Results 271 to 280 of about 20,002 (295)

Maspin: A Tumor Suppressing Serpin

1996
Maspin, a serpin found in mammary epithelial cells, has been shown to have tumor suppressor activity. The gene is expressed in normal human mammary epithelial cells but down-regulated in invasive breast carcinomas. Similar patterns of expression at the RNA and protein levels are seen by Northern analysis with cells grown in culture and by ...
Mary J.C. Hendrix, Ruth Sager, Shijie Sheng, Philip A. Pemberton   +3 more
openaire   +4 more sources

Evolutionary history of the uterine serpins

Journal of Experimental Zoology, 2000
A bioinformatics analysis was conducted on the four members of the uterine serpin (US) family of serpins. Evolutionary analysis of the protein sequences and 86 homologous serpins by maximum parsimony and distance methods indicated that the uterine serpins proteins form a clade distinct from other serpins.
Steven A. Benner, David A. Liberles, Morgan R. Peltier, Peter J. Hansen, Lee C. Raley   +4 more
openaire   +3 more sources

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins.

Biochemistry, 1989
Article synthese sur l'α1-antitrypsine: caracteristiques structurales et fonctionnelles (capacite de liaison a des modulateurs); utilisation de l'α1-antitrypsine en tant que modele pour toutes les ...
R. Huber, Carrell Rw
semanticscholar   +1 more source

Conformational pathology of the serpins: themes, variations, and therapeutic strategies.

Annual Review of Biochemistry, 2009
Point mutations cause members of the serine protease inhibitor (serpin) superfamily to undergo a novel conformational transition, forming ordered polymers. These polymers characterize a group of diseases termed the serpinopathies.
B. Gooptu, D. Lomas
semanticscholar   +1 more source

Antiplasmin

The FEBS Journal, 2005
Much of the basic biochemistry of antiplasmin was described more than 20 years ago and yet it remains an enigmatic member of the serine protease inhibitor (serpin) family. It possesses all of the characteristics of other inhibitory serpins but in addition it has unique N‐ and C‐terminal extensions which significantly modify its activities.
openaire   +3 more sources

The Serpin Shield

Science Translational Medicine, 2014
Serpins help breast and lung cancer cells metastasize to the brain by annulling stromal defenses and co-opting capillaries.
openaire   +2 more sources

Cystatins, serpins and other families of protease inhibitors in plants.

Current protein and peptide science, 2011
Plant protease inhibitors (PIs) are generally small proteins present in high concentrations in storage tissues (tubers and seeds), and to a lower level in leaves.
M. Volpicella, C. Leoni, A. Costanza, F. De Leo, R. Gallerani, L. Ceci   +5 more
semanticscholar   +1 more source

Serpins in plants and green algae

Functional & Integrative Genomics, 2007
Control of proteolysis is important for plant growth, development, responses to stress, and defence against insects and pathogens. Members of the serpin protein family are likely to play a critical role in this control through irreversible inhibition of endogenous and exogenous target proteinases. Serpins have been found in diverse species of the plant
Jørn Hejgaard, Thomas H. Roberts
openaire   +3 more sources

Serpin Structure, Mechanism, and Function

Chemical Reviews, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +4 more sources

Serpins in Caenorhabditis elegans

2015
C. elegans is an extremely powerful model organism to study gene function and biology. The nematodes’ genetic tractability and high degree of genetic similarity with humans make it ideal to study the biologic role of serpins. The endogenous C. elegans serpins are most similar to the human clade B or intracellular serpin family and have a predominantly ...
Cliff J. Luke, Gary A. Silverman, Allyson N. Wyatt, Stephen C. Pak, Linda P. O’Reilly, Mark T. Miedel, Ryan R. Knoerdel   +6 more
openaire   +2 more sources