Results 41 to 50 of about 809 (140)
Pre‐Existing Diabetes Alters Pulmonary Inflammatory Gene Expression Priming for Injury
The FASEB Journal, Volume 39, Issue 14, 31 July 2025.Diabetes mellitus (DM) is linked to cardiovascular complications, but its effects on lung health are less understood. Using a streptozotocin‐induced DM mouse model, we found that DM alone upregulated inflammatory pathways, disrupted endothelial integrity, and increased cytokine expression and lung fluid accumulation.
Abdulaziz H. Alanazi +5 more
wiley +1 more source
Protein Science, Volume 34, Issue 4, April 2025.Abstract While members of large paralogous protein families share structural features, their functional niches often diverge significantly. Serine protease inhibitors (SERPINs), whose members typically function as covalent inhibitors of serine proteases, are one such family.
Laura M. Haynes +4 more
wiley +1 more source
Relevance of obesity and overweight to salivary and plasma proteomes of human young adults from Brazil / Relevância da obesidade e sobrepeso para os proteomas salivares e plasmáticos de adultos jovens humanos do Brasil [PDF]
, 2022 Obesity is a chronic condition related to multiple comorbidities such as hypertension, type 2 diabetes, periodontal and cardiovascular diseases. Obesity can lead to a metabolic change, creating a prolonged and low-intensity inflammatory process.
da Silva, Carlos Vinicius Ferreira +5 more
core
Advanced Science, Volume 12, Issue 9, March 6, 2025.Most gene therapies function via manipulating hepatocytes, while it remains difficult to modulate macrophages and other non‐parenchymal cells. Fundamental cell biology is demonstrated, but not a lack of uptake accounts for the lack of translation: hepatocytes are polyploid cells and their polyploidy enables them to contain significantly higher amounts ...
Cheng Lin +22 more
wiley +1 more source
Przegląd Dermatologiczny, 2011 Introduction. Panniculitis is one of the rarest manifestations of α1-antitrypsin (AAT) deficiency. The disease is characterised by a typicalclinical picture with inflammatory tumours, necrosis, ulcerations, fistulasand oily liquid.
Michał Skroński +3 more
doaj
CREG1: Its Role as a Master Regulator of Liver Function [PDF]
, 2019 Mammalian development involves a complex system of regulatory signals and reactions resulting in highly differentiated cell types with specific structure and function.
Jahan, Iffat
core +1 more source
Alpha‐1 Antitrypsin Inclusions Sequester GRP78 in a Bile Acid–Inducible Manner
Liver International, Volume 45, Issue 1, January 2025.ABSTRACT Background and Aims The homozygous PiZ mutation (PIZZ genotype) constitutes the predominant cause of severe alpha‐1 antitrypsin (AAT) deficiency and leads to liver disease via hepatocellular AAT aggregation. We systematically analysed the composition of AAT aggregates and studied the impact of bile acids.
Igor Spivak +13 more
wiley +1 more source
Journal of Immunology Research, Volume 2025, Issue 1, 2025.Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria‐infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injury pathways have been
Lívia Rosa-Fernandes +9 more
wiley +1 more source
European Journal of Neuroscience, Volume 60, Issue 7, Page 5450-5466, October 2024.We studied the impact of circadian misalignment on 238 plasma proteins linked to cardiovascular physiology. We identified 42 proteins with altered abundance, five proteins regulated by the circadian clock, and changes in many proteins in the coagulation pathway.
Andrew W. McHill +3 more
wiley +1 more source
Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform
Journal of Pediatric Gastroenterology and Nutrition, Volume 78, Issue 5, Page 1047-1058, May 2024.Abstract Objectives Parenteral nutrition (PN) is used for patients of varying ages with intestinal failure to supplement calories. Premature newborns with low birth weight are at a high risk for developing PN associated liver disease (PNALD) including steatosis, cholestasis, and gallbladder sludge/stones.
Sean P. Harrison +6 more
wiley +1 more source