Results 281 to 290 of about 20,002 (295)

Serpins Save Cells

Science's STKE, 2007
Biologically active proteases are held in check in part by a family of peptidase inhibitors known as serpins. Most serpins are secreted proteins, but some are intracellular proteins implicated in regulating lysosomal proteases. Knockout mice have failed to reveal the biological roles of these inhibitors, though--possibly because mice have ...
openaire   +2 more sources

Inflammation and Noninhibitor Serpins

1997
Pigment epithelium-derived factor (PEDF) is a member of the serpin family with neurotrophic activity. However, PEDF belongs to the non-inhibitory subgroup of serpins and its neurotrophic activity does not require inhibition of proteases. PEDF induces neuronal survival on cerebellar granule cell neurons and neurite-outgrowth on retinoblastoma cells ...
Elena Alberdi, S. Patricia Becerra
openaire   +2 more sources

Serpins and Regulation of Cell Death

1998
Proteolysis is a key feature of programmed cell death. Extracellular proteinases can activate cell surface receptors which trigger apoptosis, and the effector machinery requires the activation and activity of numerous intracellular proteinases (primarily caspases).
openaire   +3 more sources

Overview of Serpins and Their Roles in Biological Systems.

Methods in molecular biology, 2018
A. Lucas, Jordan R. Yaron, Liqiang Zhang, Sriram Ambadapadi   +3 more
semanticscholar   +1 more source

Genetic engineering and the serpins

BioEssays, 1988
Robin W. Carrell, D. Ross Boswell
openaire   +3 more sources

The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins

Journal of Biological Chemistry, 2001
G. Silverman, P. Bird, R. Carrell, F. Church, P. Coughlin, P. Gettins, J. Irving, D. Lomas, C. J. Luke, R. Moyer, P. Pemberton, E. Remold-O’Donnell, G. Salvesen, J. Travis, J. Whisstock   +14 more
semanticscholar   +1 more source

Role of heparin and non heparin binding serpins in coagulation and angiogenesis: A complex interplay.

Archives of Biochemistry and Biophysics, 2016
Teena Bhakuni, Mohammad Farhan Ali, Irshad Ahmad, Shadabi Bano, Shoyab Ansari, M. A. Jairajpuri   +5 more
semanticscholar   +1 more source

The role of serpins in tumor cell migration

Biological chemistry, 2015
Y. Fortenberry
semanticscholar   +1 more source

Serpins, Immunity and Autoimmunity: Old Molecules, New Functions

Clinical reviews in allergy and immunology, 2013
M. Gatto, L. Iaccarino, A. Ghirardello, N. Bassi, P. Pontisso, L. Punzi, Y. Shoenfeld, A. Doria   +7 more
semanticscholar   +1 more source

A novel serpin (FC-SERPIN) in Chinese shrimp, Fenneropenaeus chinensis

Journal of Biotechnology, 2008
Xiaojun Zhang, Fuhua Li, Jianhai Xiang, Bing Wang, Bo Dong, Yichen Liu   +5 more
openaire   +2 more sources