Results 151 to 160 of about 8,184 (185)
Specific Cerebrospinal Fluid SerpinA1 Isoform Pattern in Alzheimer’s Disease
International Journal of Molecular Sciences, 2022 SerpinA1 (α1-antitrypsin) is a soluble glycoprotein, the cerebrospinal fluid (CSF) isoforms of which showed disease-specific changes in neurodegenerative disorders that are still unexplored in Alz-heimer’s disease (AD).
Federico Massa, Lucilla Parnetti
exaly +6 more sources
SERPINA1 gene polymorphisms in a population‐based ALSPAC cohort [PDF]
Pediatric Pulmonology, 2019 Background: There is an association between persistent preschool wheezing phenotypes and school-age asthma. These wheezing/asthma phenotypes likely represent clinical entities having specific genetic risk factors.
Vaida Taminskiene +2 more
exaly +11 more sources
In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis [PDF]
International Journal of Molecular Sciences, 2021 Transthyretin (TTR) proteolysis has been recognized as a complementary mechanism contributing to transthyretin-related amyloidosis (ATTR amyloidosis). Accordingly, amyloid deposits can be composed mainly of full-length TTR or contain a mixture of both ...
Paula Isabel Meira Gonçalves +2 more
exaly +8 more sources
Clinical Significance of SERPINA1 Gene and Its Encoded Alpha1-antitrypsin Protein in NSCLC [PDF]
Cancers, 2019 : High expression of SERPINA1 gene encoding acute phase protein, alpha1-antitrypsin (AAT), is associated with various tumors. We sought to examine the significance of SERPINA1 and AAT protein in non-small-cell lung cancer (NSCLC) patients and NSCLC cell ...
Beatriz Martinez Delgado +2 more
exaly +3 more sources
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Granularity ofSERPINA1alleles by DNA sequencing in CanCOLD
European Respiratory Journal, 2020DNA sequencing of theSERPINA1gene to detect α1-antitrypsin (AAT) deficiency (AATD) may provide a better appreciation of the individual and cumulative impact of genetic variants on AAT serum levels and COPD phenotypes.AAT serum level and DNA sequencing of the coding regions ofSERPINA1were performed in 1359 participants of the Canadian Cohort Obstructive
Nisha Gupta +9 more
openaire +2 more sources
SERPINA1 Gene Variants in Granulomatosis with Polyangiitis
2018Alpha-1 antitrypsin (A1AT) deficiency is one of the most common genetic disorders in Caucasian population. There is a link between granulomatosis with polyangiitis (GPA) and most frequent variants of SERPINA1 gene encoding severe alpha-1 antitripsin deficiency.
Malgorzata, Hadzik-Blaszczyk +8 more
openaire +2 more sources
SERPINA1, generalized pustular psoriasis, and adult‐onset immunodeficiency
The Journal of Dermatology, 2021AbstractAdult‐onset immunodeficiency syndrome (AOID) with anti‐interferon (IFN)‐γ autoantibodies is characterized by an AIDS‐like illness with disruptive IFN‐γ signaling. Patients generally present with recurrent and disseminated opportunistic infections along with neutrophilic dermatoses.
Piranit Kantaputra +11 more
openaire +3 more sources
Functional characterization of the mouse Serpina1 paralog DOM-7
Biological Chemistry, 2018Abstract The generation of authentic mouse-models for human α1-antitrypsin (A1AT)-deficiency is difficult due to the high complexity of the mouse Serpina1 gene locus. Depending on the exact mouse strain, three to five paralogs are expressed, with different proteinase inhibitory properties.
Karen Jülicher +10 more
openaire +2 more sources
Protease inhibitor SERPINA1 expression in epithelial ovarian cancer
Clinical & Experimental Metastasis, 2010Epithelial ovarian cancer is the most lethal gynecologic cancer with a 5 years survival rate of 30-40% in patients diagnosed with high-grade invasive disease (TOV). This is in stark contrast to the 95% 5 years survival rate in ovarian cancer patients diagnosed with low malignant potential (LMP) disease.
Karine, Normandin +7 more
openaire +2 more sources