Results 41 to 50 of about 806 (131)

Treatment of severe stable COPD:the multidimensional approach of treatable traits [PDF]

, 2020
Now that additional treatment options for severe chronic obstructive pulmonary disease (COPD) have emerged in recent years, patients with severe COPD should not be left in the rather hopeless situation of "there is nothing to improve" any more.
Duiverman, Marieke L, Gan, Christiaan T, Kerstjens, Huib A M, Koster, T David, Slebos, Dirk-Jan, van der Vaart, Hester, van Dijk, Marlies, Wijkstra, Peter J   +7 more
core   +1 more source

Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure

ESC Heart Failure, Volume 12, Issue 5, Page 3296-3305, October 2025.
Abstract Aims Most proteomic analyses in patients with heart failure (HF) focus on the stable ambulatory setting; pathways that drive acute decompensated heart failure (ADHF) are largely uncharacterized. We aimed to examine the associations of cardiometabolic proteins with HF rehospitalization, mortality and diuretic response in patients with ADHF ...
Kenneth T. Hubbell, Veena S. Rao, Rebecca Scherzer, Michael G. Shlipak, Juan B. Ivery‐Miranda, Nisha Bansal, Zachary L. Cox, Jeffrey M. Testani, Michelle M. Estrella   +8 more
wiley   +1 more source

Pre‐Existing Diabetes Alters Pulmonary Inflammatory Gene Expression Priming for Injury

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Diabetes mellitus (DM) is linked to cardiovascular complications, but its effects on lung health are less understood. Using a streptozotocin‐induced DM mouse model, we found that DM alone upregulated inflammatory pathways, disrupted endothelial integrity, and increased cytokine expression and lung fluid accumulation.
Abdulaziz H. Alanazi, Mohamed S. Selim, Fang Liu, Duo Zhang, S. Priya Narayanan, Payaningal R. Somanath   +5 more
wiley   +1 more source

Relevance of obesity and overweight to salivary and plasma proteomes of human young adults from Brazil / Relevância da obesidade e sobrepeso para os proteomas salivares e plasmáticos de adultos jovens humanos do Brasil [PDF]

, 2022
Obesity is a chronic condition related to multiple comorbidities such as hypertension, type 2 diabetes, periodontal and cardiovascular diseases. Obesity can lead to a metabolic change, creating a prolonged and low-intensity inflammatory process.
da Silva, Carlos Vinicius Ferreira, da Silva-Boghossian, Carina Maciel, Leite, Paulo Emilio Correa, Sade, Youssef Bacila, Santos, Eidy de Oliveira, Scapin, Sandra Mara Naressi   +5 more
core  

High‐throughput amino acid‐level characterization of the interactions of plasminogen activator inhibitor‐1 with variably divergent proteases

Protein Science, Volume 34, Issue 4, April 2025.
Abstract While members of large paralogous protein families share structural features, their functional niches often diverge significantly. Serine protease inhibitors (SERPINs), whose members typically function as covalent inhibitors of serine proteases, are one such family.
Laura M. Haynes, Matthew L. Holding, Hannah L. DiGiovanni, David Siemieniak, David Ginsburg   +4 more
wiley   +1 more source

Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA

Advanced Science, Volume 12, Issue 9, March 6, 2025.
Most gene therapies function via manipulating hepatocytes, while it remains difficult to modulate macrophages and other non‐parenchymal cells. Fundamental cell biology is demonstrated, but not a lack of uptake accounts for the lack of translation: hepatocytes are polyploid cells and their polyploidy enables them to contain significantly higher amounts ...
Cheng Lin, Adrian Kuzmanović, Nan Wang, Liangliang Liao, Sabrina Ernst, Christian Penners, Alexander Jans, Thomas Hammoor, Petra Bumnuri Stach, Mona Peltzer, Ines Volkert, Elisabeth Zechendorf, Reham Hassan, Maiju Myllys, Christian Liedtke, Andreas Herrmann, Gurudas Chakraborty, Christian Trautwein, Jan Hengstler, Gerhard Müller‐Newen, Junqing Wang, Ahmed Ghallab, Matthias Bartneck   +22 more
wiley   +1 more source

Zapalenie tkanki podskórnej u nosicielki deficytowego wariantu S genu dla α1-antytrypsyny leczone skutecznie infliksymabem – opis przypadku

Przegląd Dermatologiczny, 2011
Introduction. Panniculitis is one of the rarest manifestations of α1-antitrypsin (AAT) deficiency. The disease is characterised by a typicalclinical picture with inflammatory tumours, necrosis, ulcerations, fistulasand oily liquid.
Michał Skroński, Jadwiga Roszkiewicz, Aleksandra Wilkowska, Agata Maciejewska-Radomska   +3 more
doaj  

Alpha‐1 Antitrypsin Inclusions Sequester GRP78 in a Bile Acid–Inducible Manner

Liver International, Volume 45, Issue 1, January 2025.
ABSTRACT Background and Aims The homozygous PiZ mutation (PIZZ genotype) constitutes the predominant cause of severe alpha‐1 antitrypsin (AAT) deficiency and leads to liver disease via hepatocellular AAT aggregation. We systematically analysed the composition of AAT aggregates and studied the impact of bile acids.
Igor Spivak, Nurdan Guldiken, Valentyn Usachov, Frank Schaap, Steven W.M. Olde Damink, Marion Bouchecareilh, Alexandra Lehmann, Lei Fu, Fa‐Rong Mo, Gökce Kobazi Ensari, Franziska Hufnagel, Malin Fromme, Christian Preisinger, Pavel Strnad   +13 more
wiley   +1 more source

CREG1: Its Role as a Master Regulator of Liver Function [PDF]

, 2019
Mammalian development involves a complex system of regulatory signals and reactions resulting in highly differentiated cell types with specific structure and function.
Jahan, Iffat
core   +1 more source

Serum Proteomics of Experimental Malaria‐Associated ARDS Reveals a Regulation of Acute‐Phase Response Proteins

Journal of Immunology Research, Volume 2025, Issue 1, 2025.
Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria‐infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injury pathways have been
Lívia Rosa-Fernandes, Verônica Feijoli Santiago, Yasmin da Silva-Santos, Tissiane Tarosso Lopes, Erika Paula Machado Peixoto, Stefani Aparecida Minchio Rodrigues, Claudio Romero Farias Marinho, Giuseppe Palmisano, Sabrina Epiphanio, Manish Goyal   +9 more
wiley   +1 more source