Results 131 to 140 of about 144,200 (356)

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Detection of Streptococcus pneumoniae serotypes causing invasive and non-invasive infections using whole-genome sequencing [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. Seroyping of the Streptococcus pneumoniae strains obtained from patients with invasive and non-invasive forms of pneumococcal infection circulating in Russia using whole-genome sequencing. Materials and Methods. The 144 invasive and 90 non-
Mironov К.O., Gaponova I.I., Korchagin V.I., Mikhailova Yu.V., Shelenkov A.A., Chagaryan A.N., Ivanchik N.V., Platonov A.E., Kozlov R.S., Akimkin V.G.   +9 more
doaj   +1 more source

Production of latex agglutination reagents for pneumococcal serotyping

BMC Research Notes, 2013
BackgroundThe current ‘gold standard’ for serotyping pneumococci is the Quellung test. This technique is laborious and requires a certain level of training to correctly perform.
B. Ortika, Maha Habib, E. Dunne, Barbara D. Porter, C. Satzke   +4 more
semanticscholar   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Preparation, Component Identification, and Antioxidant Activity of Anthocyanins From Punica granatum “Tunisia”

AgriFood: Journal of Agricultural Products for Food, EarlyView.
The preparation for Tunisian pomegranate anthocyanin extract. The molecular mechanisms underlying the antioxidant effects of these compounds were investigated using network pharmacology and molecular docking. Antioxidant activity was evaluated through DPPH, ABTS, and FRAP assays, whereas the effects on oxidative stress and inflammation were examined in
Jing Zhang, Xu‐han Yang, Meng‐qi Zhang, Xu Guo, Ning‐yang Li, Fang‐yu Long, Chao Liu   +6 more
wiley   +1 more source

Isolation, Serotyping, and Antibiogram of Salmonella Isolates from Raw Milk Sold at Retail Vending in Erbil City, Iraq

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies, 2019
Pathogenic strains of Salmonella cause gastroenteritis in humans globally.This study aimed to determine the prevalence and antibiotic susceptibility pattern of Salmonellain raw milk sold in Erbil city, Kurdistanregion, Iraq.
Dhary Alewy ALMASHHADANY, Ardalan Abdulhamed OSMAN   +1 more
doaj   +1 more source

Multiresistant Salmonella enterica serovar 4,[5],12:i:- in Europe: a new pandemic strain? [PDF]

, 2010
A marked increase in the prevalence of S. enterica serovar 4,[5],12:i:- with resistance to ampicillin, streptomycin, sulphonamides and tetracyclines (R-type ASSuT) has been noted in food-borne infections and in pigs/pig meat in several European countries
Granier, A., Guerra, B., Hopkins, K.L., Jakubczak, A., Kirchner, M., Lucarelli, C., Mevius, D.J., Porrero, M.C., Threlfall, J.   +8 more
core   +3 more sources

Genetic characterization of Mycobacterium avium isolates recovered from humans and animals in Australia [PDF]

, 1996
Genetic relationships amongst 115 mainly Australian isolates of Mycobacterium avium were assessed using multilocus enzyme electrophoresis (MEE). The isolates were divided into 58 electrophoretic types (ETs), with a mean genetic diversity of 0·29 ...
Feizabadi, M.M., Robertson, I.D., Cousins, D.V., Dawson, D., Chew, W., Gilbert, G.L., Hampson, D.J.   +6 more
core   +2 more sources

The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva, Karen Herbert, Lakshmi Balaji, Jia Mei He, Tejaswi Kandula, Hugo A. Sampaio, Hooi‐Ling Teoh, Esther Tantsis, Jihee Sohn, Nancy Briggs, Nickson Ning, Matthew C. Kiernan, Didu S. Kariyawasam, Michelle A. Farrar   +13 more
wiley   +1 more source

Optimal Serotype Compositions for Pneumococcal Conjugate Vaccination under Serotype Replacement

PLoS Computational Biology, 2014
Pneumococcal conjugate vaccination has proved highly effective in eliminating vaccine-type pneumococcal carriage and disease. However, the potential adverse effects of serotype replacement remain a major concern when implementing routine childhood pneumococcal conjugate vaccination programmes.
Markku Nurhonen, Kari Auranen
openaire   +4 more sources