Identification of a novel SERPINA-1 mutation causing alpha-1 antitrypsin deficiency in a patient with severe bronchiectasis and pulmonary embolism [PDF]
International Journal of COPD, 2015 Katrin Milger,1 Lesca Miriam Holdt,2 Daniel Teupser,2 Rudolf Maria Huber,1 Jürgen Behr,1 Nikolaus Kneidinger1 1Department of Internal Medicine V, University of Munich, Comprehensive Pneumology Center, Member of the German Center for Lung Research ...
Milger K +5 more
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COVID-19 Pathology Sheds Further Light on Balance between Neutrophil Proteases and Their Inhibitors [PDF]
Biomolecules, 2022 Excessive neutrophil influx and activation in lungs during infections, such as manifest during the ongoing SARS CoV-2 pandemic, have brought neutrophil extracellular traps (NETs) and the concomitant release of granule contents that damage surrounding ...
Vasuki Silva, Marko Radic
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The glia-immune network: Astrocytes and oligodendrocytes as microglial co-ordinators in health and disease. [PDF]
J PhysiolAbstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Mitchener VFT +2 more
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Pi∗S and Pi∗Z Alleles of SERPINA1 Gene Are Associated With Specific Variants of a BRD4-Independent Enhancer. [PDF]
Hum MutatAlpha‐1 antitrypsin deficiency (AATD) is a genetic disorder caused by specific variants in the SERPINA1 gene, which encodes AAT. The most common disease‐associated SERPINA1 variants are Pi ∗ S and Pi ∗ Z alleles, which cause moderate and severe AATD, respectively. Recent studies have reported the presence of a possible regulator of SERPINA gene cluster
Escuela-Escobar A +5 more
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A Potential Novel Molecular Interaction in Bronchiolitis Obliterans Syndrome in Lung Transplantation Patients: The Role of SERPINA3 and Osteoprotegerin. [PDF]
FASEB JSerum SERPINA3 levels were higher in BOS compared to non‐BOS patients. OPG and SERPINA3 positive cells colocalized with tryptase positive mast cells in airways from BOS lung tissue. OPG and SERPINA3 staining positively correlated in partially and completely obstructed airways.
Liu Y +8 more
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Proteomics-based approach for differentiation of age-related macular degeneration sub-types [PDF]
Indian Journal of Ophthalmology, 2021 Purpose: Age-related macular degeneration (AMD) is one of the leading causes of irreversible central vision loss in the elderly population. The current study aims to find non-invasive prognostic biomarkers in the urine specimens of the AMD patients ...
Sivapriya Sivagurunathan +16 more
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Alpha-1 Antitrypsin Deficiency Beyond COPD and Emphysema: A Narrative Review [PDF]
Medical SciencesBackground/Objectives: Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder classically associated with emphysema and COPD. However, emerging evidence indicates that its clinical spectrum extends to airway-predominant diseases such as ...
Lucia Pastoressa +6 more
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A research on the mechanism of SERPINA3 promoting malignant progression and gemcitabine resistance of pancreatic cancer by inhibiting ferroptosis [PDF]
Zhongguo aizheng zazhiBackground and purpose: Members of the serine protease inhibitor (SERPIN) family can influence tumorigenesis, progression, and prognosis by modulating processes such as apoptosis, invasion, metastasis, and angiogenesis in tumor cells. However, their role
HE Yuan, GUO Juncheng, YE Zhibin, WANG Xiaohu, LI Haonan, HUANG Jingbiao
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Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance
Anais da Academia Brasileira de Ciências, 2021 Fibromyalgia (FM) is a chronic pain syndrome that affects the central nervous system and generates disability, which is characterized by generalized pain, fatigue, and functional decline.
LUÍSA P. JANSSEN +3 more
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Biochemistry and Biophysics Reports, 2021 Obesity-induced endoplasmic reticulum (ER) stress contributes to low-grade chronic inflammation in adipose tissue and may cause metabolic disorders such as diabetes mellitus and dyslipidemia.
Yukari Ando +5 more
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