Results 71 to 80 of about 268,563 (331)

Age-dependent acquisition of IgG antibodies to Shigella serotypes—a retrospective analysis of seroprevalence in Kenyan children with implications for infant vaccination

Frontiers in Immunology
BackgroundShigellosis mainly affects children under 5 years of age living in low- and middle-income countries, who are the target population for vaccination.
Melissa C. Kapulu, Melissa C. Kapulu, Esther Muthumbi, Esther Muthumbi, Edward Otieno, Omar Rossi, Pietro Ferruzzi, Francesca Necchi, Alessandra Acquaviva, Laura B. Martin, Benedict Orindi, Kennedy Mwai, Kennedy Mwai, Hillary Kibet, Alfred Mwanzu, Godfrey M. Bigogo, Jennifer R. Verani, Cecilia Mbae, Christopher Nyundo, Charles N. Agoti, Usman Nasir Nakakana, Valentino Conti, Philip Bejon, Philip Bejon, Samuel Kariuki, J. Anthony G. Scott, J. Anthony G. Scott, Francesca Micoli, Audino Podda   +28 more
doaj   +1 more source

The dynamic change of serotype distribution and antimicrobial resistance of pneumococcal isolates since PCV13 administration and COVID-19 control in Urumqi, China

Frontiers in Cellular and Infection Microbiology, 2023
ObjectiveThis study aims to analyze the serotype distribution and drug resistance of Streptococcus pneumoniae isolated from children aged 8 days to 7 years in Urumqi, China, between 2014 to 2021, during which PCV13 was introduced in the private sector’s ...
Meng-Yang Guo, Xing-Hai Shi, Wei Gao, Ju-Ling Tian, Lin Yuan, Juan Yang, Dilinuer Wumaier, Jiang Cao, Reziwaguli Abulimiti, Wen-Li Zhang, Kai-Hu Yao   +10 more
doaj   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Genomic Epidemiology of Streptococcus pneumoniae Isolated in a Tertiary Hospital in Beijing, China, from 2018 to 2022

Pathogens, 2023
Streptococcus pneumoniae is one of the most common bacterial pathogens of a wide range of community-acquired infections. It has been more and more recognized that this bacterium could also play a role as a cause of nosocomial infections.
Shuaihua Fan, Ning Duan, Wenjing Chen, Xiuying Zhao, Lijun Wang, Pengcheng Du, Jun Guo   +6 more
doaj   +1 more source

sRNA23, a novel small RNA, regulates to the pathogenesis ofStreptococcus suisserotype 2 [PDF]

, 2021
Quanming Xu, Hong Chen, Wen Sun, Yongyi Zhang, Dewen Zhu, Kul Raj, Ji‐Long Chen, Ye Chen   +7 more
openalex   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: A longitudinal household study [PDF]

, 2005
Background. Natural immunity to Streptococcus pneumoniae is thought to be induced by exposure to S. pneumoniae or cross-reactive antigens. No longitudinal studies of carriage of and immune responses to S.
Andrews, N, Ashton, L, Edmunds, J, Gay, N, George, R, Goldblatt, D, Hussain, M, Kayhty, H, Melegaro, A, Miller, E, Pebody, R, Soininen, A, Virta, C   +12 more
core  

Serotypes of sex pili [PDF]

Epidemiology and Infection, 1970
SUMMARYThere are situations in which direct observation of the attachment of antibody molecules may be the simplest method of detecting antigen-antibody reactions. Applied to the study of the sex pili determined by a number of transmissible bacterial plasmids, the method has distinguished four serotypes in the F-like class and two in the I-like class ...
A M, Lawn, E, Meynell
openaire   +2 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Modern View on the Problem of Choosing a Vaccine against Hepatitis B

Эпидемиология и вакцинопрофилактика, 2017
The problem of the discrepancy between serotypes of the circulating strains of hepatitis B virus and serotype of the HBsAg in the vaccine is discussed. The results of published scientific studies show that hepatitis B vaccines containing HBsAg serotype ...
V. P. Chulanov, T. A. Semenenko, I. V. Karandashova, S. V. Komarova, D. S. Kostyushev, A. P. Suslov, E. V. Volchkova   +6 more
doaj   +1 more source