDF]

, 2010
Probiotics and prebiotics have been demonstrated to positively modulate the intestinal microflora and could promote host health. Although some studies have been performed on combinations of probiotics and prebiotics, constituting synbiotics, results on ...
Courtin, Céline, Durand, Henri, Grimoud, Julien, Monsan, Pierre, Ouarné, Françoise, Roques, Christine, Theodorou, Vassilia   +6 more
core   +2 more sources

Higher Virulence Renders K2 Klebsiella pneumoniae a Stable Share Among Those from Pyogenic Liver Abscess

Infection and Drug Resistance
Min Dong,1,* Xiumin Ma,2,* Donglian Wang,3,* Xiaobo Ma,4 Jin Zhang,5 Lianhua Yu,5 Qing Yang,6 Dakang Hu,5,7 Dengyan Qiao8 1Department of Pulmonary Diseases (Department of Respiratory and Critical Care Medicine), Gansu Provincial Hospital of ...
Dong M, Ma X, Wang D, Ma X, Zhang J, Yu L, Yang Q, Hu D, Qiao D   +8 more
doaj  

Development of cell lines with increased susceptibility to diverse adeno-associated viral vectors to enable in vitro potency assays

Molecular Therapy: Methods & Clinical Development
Vectors based on adeno-associated viruses (AAVs) are promising therapeutic modalities used in gene therapy. Robust cell-based assays that demonstrate and quantify the potency of AAV vectors in expressing their transgene are needed for clinical ...
James Zengel, Emma S. Esterman, Anitha Ponnuswami, Nicholas R. Wall, Jan E. Carette   +4 more
doaj   +1 more source

Variation in the nuclear effects of infection by different human rhinovirus serotypes.

Frontiers in Microbiology, 2015
Human rhinovirus (HRV) is a positive sense RNA virus, which, despite replicating in the cytoplasm, has a significant impact on nuclear transport and nuclear localisation of host proteins.
Erin Joanne Walker, Lora M Jensen, Sarah N Croft, Reena eGhildyal   +3 more
doaj   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source