Results 131 to 140 of about 349,425 (383)

Serotype-Specific Acquisition and Loss of Group B Streptococcus Recto-Vaginal Colonization in Late Pregnancy

PLoS ONE, 2014
Background Maternal recto-vaginal colonization with Group B Streptococcus (GBS) and consequent vertical transmission to the newborn predisposes neonates to early-onset invasive GBS disease.
G. Kwatra, P. Adrian, T. Shiri, E. Buchmann, C. Cutland, S. Madhi   +5 more
semanticscholar   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007

Emerging Infectious Diseases, 2009
Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981 ...
Gelagay Ayelet, Mana Mahapatra, Esayas Gelaye, Berhe G. Egziabher, Tesfaye Rufeal, Mesfin Sahle, Nigel P. Ferris, Jemma Wadsworth, Geoffrey H. Hutchings, Nick J. Knowles   +9 more
doaj   +1 more source

Systematic Evaluation of Serotypes Causing Invasive Pneumococcal Disease among Children Under Five: The Pneumococcal Global Serotype Project

PLoS Medicine, 2010
Hope Johnson and colleagues calculate the global and regional burden of serotype-specific pneumococcal disease in children under the age of five.
H. Johnson, Maria Deloria-Knoll, O. Levine, S. Stoszek, Laura Freimanis Hance, R. Reithinger, L. Muenz, K. O'Brien   +7 more
semanticscholar   +1 more source

Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis

Advanced Science, EarlyView.
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang, Ri Tang, Yang Zhou, Jinquan Zhang, Shuya Mei, Yawen Peng, Xi Huang, Shunpeng Xing, Yuan Gao, Qiaoyi Xu, Zhengyu He   +10 more
wiley   +1 more source

Filamentous Phage Associated with Recent Pandemic Strains of Vibrio parahaemolyticus

Emerging Infectious Diseases, 2001
A group of pandemic strains of Vibrio parahaemolyticus has recently appeared in Asia and North America. We demonstrate that a filamentous phage is specifically associated with the pandemic V. parahaemolyticus strains.
Tetsuya Iida, Akiko Hattori, Kenichi Tagomori, Hatsumi Nasu, Rochman Naim, Takeshi Honda   +5 more
doaj   +1 more source

Transplacental transmission of field and rescued strains of BTV-2 and BTV-8 in experimentally infected sheep [PDF]

, 2013
Transplacental transmission of bluetongue virus has been shown previously for the North European strain of serotype 8 (BTV-8) and for tissue culture or chicken egg-adapted vaccine strains but not for field strains of other serotypes.
Bellacicco, A., Belsham, G.J., Bøtner, A., Caporale, M., Lorusso, A., Palmarini, M., Rasmussen, L., Rasmussen, T., Savini, G.   +8 more
core   +3 more sources

Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain

PLoS ONE, 2013
Adeno-associated virus (AAV) mediated gene expression is a powerful tool for gene therapy and preclinical studies. A comprehensive analysis of CNS cell type tropism, expression levels and biodistribution of different capsid serotypes has not yet been ...
Paramita Chakrabarty, Awilda M. Rosario, P. Cruz, Zoe B. Siemienski, C. Ceballos‐Diaz, Keith W. Crosby, K. Jansen, D. Borchelt, Ji-yoen Kim, J. Jankowsky, T. Golde, Yona Levites   +11 more
semanticscholar   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source