Results 111 to 120 of about 115,869 (313)

In‐line Raman spectroscopy real‐time glucose prediction method for commercial pneumococcal vaccine drug substance fermentation manufacturing process control

Biotechnology Progress, EarlyView.
Abstract Traditional off‐line analysis methods to quantify residual metabolite concentrations in a drug substance fermentation process consume valuable time, require costly resources, and demand potentially hazardous manual operations when working with pathogenic biological organisms.
Griffin P. Thomas, Brian C. Marks, Barbara B. Alvarado‐Hernandez, Matthew Woodling, James O'Connor, Roberto Ortiz, John Higgins, Jon Shanter   +7 more
wiley   +1 more source

Novel Type of Streptococcus pneumoniae Causing Multidrug-Resistant Acute Otitis Media in Children

Emerging Infectious Diseases, 2009
After our recent discovery of a Streptococcus pneumoniae 19A “superbug” (Legacy strain) that is resistant to all Food and Drug Administration–approved antimicrobial drugs for treatment of acute otitis media (AOM) in children, other S. pneumoniae isolates
Qingfu Xu, Michael E. Pichichero, Janet R. Casey, Mingtao Zeng   +3 more
doaj   +1 more source

Fourth Human Parechovirus Serotype

Emerging Infectious Diseases, 2006
We identified a novel human parechovirus (HPeV) type (K251176-02) from a neonate with fever. Analysis of the complete genome showed K251176-02 to be a new HPeV genotype. Since K251176-02 could not be neutralized with antibodies against known HPeV serotypes 1-3, it should be classified as a fourth HPeV serotype.
Benschop, Kimberley S. M., Schinkel, Janke, Luken, Manon E., van den Broek, Peter J. M., Beersma, Matthias F. C., Menelik, Negassi, van Eijk, Hetty W. M., Zaaijer, Hans L., Vandenbroucke-Grauls, Christina M. J. E., Beld, Marcel G. H. M., Wolthers, Katja C.   +10 more
openaire   +3 more sources

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Emerging resistant serotypes of invasive Streptococcus pneumoniae

, 2016
Sittana Elshafie,1,2 Saad J Taj-Aldeen2,3 1Qatar Orthopedic and Sports Medicine Hospital, Aspetar, Doha, Qatar; 2Weill Cornell Medicine-Qatar, 3Department of Laboratory Medicine and Pathology, Microbiology Division, Hamad Medical Corporation, Doha, Qatar
Taj-Aldeen SJ, Elshafie S
core  

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

Epidemiological characteristic of Streptococcus pneumoniae serotypes from patients with invasive pneumococcal disease in the Russian Federation [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. To characterize spectrum of S. pneumoniae serotypes isolated from patients with invasive pneumococcal infection in the Russian Federation. Materials and Methods. The serotype identification of 93 S.
Muravyev A.A., Chagaryan A.N., Ivanchik N.V., Mironov K.O., Gaponova I.I., Kozlov R.S.   +5 more
doaj   +1 more source

Serotype Characterization and Transmission Modelling of Foot-and-Mouth Disease in Dairy Farms, Bishoftu, Ethiopia. [PDF]

Vet Med Sci
FMD outbreaks in dairy farms in Bishoftu were characterized by rapid within‐farm transmission (R0 = 3.7) and predominance of the SAT‐2 serotype. Current trivalent vaccination alone was insufficient for control, highlighting the need for improved vaccine matching and strengthened biosecurity measures . ABSTRACT Background Foot‐and‐mouth disease (FMD) is
Fetene E, Shegu D, Muluneh A, Aliy A, Paeshuyse J, Woldemariyam FT, Negussie H, Leta S.   +7 more
europepmc   +2 more sources

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source