Immunoregulation mediated by the enzyme inhibitory activity of helminth-derived serine protease inhibitor affects the protective efficiency of vaccines. [PDF]
Shi W +8 more
europepmc +1 more source
Genome resequencing and genome-wide polymorphisms in mosquito vectors Aedes aegypti and Aedes albopictus from south India. [PDF]
Acharya P +5 more
europepmc +1 more source
Functional mass spectrometry indicates anti-protease and complement activity increase with COVID-19 severity. [PDF]
Fraser DD +8 more
europepmc +1 more source
Serine protease inhibitor, SerpinA3n, regulates cardiac remodelling after myocardial infarction. [PDF]
Sun Q +13 more
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SerpinB3/Protease Activated Receptor-2 Axis Is Essential for SARS CoV-2 Infection. [PDF]
Frasson I +9 more
europepmc +1 more source
Genome sequences of four Ixodes species expands understanding of tick evolution. [PDF]
Cerqueira de Araujo A +31 more
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Plasminogen activator inhibitor type 2 : a unique serpin with two mobile loops
Sergei Lobov
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Integrative view of serpins in health and disease: the contribution of serpinA3.
American Journal of Physiology - Cell Physiology, 2020Serpins are a superfamily of proteins characterized by their common function as serine protease inhibitors. So far, 36 serpins from nine clades have been identified.
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Mutagenesis represents a powerful methodology for the analysis of protein structural and functional relationships and dissection of complex protein-protein interactions. The suicide substrate-like inhibitory mechanism of the proteins of the serpin superfamily offers unique challenges for the design of mutagenesis studies.
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