Results 141 to 150 of about 115,869 (313)

Five‐Year Outcomes With Delandistrogene Moxeparvovec in Patients With Duchenne Muscular Dystrophy: A Phase 1/2a Study

Muscle &Nerve, EarlyView.
ABSTRACT Aims We report 5‐year results from a phase 1/2a study of delandistrogene moxeparvovec, a recombinant adeno‐associated virus serotype rh74 vector‐based gene therapy for Duchenne muscular dystrophy (DMD), with post hoc analyses contextualizing functional outcomes. Methods Four ambulatory patients with DMD (≥ 4–< 8 years at enrollment) entered an
Jerry R. Mendell, Zarife Sahenk, Linda P. Lowes, Megan A. Iammarino, Lindsay N. Alfano, Craig M. McDonald, James E. Signorovitch, Jim Jin, Jing Li, Stefanie Mason, Louise R. Rodino‐Klapac   +10 more
wiley   +1 more source

The serotype of Rotavirus.

Uirusu, 1992
Urasawa, Shozo, Taniguchi, Koki, Kobayashi, Nobumichi   +2 more
openaire   +3 more sources

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Development of novel vaccines for the concurrent immunisation against multiple dengue virus serotypes

, 2006
A major obstacle to the development of dengue virus (DENV) vaccines has been the need to immunise concurrently against each of the four DENV serotypes in order to avoid sensitising recipients to developing severe DENV infections.
Liew, Steven Christopher
core  

Distribution and invasiveness of Streptococcus pneumoniae serotypes in Switzerland, a country with low antibiotic selection pressure, from 2001 to 2004

, 2006
To describe the serotype-specific epidemiology of colonizing and invasive Streptococcus pneumoniae isolates, which is important for vaccination strategies, we analyzed a total of 2,388 invasive and 1,540 colonizing S.
Zucs, Phillip, Kronenberg, Andreas, Mühlemann, Kathrin, Droz, Sara   +3 more
core   +1 more source

Botulinum toxin use in patients with neurological disorders: A U.S.‐based claims database analysis

PM&R, EarlyView.
Abstract Background and Objective Real‐world evidence describing long‐term persistency with botulinum toxin (BoNT) therapy is limited. We assessed treatment patterns and persistency with BoNT in clinical practice over 2 years. Design Retrospective, longitudinal, claims database analysis. Setting Medical claims data from the Merative MarketScan database
David M. Simpson, Jonathan Bouchard, Simon Page, Seth Goldfarb, Atul T. Patel   +4 more
wiley   +1 more source

Progress On Sensorineural Hearing Loss: Mechanisms and Therapies

Sensory Neuroscience, EarlyView.
ABSTRACT Hearing loss is the most common disabling disease among humans, which adversely affects human health. Sensorineural hearing loss (SNHL) accounting for approximately 63% of all hearing loss cases. SNHL may be classified into age‐related hearing loss (ARHL), drug‐induced hearing loss (DIHL), noise‐induced hearing loss (NIHL), and sudden ...
Yuan Zhang, Shen Li, Yangfan Zhou, Duopin Li, Junru Ding, Ruifeng Qiao, Yutian Chen, Fanglei Ye, Le Wang, Peipei Li   +9 more
wiley   +1 more source

Antimicrobial resistance of Streptococcus pneumoniae strains isolated from children following immunization with a 13-valent conjugated vaccine

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Monitoring the resistance of Streptococcus pneumoniae to antimicrobials is an important component of epidemiological surveillance of pneumococcal infection, addressing the challenges of improving therapeutic approaches and containing the ...
Irina N. Protasova, Irina V. Feldblium, Natalya V. Bakhareva, Ludmila V. Zinovieva, Elena V. Kulik   +4 more
doaj   +1 more source

Comparative Analysis of Pneumococcal Serotypes for 10 Years (2014–2024) in the Comunidad Valenciana Region, Spain, and How They Are Correlated with PCV13, PCV20, and PCV21

Vaccines
Background/Objectives: This study analyzes the epidemiology of invasive pneumococcal disease (IPD) and the dynamics of Streptococcus pneumoniae (SP) serotypes in the Comunidad Valenciana (CV) region, Spain, over a 10-year period (2014–2024), with ...
Laura Diab-Casares, Nuria Tormo-Palop, Rafael Medina-González, Sonia Cortés-Badenes, Francisco Javier Hernández-Felices, Violeta Artal-Muñoz, José Luis Martín-Rodríguez, Francisco Roig-Sena, José Manuel Marín, María Dolores Gómez-Ruiz, Francisco José Rodríguez-Nortes, Mariana Lamas-Santángelo, Concepción Gimeno-Cardona, Remedio Guna-Serrano   +13 more
doaj   +1 more source

Coexistence of different serotypes of dengue virus

, 2003
We formulate a non-linear system of differential equations that models the dynamics of dengue fever. This disease is produced by any of the four serotypes of dengue arbovirus.
Vargas, C, Esteva, L
core   +1 more source