Results 21 to 30 of about 21,236,055 (153)

Changes on proteomic and metabolomic profile in serum of mice induced by chronic exposure to tramadol

Scientific Reports, 2021
Tramadol is an opioid used as an analgesic for treating moderate or severe pain. The long-term use of tramadol can induce several adverse effects. The toxicological mechanism of tramadol abuse is unclear. Limited literature available indicates the change
Shukun Jiang, Guojie Liu, Huiya Yuan, Enyu Xu, Wei Xia, Xiaoyu Zhang, Junting Liu, Lina Gao   +7 more
doaj   +1 more source

The diuretic torasemide does not prevent aldosterone-mediated mineralocorticoid receptor activation in cardiomyocytes.

PLoS ONE, 2013
Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid signaling is deleterious during the evolution of cardiac failure, as evidenced by the benefits
Basile Gravez, Antoine Tarjus, Ruben Jimenez-Canino, Soumaya El Moghrabi, Smail Messaoudi, Diego Alvarez de la Rosa, Frederic Jaisser   +6 more
doaj   +1 more source

Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren’s syndrome condition

Autoimmunity, 2020
Primary Sjogren’s syndrome (pSS) is a systemic autoimmune disease that is characterized by the infiltration of immune cells. Although the loss of salivary gland function is a major manifestation observed in pSS, the factors that could promote these ...
Brij B. Singh, Joyce Ohm, Fredice O. Quenum Zanbede, Pooja Chauhan, Frans G. M. Kroese, Arjan Vissink, Julian L. Ambrus, Bibhuti B. Mishra   +7 more
doaj   +1 more source

E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis

Toxics, 2020
E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a “healthy method” of tobacco consumption.
Anas A. Ashour, Hashim Alhussain, Umar Bin Rashid, Labiba Abughazzah, Ishita Gupta, Ahmed Malki, Semir Vranic, Ala-Eddin Al Moustafa   +7 more
doaj   +1 more source

The Genetic Predisposition and Its Impact on the Diabetes Mellitus Development in Patients with Alcoholic Chronic Pancreatitis

Gastroenterology Research and Practice, 2015
The most common cause of chronic pancreatitis (CP) is alcohol abuse. The aim of the present study was to identify patients with genetic predisposition to CP abusing alcohol.
Agnieszka Madro, Marzanna Ciesielka, Krzysztof Celinski, Maria Slomka, Grazyna Czechowska, Jacek Kurzepa, Beata Kaszelan-Szczerbinska, Grzegorz Buszewicz, Roman Madro   +8 more
doaj   +1 more source

Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li, Yuezhou Wu, Zhu'anzhen Zheng, Fengjin Zhou, Ke Xu, Jiacan Su   +5 more
wiley   +1 more source

Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.

PLoS ONE, 2013
Genome-wide association (GWA) studies have been limited by the reliance on common variants present on microarrays or imputable from the HapMap Project data.
Andrew R Wood, John R B Perry, Toshiko Tanaka, Dena G Hernandez, Hou-Feng Zheng, David Melzer, J Raphael Gibbs, Michael A Nalls, Michael N Weedon, Tim D Spector, J Brent Richards, Stefania Bandinelli, Luigi Ferrucci, Andrew B Singleton, Timothy M Frayling   +14 more
doaj   +1 more source

Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease

Aging Cell, Volume 24, Issue 11, November 2025.
Targeting muscle with Cathepsin B (Ctsb) to treat the AD mouse brain. In this study, an AAV‐vector‐mediated approach, utilized to express Ctsb in muscle, prevented mnemonic and neurogenic deficits and normalized hippocampal, muscle, and plasma proteomic profiles.
Alejandro Pinto, Hazal Haytural, Cássio Morais Loss, Claudia Alvarez, Asude Ertas, Olivia Curtis, Alyssa R. Williams, Grayson Murphy, Kenneth J. Salleng, Sylvia Gografe, Nishant P. Visavadiya, Andy V. Khamoui, Ali Altıntaş, Tal Kafri, Romain Barres, Atul S. Deshmukh, Henriette van Praag   +16 more
wiley   +1 more source

Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure

ESC Heart Failure, Volume 12, Issue 5, Page 3296-3305, October 2025.
Abstract Aims Most proteomic analyses in patients with heart failure (HF) focus on the stable ambulatory setting; pathways that drive acute decompensated heart failure (ADHF) are largely uncharacterized. We aimed to examine the associations of cardiometabolic proteins with HF rehospitalization, mortality and diuretic response in patients with ADHF ...
Kenneth T. Hubbell, Veena S. Rao, Rebecca Scherzer, Michael G. Shlipak, Juan B. Ivery‐Miranda, Nisha Bansal, Zachary L. Cox, Jeffrey M. Testani, Michelle M. Estrella   +8 more
wiley   +1 more source

Pre‐Existing Diabetes Alters Pulmonary Inflammatory Gene Expression Priming for Injury

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Diabetes mellitus (DM) is linked to cardiovascular complications, but its effects on lung health are less understood. Using a streptozotocin‐induced DM mouse model, we found that DM alone upregulated inflammatory pathways, disrupted endothelial integrity, and increased cytokine expression and lung fluid accumulation.
Abdulaziz H. Alanazi, Mohamed S. Selim, Fang Liu, Duo Zhang, S. Priya Narayanan, Payaningal R. Somanath   +5 more
wiley   +1 more source