Results 141 to 150 of about 219,974 (370)
Veterinary Sciences, 2020 Highly pathogenic avian influenza H5 viruses have pandemic potential, cause significant economic losses and are of veterinary and public health concerns.
Mohammad M. Hassan +6 more
doaj +1 more source
Virus Antibody Dynamics in Primary and Secondary Dengue Infections [PDF]
arXiv, 2012 Dengue viral infections show unique infection patterns arising from its four serot- ypes, (DENV-1,2,3,4). Its effects range from simple fever in primary infections to potentially fatal secondary infections. We analytically and numerically analyse virus dynamics and humoral response in a host during primary and secondary dengue infection for long ...
arxiv
PeerJ, 2013 We performed culture-based and PCR-based tests for pneumococcal identification and serotyping from carriage specimens collected in rural and urban Kenya.
M. G. Carvalho +13 more
semanticscholar +1 more source
A synthetic platform for developing recombinant adeno‐associated virus type 8 producer cell lines
Biotechnology Progress, EarlyView.Abstract Recombinant adeno‐associated virus (rAAV) is one of the most widely used viral vectors for gene therapy. It is used in very high doses for the treatment of many diseases, making large‐scale production for clinical applications challenging. We have established a synthetic biology‐based platform to construct stable production cell lines, which ...
Yu‐Chieh Lin +5 more
wiley +1 more source
Mathematical Modelling to Investigate a Wolbachia Intervention to Reduce Dengue Transmission [PDF]
arXiv, 2017 The introduction of Wolbachia-carrying mosquitoes into the population has recently been proposed as an alternative strategy against dengue. Although laboratory experiments have shown that the Wolbachia bacterium can reduce the levels of dengue virus in mosquitoes, it is also important to assess the performance of Wolbachia in reducing the incidence of ...
arxiv
Journal of Infectious Diseases, 2003 By use of multilocus sequence typing, Streptococcus pneumoniae isolates causing invasive disease (n=150) were compared with those from nasopharyngeal carriage (n=351) among children in Oxford.
A. B. Brueggemann +5 more
semanticscholar +1 more source
Chemistry – A European Journal, EarlyView.Staphylococcus aureus serotype 1 is a highly virulent pathogen and the capsular polysaccharide (CP1) has been shown to play an important role in virulence and be a target for opsonic antibodies. We here describe the synthesis of a set of CP1 oligosaccharides, varying in length and with different taurination patterns. Abstract Staphylococcus aureus is a
Kitt Emilie Østerlid +4 more
wiley +1 more source
Mapping of the Influenza-A Hemagglutinin Serotypes Evolution by the ISSCOR Method [PDF]
arXiv, 2013 Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile ...
arxiv
Dynamics-based peptide-MHC binding optimization by a convolutional variational autoencoder: a use-case model for CASTELO [PDF]
arXiv, 2020 An unsolved challenge in the development of antigen specific immunotherapies is determining the optimal antigens to target. Comprehension of antigen-MHC binding is paramount towards achieving this goal. Here, we present CASTELO, a combined machine learning-molecular dynamics (ML-MD) approach to design novel antigens of increased MHC binding affinity ...
arxiv
Journal of Infectious Diseases, 2005 The development of rotavirus vaccines that are based on heterotypic or serotype-specific immunity has prompted many countries to establish programs to assess the disease burden associated with rotavirus infection and the distribution of rotavirus strains.
J. Gentsch +14 more
semanticscholar +1 more source