Non-O157 shiga toxin-producing Escherichia coli (STEC) in Africa: a one health systematic review and meta-analysis of prevalence, antimicrobial resistance, and clinical outcomes. [PDF]
Sci RepAkinduti PA +5 more
europepmc +1 more source
Neuroprotection, EarlyView.Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji +4 more
wiley +1 more source
Genomic epidemiology and antimicrobial resistance profile of <i>Shigella</i> isolated from diarrhoea diseases in under-five children in Blantyre, Malawi. [PDF]
Microb GenomSibande GT +7 more
europepmc +1 more source
Enterovirus infections in children
Pediatric Investigation, EarlyView.Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen +11 more
wiley +1 more source
Botulinum toxin use in patients with neurological disorders: A U.S.‐based claims database analysis
PM&R, EarlyView.Abstract Background and Objective Real‐world evidence describing long‐term persistency with botulinum toxin (BoNT) therapy is limited. We assessed treatment patterns and persistency with BoNT in clinical practice over 2 years. Design Retrospective, longitudinal, claims database analysis. Setting Medical claims data from the Merative MarketScan database
David M. Simpson +4 more
wiley +1 more source
Phytotherapy Research, EarlyView.COR stabilizes GCH1 and inhibits ferroptosis. ABSTRACT To investigate the effects and targets of cordycepin (COR) in alleviating non‐alcoholic fatty liver disease (NAFLD). High‐fat diet was used to induce NAFLD in mice, and after COR gavage administration, changes in liver function, glucose and lipid metabolism, and ferroptosis‐related signaling were ...
Chenyang Han +7 more
wiley +1 more source
Synergistic Bactericidal Effects of R- and F-Type Pyocin Cocktails Against Clinical <i>Pseudomonas aeruginosa</i> Isolates from Central Taiwan. [PDF]
Antibiotics (Basel)Shen YL +6 more
europepmc +1 more source
Phytotherapy Research, EarlyView.PTA alleviates atherosclerosis by regulating the MDM2/GPX4 axis‐mediated endothelial ferroptosis. ABSTRACT Endothelial ferroptosis is a crucial pathogenic driver of atherosclerosis (AS) progression. Protosappanin A (PTA), a bioactive compound from Caesalpinia sappan L., protects cardiovascular vessels by regulating ferroptosis.
Jiamei Fu +6 more
wiley +1 more source
Molecular Epidemiology and Antimicrobial Resistance of Group B <i>Streptococcus</i> in Hainan, China: Genomic Insights from Perinatal and Adult Clinical Isolates. [PDF]
Infect Drug ResistZhao HM +9 more
europepmc +1 more source
Phytotherapy Research, EarlyView.Neohesperidin alleviates doxorubicin‐induced cardiotoxicity by inhibiting METTL3‐mediated m6A modification of Nrf2 mRNA, thereby regulating Nrf2 and suppressing ferroptosis. ABSTRACT Doxorubicin (DOX) has antitumor efficacy, but its clinical application is restricted by multiple side effects, especially cardiotoxicity.
Ruijia Wen +9 more
wiley +1 more source