Results 51 to 60 of about 806 (131)
Exercise-driven metabolic pathways in healthy cartilage [PDF]
, 2016 ObjectiveExercise is vital for maintaining cartilage integrity in healthy joints. Here we examined the exercise-driven transcriptional regulation of genes in healthy rat articular cartilage to dissect the metabolic pathways responsible for the potential ...
Agarwal, S +11 more
core +1 more source
European Journal of Neuroscience, Volume 60, Issue 7, Page 5450-5466, October 2024.We studied the impact of circadian misalignment on 238 plasma proteins linked to cardiovascular physiology. We identified 42 proteins with altered abundance, five proteins regulated by the circadian clock, and changes in many proteins in the coagulation pathway.
Andrew W. McHill +3 more
wiley +1 more source
Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform
Journal of Pediatric Gastroenterology and Nutrition, Volume 78, Issue 5, Page 1047-1058, May 2024.Abstract Objectives Parenteral nutrition (PN) is used for patients of varying ages with intestinal failure to supplement calories. Premature newborns with low birth weight are at a high risk for developing PN associated liver disease (PNALD) including steatosis, cholestasis, and gallbladder sludge/stones.
Sean P. Harrison +6 more
wiley +1 more source
Structural and functional characterization of SARS-CoV-2 AY.33 variant spike [PDF]
, 2023 52 p.El COVID-19 se ha convertido en la mayor pandemia del siglo XXI registrada hasta la fecha. Esta enfermedad es provocada por la infección del virus SARS-CoV-2, virus de la familia Coronaviridae que entra en las células huésped mediante la unión ...
García Soto, María del Mar
core
Physiological Reports, Volume 12, Issue 6, March 2024.Abstract Epicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular ...
Hiroyuki Natsui +27 more
wiley +1 more source
A challenging diagnosis of alpha-1-antitrypsin deficiency: identification of a patient with a novel F/Null phenotype [PDF]
, 2011 Alpha-1-antitrypsin (A1AT) deficiency is a genetic disease characterized by low levels and/or function of A1AT protein. A1AT deficiency can result in the development of COPD, liver disease, and certain skin conditions.
Michael R Ringenbach +4 more
core +2 more sources
Molecular Ecology, Volume 33, Issue 2, January 2024.Abstract Health information is essential for the conservation management of whale species. However, assessing the health of free‐ranging whales is challenging as samples are primarily limited to skin and blubber tissue. Reverse transcription quantitative polymerase chain reaction (RT‐qPCR) offers a method to measure health from blubber RNA, providing ...
Jacob M. J. Linsky +2 more
wiley +1 more source
Revista Colombiana de Obstetricia y Ginecología, 2011 Introducción: la preeclampsia constituye una causa importante de morbimortalidad materna y perinatal en el mundo. Su etiopatogenia es aún un enigma; sin embargo, los avances en genómica y proteómica prometen la identificación temprana de la enfermedad o ...
Augusto Valderrama-Aguirre +2 more
doaj
Impact of Gene Modifiers on Cystic Fibrosis Phenotypic Profiles: A Systematic Review
Human Mutation, Volume 2024, Issue 1, 2024.Cystic fibrosis (CF) is a complex monogenic disorder with a large variability in disease severity. Growing evidence suggests that the variation observed depends not only on variations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene but also on modifier genes.
Anastasia Ward +4 more
wiley +1 more source
PLoS Neglected Tropical DiseasesAcute kidney injury (AKI) is a critical systemic complication caused by Bothrops envenoming, a neglected health problem in the Brazilian Amazon. Understanding the underlying mechanisms leading to AKI is crucial for effectively mitigating the burden of ...
Lisele Maria Brasileiro-Martins +17 more
doaj +1 more source