Results 11 to 20 of about 21,236,055 (153)
BiologicsBackground and Objectives: The cytokine IL-6, methyltransferase NSD2, pro-protein convertase Furin, and growth factor receptor IGF-1R are essential factors in the proliferation of cancer cells.
Nassim Tassou +3 more
doaj +3 more sources
Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels. [PDF]
PLoS Genetics, 2013 Several infrequent genetic polymorphisms in the SERPINA1 gene are known to substantially reduce concentration of alpha1-antitrypsin (AAT) in the blood.
Gian Andri Thun +42 more
doaj +2 more sources
Serpin Peptidase Inhibitor Clade A Member 1 (SerpinA1) Is a Novel Biomarker for Progression of Cutaneous Squamous Cell Carcinoma [PDF]
The American Journal of Pathology, 2011 The incidence of keratinocyte-derived nonmelanoma skin cancers is increasing worldwide because of cumulative recreational exposure to sunlight. At present, no specific molecular markers are available for assessing the progression of premalignant actinic keratoses to invasive cutaneous squamous cell carcinoma (SCC).
Farshchian, Mehdi +9 more
openaire +4 more sources
COVID-19 Pathology Sheds New Light on Balance between Neutrophil Proteases and Their Inhibitors
, 2022 El carcinoma Escamoso de Cabeza y Cuello (CECC) es el sexto cáncer con mayor incidencia en países desarrollados. Dos terceras partes de los pacientes con Carcinoma Escamoso de Cabeza y Cuello (CECC) se diagnostican en estadios avanzados y no siempre responden al tratamiento habitual de quimioterapia combinada con cirugía o radioterapia.
Radic M, Silva VV.
europepmc +3 more sources
Collagen constitutes about 12% in females and 17% in males of the total protein in mice
Scientific Reports, 2023 Collagen has been postulated to be the most abundant protein in our body, making up one-third of the total protein content in mammals. However, a direct assessment of the total collagen levels of an entire mammal to confirm this estimate is missing. Here
Katharina Tarnutzer +3 more
doaj +1 more source
Revista Colombiana de Obstetricia y Ginecología, 2011 Introducción: la preeclampsia constituye una causa importante de morbimortalidad materna y perinatal en el mundo. Su etiopatogenia es aún un enigma; sin embargo, los avances en genómica y proteómica prometen la identificación temprana de la enfermedad o ...
Augusto Valderrama-Aguirre +2 more
doaj +3 more sources
Topical emollient prevents the development of atopic dermatitis and atopic march in mice
Experimental Dermatology, Volume 32, Issue 7, Page 1007-1015, July 2023., 2023 Abstract To investigate the effect of emollient on atopic march in a murine model of atopic dermatitis (AD). Following induction of AD with topical calcipotriol (MC903) and ovalbumin (OVA), one group of mice was treated topically with a linoleic acid‐ceramide‐containing emollient, while mice without emollient treatment served as disease controls. After
Jiayi Zhang +7 more
wiley +1 more source
The RNA‐binding protein Snd1/Tudor‐SN regulates hypoxia‐responsive gene expression
FASEB BioAdvances, Volume 5, Issue 5, Page 183-198, May 2023., 2023 Our results show that in normal growth conditions Snd1 is not a critical factor for mRNA transcription in the mouse and describe a function for Snd1 in hypoxia adaptation through negatively regulating hypoxia‐related miRNAs and hypoxia‐induced transcription consistent with a role as stress response regulator.
Juha Saarikettu +9 more
wiley +1 more source
Respiratory Research, 2018 Background The pathophysiological role of SERPINA1 in respiratory health may be more strongly determined by the regulation of its expression than by common genetic variants.
Anna Beckmeyer-Borowko +22 more
doaj +1 more source
Defining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation. [PDF]
PLoS ONE, 2012 Certain concepts concerning EPO/EPOR action modes have been challenged by in vivo studies: Bcl-x levels are elevated in maturing erythroblasts, but not in their progenitors; truncated EPOR alleles that lack a major p85/PI3K recruitment site nonetheless ...
Seema Singh +7 more
doaj +1 more source