Results 181 to 190 of about 3,295,861 (246)

Histopathological Spectrum and Yield of Advanced Neoplasia in Opportunistic Colonoscopy Without Organised Screening: A Single-Centre Cross-Sectional Study from Western Romania. [PDF]

Diagnostics (Basel)
Anton A, Brebu D, Bugi MA, Neamțu AA, Căpraru AM, Zurbău-Anghel N, Iovănescu D, Maghiar TA, Pașca P, Faur FI, Chiriac SD, Iliescu D, Totolici BD, Crețu O, Dehelean CA, Neamțu C.   +15 more
europepmc   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

The adverse effects of non-invasive high-frequency oscillatory ventilation on the cerebral hemodynamics of premature infants: point-of-care brain ultrasound findings from a case-series study. [PDF]

Front Pediatr
Liu J, Fu W, Liu Y.
europepmc   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Evaluation of serrated lesion detection using different indicators: a single-centre, community-based, retrospective cohort study. [PDF]

BMJ Open Gastroenterol
Denis B, Catinat V, Plastaras L, Amaritei I, Bolliet M, Clavel M, Darrius R, Montet P, Vuola S, Simomia Mbowen L, Hammas K.   +10 more
europepmc   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Microbiota-assisted screening for colorectal neoplasia: advanced adenoma as the key translational endpoint-a narrative review. [PDF]

Am J Transl Res
Wang X, Li J, Cheng Y, Liu Y, Li H, Tan H, Hu Y, Zhao M, Liu J.   +8 more
europepmc   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

The association of sedentary time and physical activity with colorectal adenoma: A colonoscopy-based study. [PDF]

J Chin Med Assoc
Lin CC, Chen HJ, Wang YW, Chang CY, Huang SS, Hsu PF, Liou TL, Leu HB.   +7 more
europepmc   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source