Frontiers in Endocrinology, 2022 Since their initial description by Enrico Sertoli in 1865, Sertoli cells have continued to enchant testis biologists. Testis size and germ cell carrying capacity are intimately tied to Sertoli cell number and function.
Victor A. Ruthig +3 more
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RU 486 blocks inhibitory effect of neonatal corticosterone administration on sertoli cell proliferation in mice [PDF]
Scientific ReportsCortisol/corticosterone (CORT) are typical glucocorticoids and exert an anti-stress function. p27, a cyclin-dependent kinase inhibitor, acts as a terminal factor for Sertoli cell proliferation at the prepubescent stage. Our previous study showed neonatal
Hidenobu Miyaso +10 more
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Scientific Reports, 2022 The Sertoli cell (SC)-specific knockout (KO) of connexin43 (Cx43) was shown to be an effector of multiple histological changes in tubular morphology, resulting in germ cell loss through to a Sertoli-cell-only (SCO) phenotype and vacuolated seminiferous ...
Sarah Staggenborg +11 more
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Immunohistochemical Detection of Iron-Related Proteins in Sertoli Cell-Only Patterns in Canine Testicular Lesions [PDF]
AnimalsSertoli cell-only (SCO) tubules are a histologic pattern characterized by the absence of germ cells within seminiferous tubules, leading to infertility in both humans and dogs. While its association with testicular tumors has been documented, the role of
Rebecca Leandri +3 more
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Single-cell RNA sequencing uncovers abnormal Sertoli-cell elevation and testicular niche impairment in the transfemales’s testis [PDF]
Cell & BioscienceBackground Transgender women (transfemales) often undergo gender-affirming hormone therapy (GAHT). However, the testicular impacts of feminising hormones present heterogeneity due to the complexity of testicular regulatory mechanisms.
Jun Yu +14 more
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Chronic asymptomatic orchitis in dogs alters Sertoli cell number and maturation status [PDF]
Frontiers in Veterinary ScienceInfertility due to non-obstructive azoospermia is a common diagnosis in infertile male dogs. Chronic asymptomatic orchitis (CAO) has been postulated as a significant cause of non-obstructive azoospermia in acquired male canine infertility. Despite severe
Pauline Rehder +3 more
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Sertoli Cells - Methods and Protocols
European Journal of Histochemistry, 2019 The mammalian somatic cell providing the physiological milieu to germ cells growth and differentiation is the Sertoli cell, named after the Italian physiologist Enrico Sertoli.
CarloAlberto Redi
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scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia [PDF]
eLifeNon-obstructive azoospermia (NOA) belongs to male infertility due to spermatogenesis failure. However, evidence for cell type-specific abnormalities of spermatogenesis disorders in NOA remains lacking.
Shimin Wang +5 more
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Expression of NKX 3.1 in Sertoli Cell Tumors
Pakistan Armed Forces Medical Journal, 2022 Objective: To evaluate the NKX3.1 expression by immunohistochemistry in normal testicular parenchyma and in Sertoli cell tumours and Sertoli Leydig cell tumours of the testes and ovary. Study Design: Retrospective longitudinal study.
Arooj Fatima, Sajid Mushtaq, Asif Loya
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Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction. [PDF]
PLoS ONE, 2010 Sertoli cells, the support cells of mammalian spermatogenesis, are regulated by a number of nuclear factors and express retinoblastoma (RB) tumor suppressor protein.
Roopa L Nalam +2 more
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