Results 291 to 300 of about 69,583 (343)

AAV‐PHP.eB Peripheral Delivery and Central Expression in Cre Mice

Journal of Comparative Neurology, Volume 534, Issue 1, January 2026.
Retro‐orbital injection of AAV‐PHP.eB‐FLEX‐tdTomato into four different strains of Cre mice produced various and distinct patterns of transduction efficiency and tropism across brain regions and cell types. We found many target neurons expressing tdTomato in most but not all strains, along with a low level of nonspecific (Cre‐independent) expression ...
Haidong Zhu, Joel C. Geerling
wiley   +1 more source

Foot-and-mouth disease in Armenia (1958-2003): Historical epidemiology, serotype dynamics, and evolving vaccination strategies. [PDF]

Vet World
Voskanyan H, Simonyan L, Shahazizyan N, Mirzoyan M, Simonyan J, Markosyan T.   +5 more
europepmc   +1 more source

Dual AAV gene therapy achieves recovery of hearing and auditory processing in a DFNB16 mouse model

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
DFNB16 is among the most prevalent forms of congenital deafness, caused by mutations in the Stereocilin gene. Although no treatment currently exists, gene therapy represents a promising curative approach. Here, we demonstrate that AAV‐mediated gene delivery in a DFNB16 mouse model restored both peripheral hearing and central auditory processing ...
Sepideh Iranfar, Sophie Bagur, Chloé Felgerolle, Maxence Cornille, Najate Benamer, Hélène Le Ribeuz, Marie Giorgi, Sara Jamali, Amel Saoudi, Marie‐José Lecomte, Vincent Michel, Brice Bathellier, Saaid Safieddine   +12 more
wiley   +1 more source

Impact of PCV13 Vaccination on Pharyngeal Detection of <i>Streptococcus pneumoniae</i> Among Children - Suqian City, Jiangsu Province, China, February 2023-February 2025. [PDF]

China CDC Wkly
Ma L, Wei M, Wu T, Tao R, Gou J, Liu Y, Zhang M, Yuan M, Cui L, Li J.   +9 more
europepmc   +1 more source

Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Lactylation of ENO1 reduced the binding of TRIM21 mRNA to ENO1, thereby preventing mRNA degradation. Elevated TRIM21 subsequently binds to VE‐Cadherin, promoting its ubiquitination. Targeting the lactylation of ENO1 with a specific inhibitory peptide alleviated endothelial dysfunction.
Xueru Xie, Tingyan Liu, Caiyan Zhang, Ye Cheng, Yajing Gao, Wenfeng Xiao, Haiyan Guo, Yutong Zhou, Yawei Yu, Kexin Wang, Yinghong Lin, Lisheng Xiao, Yingying Zhang, Weiguo Yang, Gangfeng Yan, Guoping Lu, Yufeng Zhou   +16 more
wiley   +1 more source

Characterization of Haemophilus influenzae Obtained from Invasive Diseases in Cuban Children under Five Years of Age

Memorias do Instituto Oswaldo Cruz, 1999
Tamargo Isis, Toraño Gilda, Rodriguez Oxandra, Perez Miriam, Llop Alina   +4 more
doaj  

Prevalence of antibiotic-resistant <i>Salmonella</i> in kratom: Three-year monitoring study. [PDF]

Public Health Pract (Oxf)
Peroutka V, Demnerova K, Kadava J, Lencova S.   +3 more
europepmc   +1 more source

Astrocytic Igfbp2 Promotes Spontaneous Seizures in a Mouse Model of Mesial Temporal Lobe Epilepsy

Glia, Volume 74, Issue 1, January 2026.
Igfbp2 is upregulated in hippocampal astrocytes of MTLE model mice. Igfbp2 enhances dentate granule cell excitability. Astrocytic Igfbp2 deletion reduces spontaneous seizures. ABSTRACT Mesial temporal lobe epilepsy (MTLE) is a common, frequently drug‐resistant epilepsy characterized by seizures arising from the hippocampus.
Shinichi Kinoshita, Nobuyoshi Matsumoto, Shota Morikawa, Yuji Ikegaya, Ryuta Koyama   +4 more
wiley   +1 more source

Integrated analysis of O/K-antigen biosynthesis diversity and molecular serotyping scheme development of Vibrio alginolyticus. [PDF]

BMC Microbiol
Yu K, Huang Z, Li Y, Ma L, Bai X, Fu X, Kan B, Gao H.   +7 more
europepmc   +1 more source