Results 111 to 120 of about 349,425 (383)

Selective and Genetic Constraints on Pneumococcal Serotype Switching

PLoS Genetics, 2015
Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into "serogroups" based on cross-reactivity with certain antibodies.
N. Croucher, L. Kagedan, C. Thompson, J. Parkhill, S. Bentley, J. Finkelstein, M. Lipsitch, W. Hanage   +7 more
semanticscholar   +1 more source

Additional Rhinovirus Serotypes

Experimental Biology and Medicine, 1964
SummaryFifty-two rhinovirus strains were isolated from 672 cases of acute respiratory illness in children and adults and 4 strains were recovered from well controls. Respiratory disease cases among adults which yielded a rhinovirus were nearly all upper respiratory illness (common cold) whereas the cases among children often showed lower respiratory ...
Vincent V. Hamparian, Maurice R. Hilleman, M. B. Leagus   +2 more
openaire   +3 more sources

Construction and Characterization of Adenovirus Serotype 5 Packaged by Serotype 3 Hexon [PDF]

Journal of Virology, 2002
ABSTRACT Adenovirus serotype 5 (Ad5) has great potential for gene therapy applications. A major limitation, however, is the host immune response against Ad5 infection that often prevents the readministration of Ad5 vectors. In this regard, the most abundant capsid protein, hexon, has been implicated as the major target for neutralizing ...
Igor Dmitriev, Toshiro Seki, Minghui Wang, Elena Kashentseva, David T. Curiel, Hongju Wu   +5 more
openaire   +2 more sources

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

Advanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao, Yi Wu, Haiyang Wang, Chenchun Zhang, Ying Zhu, Yan Jiang, Changyou Jiang, Qiumin Le, Xing Liu, Lan Ma, Feifei Wang   +10 more
wiley   +1 more source

Invasive Haemophilus influenzae Disease in Adults ≥65 Years, United States, 2011. [PDF]

, 2014
BackgroundSince the introduction of the Haemophilus influenzae serotype b vaccine, H influenzae epidemiology has shifted. In the United States, the largest burden of disease is now in adults aged ≥65 years.
Bennett, Nancy, Blain, Amy, Briere, Elizabeth, Clark, Thomas, Cohn, Amanda, Farley, Monica M, Harrison, Lee H, Lexau, Catherine, MacNeil, Jessica, Miller, Lisa, Nichols, Megin, Petit, Susan, Reingold, Arthur, Schaffner, William, Thomas, Ann, Wang, Xin   +15 more
core   +1 more source

Complete Coding Genome Sequence of Putative Novel Bluetongue Virus Serotype 27

Genome Announcements, 2015
We announce the complete coding genome sequence of a novel bluetongue virus (BTV) serotype (BTV-n = putative BTV-27) detected in goats in Corsica, France, in 2014.
Maria Jenckel, E. Bréard, C. Schulz, C. Sailleau, C. Viarouge, B. Hoffmann, D. Höper, M. Beer, S. Zientara   +8 more
semanticscholar   +1 more source

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

Advanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang, Donglan Tang, Chenxi Yang, Chao Lin, Yingyue Yuan, Meiying He, Yiying Chen, Zhuo Mao, Ying Ying, Xiaosong Ma, Xiangchen Kong   +10 more
wiley   +1 more source

Serotype-Specific Changes in Invasive Pneumococcal Disease after Pneumococcal Conjugate Vaccine Introduction: A Pooled Analysis of Multiple Surveillance Sites

PLoS Medicine, 2013
In a pooled analysis of data collected from invasive pneumococcal disease surveillance databases, Daniel Feikin and colleagues examine serotype replacement after the introduction of 7-valent pneumococcal conjugate vaccine (PCV7) into national ...
D. Feikin, E. Kagucia, J. Loo, R. Link-Gelles, M. Puhan, T. Cherian, O. Levine, C. Whitney, K. O'Brien, M. Moore   +9 more
semanticscholar   +1 more source

Fourth Human Parechovirus Serotype [PDF]

Emerging Infectious Diseases, 2006
We identified a novel human parechovirus (HPeV) type (K251176-02) from a neonate with fever. Analysis of the complete genome showed K251176-02 to be a new HPeV genotype. Since K251176-02 could not be neutralized with antibodies against known HPeV serotypes 1-3, it should be classified as a fourth HPeV serotype.
Marcel Beld, Manon E Luken, Katja C. Wolthers, Janke Schinkel, Hetty van Eijk, Christina M. J. E. Vandenbroucke-Grauls, Peter J M van den Broek, Matthias F. C. Beersma, Negassi Menelik, Kimberley S. M. Benschop, Hans L. Zaaijer   +10 more
openaire   +3 more sources

Drug Delivery Technologies for the Treatment of Age‐Related Macular Degeneration

Advanced Science, EarlyView.
There are multiple therapeutic agents available for the treatment of both dry age‐related macular degeneration (AMD) and wet AMD. It is essential to continue innovation by introducing new drug delivery technologies that can incorporate those along with patient compliance and the accessibility of the technology into the early stages of research and ...
J Jesus Rodriguez‐Cruz, Jessica Cutrufello, Michael Lam, Shreya Nallaparaju, Nicholas A. Peppas   +4 more
wiley   +1 more source