Results 151 to 160 of about 51,591 (309)

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

Movement and Survival of Spodoptera litura (Lepidoptera: Noctuidae) Neonate Larvae on Cotton Expressing Bacillus thuringiensis Proteins

Entomologia Experimentalis et Applicata, EarlyView.
Spodoptera litura neonates showed increased movement on Bt‐expressing Bollgard 3 (BG) cotton leaf discs but did not initially avoid it. Survival was higher when larvae could move from BG3 to non‐Bt leaf discs. On whole plants, more larvae dispersed from hatching on BG3 cotton compared to non‐Bt cotton. These findings suggest the larval movement differs
Sharna Holman, Paul Grundy, Helen Spafford, Michael J. Furlong   +3 more
wiley   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

548. Overcoming Anti-AAV Neutralizing Antibodies with Alternate Serotype and Pharmacological Strategies [PDF]

, 2010

openalex   +1 more source

Determination of foot-and-mouth disease serotypes from naturally infected cattle by solid phase competitive ELISA (SPCE) techniques

, 2022
Ayelech Muluneh, Fanos Tadesse Woldemariyam   +1 more
openalex   +1 more source

Human Rhinovirus A16 Infection of Mast Cells Promotes T2 and Non‐T2 Immune Responses That Are Modulated by the Airway Epithelium

Allergy, EarlyView.
Ying Lai, Ryan C. Murphy, Matthew Liu, Maciej W. Czarnecki, Dane Grosvenor, Kimberly A. Dill‐McFarland, Adrian M. Piliponsky, Jason S. Debley, Matthew C. Altman, Teal S. Hallstrand   +9 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Genomic analysis of Salmonella enterica serotype Paratyphi A during an outbreak in Cambodia, 2013–2015

, 2016
Laura Maria Francisca Kuijpers, Simon Le Hello, Nizar Fawal, Laëtitia Fabre, Mathieu Tourdjman, Muriel Dufour, Dara Sar, Chun Kham, Thong Phe, Erika Vlieghe, Christiane Bouchier, Jan Jacobs, François‐Xavier Weill   +12 more
openalex   +1 more source

Treatment With Valoctocogene Roxaparvovec in a Patient With Severe Hemophilia A Led to Sustained Normal FVIII Levels

Haemophilia, EarlyView.
ABSTRACT Introduction Valoctocogene roxaparvovec, an adeno‐associated virus (AAV)‐based gene therapy, enables endogenous factor VIII (FVIII) expression in patients with severe hemophilia A without the need for regular FVIII infusions. Long‐term follow‐up assesses durability, safety, and immune‐related challenges following gene therapy.
Kerstin Herbst, Behnaz Pezeshkpoor, Claudia Klein, Thilo Albert, Philipp Lutz, Christian Strassburg, Ulrich Spengler, Georg Goldmann, Johannes Oldenburg   +8 more
wiley   +1 more source

Rapid Interventions to Limit Outbreak of Invasive Streptococcus pneumoniae in Correctional Facility, North Carolina, USA, 2024. [PDF]

Emerg Infect Dis
Gowler CD, Doran E, Williams ND, Albertson JP, Lautenschlager T, Chochua S, Gierke R, Campbell A, Kobayashi M, Fleischauer A, Wilson E.   +10 more
europepmc   +1 more source