Results 111 to 120 of about 54,993 (303)

Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice

, 2009
Background: Adeno-associated virus serotype 2 (AAV2) vectors show considerable promise for ocular gene transfer. However, one potential barrier to efficacious long-term therapy is the development of immune responses against the vector or transgene ...
Ali, R.R., Buch, P, Barker, S.E., Robbie, S.J., Natkunarajah, M, Maclaren, Robert, Broderick, CA, Smith, A.J., Natkunarajah, M., Duran, Y, Buch, P., Ali, RR, Maclaren, RE, Balaggan, K.S., Duran, Y., MacLaren, R.E., Bainbridge, J.W. B., Bainbridge, JW, Barker, SE, Broderick, C.A., Robbie, SJ, Balaggan, KS, Smith, AJ   +22 more
core   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

In‐line Raman spectroscopy real‐time glucose prediction method for commercial pneumococcal vaccine drug substance fermentation manufacturing process control

Biotechnology Progress, EarlyView.
Abstract Traditional off‐line analysis methods to quantify residual metabolite concentrations in a drug substance fermentation process consume valuable time, require costly resources, and demand potentially hazardous manual operations when working with pathogenic biological organisms.
Griffin P. Thomas, Brian C. Marks, Barbara B. Alvarado‐Hernandez, Matthew Woodling, James O'Connor, Roberto Ortiz, John Higgins, Jon Shanter   +7 more
wiley   +1 more source

THE ROLE OF PIGS AS PHARYNGEAL CARRIERS OF HUMAN PATHOGENIC YERSINIA ENTEROCOLITICA STRAINS

Italian Journal of Food Safety, 2013
From March 2007 to January 2008, a total of 170 pigs at slaughter were tested for Y. enterocolitica contamination in tonsils tissue. The animals came from 125 different farms located in four regions of Northern Italy. Y.
M. D’Incau, F. Brindani, S. Tagliabue, F. Salmi, C. Bacci, M.E. Floriani, S. Bignami, S. Bonardi, A. Paris   +8 more
doaj   +1 more source

Isolation of an Avianlike Group A Rotavirus from a Calf with Diarrhea [PDF]

, 1992
An atypical group A rotavirus (993/83) was isolated from a 3-day-old German calf with diarrhea. It differed from 35 conventional German bovine rotavirus isolates analyzed previously with respect to subgroup (strain 993/83 was non-subgroup I and non ...
Gerna, Giuseppe, Eichhorn, Werner, Nakagomi, Osamu, Büssow, Harald   +3 more
core  

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Identification of d-Galactan-III As Part of the Lipopolysaccharide of Klebsiella pneumoniae Serotype O1

Frontiers in Microbiology, 2017
Klebsiella pneumoniae is a Gram-negative, ubiquitous bacterium capable of causing severe nosocomial infections in individuals with impaired immune system. Emerging multi-drug resistant strains of this species and particularly carbapenem-resistant strains
Jolanta Lukasiewicz, Katarina Stojkovic, Valéria Szijártó, Marta Kaszowska, Tomasz Niedziela, Katharina Hartl, Gábor Nagy   +6 more
doaj   +1 more source

Structure and genetic basis of Yersinia similis serotype O:9 O-specific polysaccharide

Innate Immunity, 2013
The O-polysaccharide (OPS, O-Ag) cap of LPS is a major virulence factor of Yersinia species and also serves as a receptor for the binding of lytic bacteriophage φR1-37.
Agnieszka, Beczała, Olga G, Ovchinnikova, Neeta, Datta, Laura, Mattinen, Katarzyna, Knapska, Joanna, Radziejewska-Lebrecht, Otto, Holst, Mikael, Skurnik   +7 more
openaire   +2 more sources

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source

Serotype Diversity of Foot And Mouth Disease Virus and Molecular Characterization of Serotype O Strains from 2019 and 2020 Outbreaks in Kenya [PDF]

Benha Veterinary Medical Journal
Foot and mouth disease (FMD) is a viral infection affecting ruminants and leads to great economic losses. Control and prevention have been a challenge despite the availability of vaccines.
Judith Josiah, Anthony Nyamache, Fanos Woldemariyam, Christopher Kariuki, Jan Paeshuyse, Joseph Kamau   +5 more
doaj   +1 more source