Results 111 to 120 of about 206,874 (310)
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao+13 more
wiley +1 more source
Antibiotic Susceptibilities and Serotyping of Clinical Streptococcus Agalactiae Isolates
Objective: Streptococcus agalactiae (Group B streptococci, GBS) are frequently responsible for sepsis and meningitis seen in the early weeks of life. GBS may cause perinatal infection and premature birth in pregnant women.
Altay Atalay+2 more
doaj
Haemophilus influenzae Serotype a Invasive Disease, Alaska, USA, 1983–2011
Before introduction of Haemophilus influenzae type b (Hib) vaccines, rates of Hib disease in Alaska’s indigenous people were among the highest in the world. Vaccination reduced rates dramatically; however, invasive H.
Michael G. Bruce+9 more
doaj +1 more source
Estimating the Attack Ratio of Dengue Epidemics under Time-varying Force of Infection using Aggregated Notification Data [PDF]
Quantifying the attack ratio of disease is key to epidemiological inference and Public Health planning. For multi-serotype pathogens, however, different levels of serotype-specific immunity make it difficult to assess the population at risk. In this paper we propose a Bayesian method for estimation of the attack ratio of an epidemic and the initial ...
arxiv
Additional Rhinovirus Serotypes
SummaryFifty-two rhinovirus strains were isolated from 672 cases of acute respiratory illness in children and adults and 4 strains were recovered from well controls. Respiratory disease cases among adults which yielded a rhinovirus were nearly all upper respiratory illness (common cold) whereas the cases among children often showed lower respiratory ...
Vincent V. Hamparian+2 more
openaire +3 more sources
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong+15 more
wiley +1 more source
Fourth Human Parechovirus Serotype [PDF]
We identified a novel human parechovirus (HPeV) type (K251176-02) from a neonate with fever. Analysis of the complete genome showed K251176-02 to be a new HPeV genotype. Since K251176-02 could not be neutralized with antibodies against known HPeV serotypes 1-3, it should be classified as a fourth HPeV serotype.
Marcel Beld+10 more
openaire +3 more sources
Effect of the enrichment medium on the detection and diversity of Salmonella from porcine duodenal content [PDF]
This study assesses the effect of the enrichment medium used on the isolation of Salmonella from the duodenal content of naturally infected slaughter pigs.
De Busser, Emily Valerie+4 more
core +2 more sources
Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu+9 more
wiley +1 more source
Aim. Study prevalence of adenovirus species and serotypes that had caused acute respiratory viral infection (ARVI) in Moscow in 2004 - 2014. Materials and methods.
S. B Yatsyshina+7 more
doaj