Results 111 to 120 of about 51,591 (309)

Emergence of a multidrug resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13 [PDF]

, 2021
Stephanie W. Lo, Kate C. Mellor, Robert Cohen, Alba Redin Alonso, Sophie Belman, Narender Kumar, Paulina A. Hawkins, Rebecca A. Gladstone, Anne von Gottberg, Balaji Veeraraghavan, KL Ravikumar, Rama Kandasamy, Andrew J. Pollard, Samir K. Saha, Godfrey Bigogo, Martín Antonio, Brenda Kwambana-Adams, Shaper Mirza, Sadia Shakoor, Muhammad Imran Nisar, Jennifer Cornick, Deborah Lehmann, Rebecca Ford, Betuel Sigaúque, Paul Turner, Jennifer C. Moïsi, Stephen Obaro, Ron Dagan, Naima Elmdaghri, Anna Skoczyńska, Hui Wang, Philip E. Carter, Keith P. Klugman, Gail L. Rodgers, Robert F. Breiman, Lesley McGee, Stephen D. Bentley, Carmen Muñoz‐Almagro, Emmanuelle Varon   +38 more
openalex   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

Pneumococcal serotypes in sputum isolates during acute respiratory illness in Edinburgh. [PDF]

, 1987
G A Gould, G B Rhind, Alanna Morgan, Graham Williamson, M A Calder   +4 more
openalex   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Serovar-level identification of bacterial foodborne pathogens from full-length 16S rRNA gene sequencing

mSystems
The resolution of variation within species is critical for interpreting and acting on many microbial measurements. In the key foodborne pathogens Salmonella and Escherichia coli, the primary subspecies classification scheme used is serotyping ...
Dmitry Grinevich, Lyndy Harden, Siddhartha Thakur, Benjamin Callahan   +3 more
doaj   +1 more source

Capture of adeno‐associated viruses from clarified lysate by continuous flow ultracentrifugation: a comparative study of iodixanol and sucrose gradients

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Adeno‐Associated Virus vectors are widely used in gene therapy due to their safety and efficacy. Despite the interest in their therapeutical application, AAV purification remains a significant challenge. Density gradient ultracentrifugation using cesium chloride, sucrose, or iodixanol gradients are common methods for AAV ...
Sabrina Leigheb, Maral Rahimzadeh, Nikolaus Virgolini, Aida Tleuova, Mahbod Mousavian, Astrid Dürauer, Patricia Pereira Aguilar   +6 more
wiley   +1 more source

International circumpolar surveillance: update on the interlaboratory quality control program for Streptococcus pneumoniae, 2009 to 2020

Microbiology Spectrum
The International Circumpolar Surveillance (ICS) program is a population-based surveillance network for invasive bacterial diseases throughout Arctic countries and territories.
Alyssa R. Golden, Averil Griffith, Brenna C. Simons, Alisa Reasonover, Hans-Christian Slotved, Brigitte Lefebvre, Karl G. Kristinsson, Donna Hurteau, Gregory J. Tyrrell, Michael G. Bruce, Irene Martin   +10 more
doaj   +1 more source

Characterisation of a collection of Streptococcus pneumoniae isolates from patients suffering from acute exacerbations of chronic bronchitis: In vitro susceptibility to antibiotics and biofilm formation in relation to antibiotic efflux and serotypes/serogroups

, 2014
N Vandevelde, Paul M. Tulkens, Yvan Diaz Iglesias, Jan Verhaegen, Hector Rodriguez‐Villalobos, Ivan Philippart, Julie Cadrobbi, Nathalie Coppens, An Boel, Kristien Van Vaerenbergh, Hugo Francart, R. Vanhoof, Giuseppe Liistro, Paul Jordens, Jean-Paul d’Odemont, Y. Valcke, Franck Verschuren, Françoise Van Bambeke   +17 more
openalex   +2 more sources