Results 31 to 40 of about 21,236,055 (153)
Przegląd Dermatologiczny, 2011 Introduction. Panniculitis is one of the rarest manifestations of α1-antitrypsin (AAT) deficiency. The disease is characterised by a typicalclinical picture with inflammatory tumours, necrosis, ulcerations, fistulasand oily liquid.
Michał Skroński +3 more
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Protein Science, Volume 34, Issue 4, April 2025.Abstract While members of large paralogous protein families share structural features, their functional niches often diverge significantly. Serine protease inhibitors (SERPINs), whose members typically function as covalent inhibitors of serine proteases, are one such family.
Laura M. Haynes +4 more
wiley +1 more source
Advanced Science, Volume 12, Issue 9, March 6, 2025.Most gene therapies function via manipulating hepatocytes, while it remains difficult to modulate macrophages and other non‐parenchymal cells. Fundamental cell biology is demonstrated, but not a lack of uptake accounts for the lack of translation: hepatocytes are polyploid cells and their polyploidy enables them to contain significantly higher amounts ...
Cheng Lin +22 more
wiley +1 more source
Alpha‐1 Antitrypsin Inclusions Sequester GRP78 in a Bile Acid–Inducible Manner
Liver International, Volume 45, Issue 1, January 2025.ABSTRACT Background and Aims The homozygous PiZ mutation (PIZZ genotype) constitutes the predominant cause of severe alpha‐1 antitrypsin (AAT) deficiency and leads to liver disease via hepatocellular AAT aggregation. We systematically analysed the composition of AAT aggregates and studied the impact of bile acids.
Igor Spivak +13 more
wiley +1 more source
Clonagem, expressão recombinante e caracterização de uma serpina da cana-de-açúcar [PDF]
, 2008 Financiadora de Estudos e ProjetosAs serpinas são conhecidos inibidores de serino proteases, enzimas notáveis por participarem de inúmeros processos fisiológicos importantes.
Silva, Kelly Pereira da
core
Journal of Immunology Research, Volume 2025, Issue 1, 2025.Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria‐infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injury pathways have been
Lívia Rosa-Fernandes +9 more
wiley +1 more source
European Journal of Neuroscience, Volume 60, Issue 7, Page 5450-5466, October 2024.We studied the impact of circadian misalignment on 238 plasma proteins linked to cardiovascular physiology. We identified 42 proteins with altered abundance, five proteins regulated by the circadian clock, and changes in many proteins in the coagulation pathway.
Andrew W. McHill +3 more
wiley +1 more source
Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform
Journal of Pediatric Gastroenterology and Nutrition, Volume 78, Issue 5, Page 1047-1058, May 2024.Abstract Objectives Parenteral nutrition (PN) is used for patients of varying ages with intestinal failure to supplement calories. Premature newborns with low birth weight are at a high risk for developing PN associated liver disease (PNALD) including steatosis, cholestasis, and gallbladder sludge/stones.
Sean P. Harrison +6 more
wiley +1 more source
Physiological Reports, Volume 12, Issue 6, March 2024.Abstract Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular ...
Hiroyuki Natsui +27 more
wiley +1 more source
Revista Colombiana de Obstetricia y Ginecología, 2011 Introducción: la preeclampsia constituye una causa importante de morbimortalidad materna y perinatal en el mundo. Su etiopatogenia es aún un enigma; sin embargo, los avances en genómica y proteómica prometen la identificación temprana de la enfermedad o ...
Augusto Valderrama-Aguirre +2 more
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