Results 101 to 110 of about 115,869 (313)

Distribution of Serotypes Causing Invasive Pneumococcal Disease in Children From High-Income Countries and the Impact of Pediatric Pneumococcal Vaccination

, 2022
BACKGROUND: The introduction and adoption of pneumococcal conjugate vaccines (PCVs) into pediatric national immunization programs (NIPs) has led to large decreases in invasive pneumococcal disease (IPD) incidence caused by vaccine serotypes.
Jodar, Luis, Grant, Lindsay R, Theilacker, Christian, Slack, Mary PE, Vojicic, Jelena, Reinert, Ralf Rene, Dion, Stephane, Gessner, Bradford D   +7 more
core   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, EarlyView.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source

Pneumococcal serotype-specific antibodies persist through early childhood after infant immunization: follow-up from a randomized controlled trial

, 2014
BACKGROUND: In a previous UK multi-center randomized study 278 children received three doses of 7-valent (PCV-7) or 13-valent (PCV-13) pneumococcal conjugate vaccine at 2, 4 and 12 months of age.
Trück, J, Yu, Ly-Mee, Finn, Adam, Ly-Mee Yu (44961), Pollard, Andrew J, Pollard Andrew J., Trück, Johannes; https://orcid.org/, Faust, Saul N, Johannes Trück, Merryn Voysey, Paul T. Heath (533551), Yu Ly-Mee, Voysey, M, Saul N. Faust (415924), Tatangeli, F, Andrew J Pollard, Voysey Merryn, Heath Paul T., Tatangeli, Florencia, Adam Finn (23223), Florencia Tatangeli (533550), Faust, S.N., Snape, MD, Pollard, AJ, Pollard, Andrew, Heath, PT, Adam Finn, Snape, Matthew, Merryn Voysey (255058), Faust Saul N., Andrew J. Pollard (44971), Snape Matthew D., Heath, Paul T, Voysey, Merryn, Yu, LM, Paul T Heath, Finn Adam, Tatangeli Florencia, Matthew D. Snape (533549), Faust, SN, Matthew D Snape, Finn, A, Snape, Matthew D, Florencia Tatangeli, Saul N Faust, Pollard, Andrew J., Ly-Mee Yu, Johannes Trück (533548), Truck, Johannes, Trück Johannes, Heath, Paul   +50 more
core   +1 more source

Systematic Literature Review of the Epidemiological Characteristics of Pneumococcal Disease Caused by the Additional Serotypes Covered by the 20-Valent Pneumococcal Conjugate Vaccine

, 2023
Higher valency pneumococcal conjugate vaccines (PCV15 and PCV20) have been developed to address the disease burden of current non-vaccine serotypes. This review describes the epidemiological characteristics of serotypes beyond PCV13 (serotypes 8, 10A ...
Fletcher, Mark AA, Bradford D. Gessner, Grant, Lindsay RR, Mary P. E. Slack, Mark A. Fletcher, Hanquet, Germaine, Germaine Hanquet, Marc Baay, Kyla Hayford, Baay, Marc, Hayford, Kyla, Gessner, Bradford DD, Lindsay R. Grant, Slack, Mary PE, Meroc, Estelle, Estelle Méroc   +15 more
core   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Antimicrobial susceptibility of the 280 isolates among PCV10 serotypes, PCV13 additional serotypes, serogroups, pool only and non vaccines serotypes (NVT).

, 2016
Antimicrobial susceptibility of the 280 isolates among PCV10 serotypes, PCV13 additional serotypes, serogroups, pool only and non vaccines serotypes (NVT).
Maria Alexandrou (360233), Loukia Panayiotou (3195834), Adamos Hadjipanayis (3195825), Elisavet Efstathiou (3195837), Panayiotis Petrou (3195822), Vasiliki Papaevangelou (3195828), Chrystalla Zachariadou (3195831)   +6 more
core   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Characterization of Streptococcus pneumoniae isolates from India with special reference to their sequence types

Journal of Infection in Developing Countries, 2013
Introduction: Streptococcus pneumoniae is a major cause of mortality and morbidity in young children and the elderly. In the present study we evaluated antimicrobial susceptibilities, serotypes, and sequence types of pneumococcal isolates recovered in ...
Malini Shariff, Jyoti Choudhary, Shazia Zahoor, Monorama Deb   +3 more
doaj   +1 more source

Optimal Serotype Compositions for Pneumococcal Conjugate Vaccination under Serotype Replacement

PLoS Computational Biology, 2014
Pneumococcal conjugate vaccination has proved highly effective in eliminating vaccine-type pneumococcal carriage and disease. However, the potential adverse effects of serotype replacement remain a major concern when implementing routine childhood pneumococcal conjugate vaccination programmes.
Markku Nurhonen, Kari Auranen
openaire   +4 more sources

Genetic and Epidemiological Characterization of Streptococcus pneumoniae disease determinants.

, 2011
The Gram-positive pathogen Streptococcus pneumoniae is a major cause of community acquired pneumonia as well as of upper respiratory tract infections such as acute otitis media and sinusitis, and invasive diseases like meningitis, bacteremia, and ...
Melchiorre, Sara
core