Results 131 to 140 of about 135,623 (345)
Techno‐Economic Analysis of Membrane‐Based Purification Platforms for AAV Vector Production
Biotechnology and Bioengineering, EarlyView.ABSTRACT Technologies for large‐scale manufacturing of viral vectors for gene therapies, such as tangential flow filtration and membrane chromatography, are under development. In these early stages of process development, techno‐economic analyses are useful for identifying membrane properties yielding the greatest impact on process performance. In this
Juan J. Romero +6 more
wiley +1 more source
MicroorganismsListeria monocytogenes (L. monocytogenes) poses a significant threat to food safety due to its ability to cause severe human illness and its resistance to various antibiotics and environmental conditions.
Mihaela Niculina Duma +4 more
doaj +1 more source
New Salmonella Serotype: Salmonella enteritidis ser. Ordonez [PDF]
, 1969 Sylvia F. Bartes +4 more
openalex +1 more source
Enrichment of Full AAV2 Using Multicolumn Countercurrent Solvent Gradient Purification (MCSGP)
Biotechnology and Bioengineering, EarlyView.The multicolumn countercurrent solvent gradient purification (MCSGP) method was evaluated as a method to enhance the separation of empty and full capsids during AAV2 purification. The results demonstrated an enrichment of full AAV2 particles using MCSGP.
Julia M. Müller +9 more
wiley +1 more source
Drug resistance and molecular typing of Salmonella isolated from foodborne diseases in Ganzhou City
Zhongguo shipin weisheng zazhiObjectiveTo provide scientific basis for rational clinical use and traceability of outbreaks of foodborne Salmonellosis， the drug resistance and molecular typing characteristics of foodborne Salmonella in Ganzhou City was understood， and a database of ...
FANG Huan +7 more
doaj +1 more source
H SEROTYPE DIFFERENTIATION IN TETRAHYMENA [PDF]
, 1963 David L. Nanney +3 more
openalex +1 more source
Iterative hybrid model based optimization of rAAV production
Biotechnology Progress, EarlyView.Abstract Changes in serotype or genetic payload of recombinant adeno associated virus (rAAVs) gene therapies require adapting the transfection conditions of the upstream HEK293 cultivations. This study adopts an iterative model‐based experiment design approach, where increasing data availability is leveraged to evolve models of different complexity ...
Claudio Müller +7 more
wiley +1 more source
Zhongguo shipin weisheng zazhiObjectiveTo provide scientific basis for the prevention and control， early warning， tracing and clinical treatment of diarrheal diseases caused by Salmonella， the serotype distribution， drug resistance and molecular typing characteristics of Salmonella ...
SHEN Yuehua +4 more
doaj +1 more source
Biotechnology Progress, EarlyView.Abstract Recombinant adeno‐associated virus (rAAV) is a widely used delivery vehicle in gene therapy. A scalable production technology is essential for its wide clinical applications. We have taken a synthetic biology approach to generate HEK293‐based cell lines which harbor integrated genetic elements encoding essential AAV and adenoviral helper ...
Han‐Jung Kuo +6 more
wiley +1 more source
Accelerating AAV purification process development using high‐throughput resin tip module
Biotechnology Progress, EarlyView.Abstract Recombinant adeno‐associated viruses (AAVs) with precise genome editing and cell‐virus interaction have become a promising delivery tool for gene therapy. A robust AAV purification process is crucial for ensuring therapeutic efficacy. The challenges of AAV purification process development encompass limited material availability during early ...
Qingxuan Li +3 more
wiley +1 more source