Results 91 to 100 of about 144,200 (356)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Drug resistance and molecular typing of Salmonella isolated from foodborne diseases in Ganzhou City

Zhongguo shipin weisheng zazhi
ObjectiveTo provide scientific basis for rational clinical use and traceability of outbreaks of foodborne Salmonellosis， the drug resistance and molecular typing characteristics of foodborne Salmonella in Ganzhou City was understood， and a database of ...
FANG Huan, WANG Jielian, TANG Manmei, WANG Juexin, SU Junzhi, HU Xiaojun, LIAO Yong, LEI Qiong   +7 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Pathogenic characteristics of Salmonella in infectious diarrhea cases in Huzhou City from 2021 to 2022

Zhongguo shipin weisheng zazhi
ObjectiveTo provide scientific basis for the prevention and control， early warning， tracing and clinical treatment of diarrheal diseases caused by Salmonella， the serotype distribution， drug resistance and molecular typing characteristics of Salmonella ...
SHEN Yuehua, JI Lei, XU Deshun, WU Xiaofang, YAN Wei   +4 more
doaj   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

The speciation and genotyping of Cronobacter isolates from hospitalised patients [PDF]

, 2015
The World Health Organization (WHO) has recognised all Cronobacter species as human pathogens. Among premature neonates and immunocompromised infants, these infections can be life-threatening, with clinical presentations of septicaemia, meningitis and ...
[No authors listed], A Baldwin, A. Alsonosi, AB Bowen, BJ Stoll, C Brady, FC Tenover, H Liu, H. Drahovská, H. Kollárová, International Commission on Microbiological Specifications for Foods (ICMSF), J Acker van, J Caubilla-Barron, J. Petrželová, K Tamura, KG Jarvis, KK Lai, M. Kajsík, M. Oriešková, M. Röderová, MA Gosney, ME Patrick, O Holý, O Holý, O. Holý, S Hariri, S Joseph, S Joseph, S Joseph, S Ravisankar, S. Forsythe, S. Hariri, SJ Forsythe, V. Hanulík, Y Sun   +34 more
core   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Revisitingmolecular serotyping of Streptococcus pneumoniae

BMC Genomics, 2015
BackgroundNinety-two Streptococcus pneumoniae serotypes have been described so far, but the pneumococcal conjugate vaccine introduced in the Brazilian basic vaccination schedule in 2010 covers only the ten most prevalent in the country.
D. R. Camargo, F. Pais, A. Volpini, M. A. Oliveira, R. Coimbra   +4 more
semanticscholar   +1 more source

Analysis of Erysipelothrix rhusiopathiae and Erysipelothrix tonsillarum by multilocus enzyme electrophoresis [PDF]

, 1994
The genetic diversity of 74 Australian field isolates of Erysipelothrix rhusiopathiae and 22 reference strains for serovars of E. rhusiopathiae or Erysipelothrix tonsillarum was examined by multilocus enzyme electrophoresis.
Chooromoney, K.N., Hampson, D.J., Eamens, G.J., Turner, M.J.   +3 more
core   +1 more source

Comparative genomic analysis and molecular examination of the diversity of enterotoxigenic Escherichia coli isolates from Chile [PDF]

, 2019
Enterotoxigenic Escherichia coli (ETEC) is one of the most common diarrheal pathogens in the low- and middle-income regions of the world, however a systematic examination of the genomic content of isolates from Chile has not yet been undertaken.
Del Canto, Felipe, Fleckenstein, James M, Hazen, Tracy H, Luo, Qingwei, Rasko, David A, Vidal, Roberto   +5 more
core   +2 more sources