Results 191 to 200 of about 3,295,861 (246)

Development of an energy consumption map for turning inconel 718 through coupled chip-morphology and material-deformation analysis. [PDF]

Sci Rep
Khan MA, Ahmad R, Haq MRU, Jaffery SHI, Zahid D.   +4 more
europepmc   +1 more source

Improved Deformability of Co‐Free Medium Entropy Oxides by Controlled Entropy Destabilization

Advanced Science, EarlyView.
Controlled entropy destabilization activates defect‐mediated plasticity in Co‐free (CuMgNiZn)O by promoting pre‐existing Cu‐rich secondary phases that serve as defect sources. Temperature‐dependent dislocation activity evolves from limited motion at room temperature to extensive glide and stacking‐fault formation at 600 °C, enabling improved plasticity
Chang Liu, Ke Xu, Zhongxia Shang, Yang Chen, Debargha Paul, Yinghang Liu, Jeremy Gan, Shiyu Zhou, R. Edwin García, Xinghang Zhang, Haiyan Wang   +10 more
wiley   +1 more source

Diagnostic Performance of High-Frequency Ultrasound and Ultra-High-Frequency Ultrasound in Distinguishing Dermatofibrosarcoma Protuberans from Dermatofibroma: A 15-year Period Retrospective Analysis. [PDF]

Clin Cosmet Investig Dermatol
Chen G, Luo H, Liu W, Liao X, Meng J, Qiu Z, Leng X.   +6 more
europepmc   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

Structured Cap-assisted Margin Assessment Reduces Residual Neoplasia after Colorectal Polypectomy: A Prospective Multicentre Proof-of-Concept Study. [PDF]

Endosc Int Open
Huelsen A, Willis T, Ketheson P, Cooper C, Borowsky J, Pillay S, Hughes IP, Hamarneh Z.   +7 more
europepmc   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Environmental Impact of Conventional Versus Underwater Endoscopic Mucosal Resection for Colorectal Lesions: A Procedure-Based Life Cycle Assessment With Pooled Effectiveness Estimates. [PDF]

DEN Open
Calabrese G, Moll F, Neves JAC, Bonacci L, Sinagra E, Castiglione F, Maida M, Albéniz-Arbizu E, Pioche M, Sferrazza S.   +9 more
europepmc   +1 more source

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source