Results 11 to 20 of about 26,105 (231)

Sertoli cell tumor in patient with multiple intratesticular cysts

Urology Case Reports, 2022
Sertoli cell tumor is a rare type of testicular tumor. In this study, a 70-year-old man was presented with a Sertoli cell tumor with non-classical findings. The patient noticed progressive swelling on the left hemiscrotum.
Farzad Allameh, Amir Alinejad Khorram, Seyyed Ali Hojjati, Negin Rastian   +3 more
doaj   +1 more source

E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice

Animals, 2020
In the mammalian testes, Sertoli cells are the only somatic cells in the seminiferous tubules that provide structural, nutritional and regulatory support for developing spermatogenic cells.
Rong-Ge Yan, Qi-Lin Yang, Qi-En Yang
doaj   +1 more source

Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. [PDF]

PLoS ONE, 2012
Post-natal testicular development is dependent on gonadotrophin and androgen stimulation. Follicle stimulating hormone (FSH) acts through receptors (FSHR) on the Sertoli cell to stimulate spermatogenesis while androgens promote testis growth through ...
Peter J O'Shaughnessy, Ana Monteiro, Margaret Abel   +2 more
doaj   +1 more source

The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation

Frontiers in Endocrinology, 2021
Sustaining and maintaining the intricate process of spermatogenesis is liable upon hormones and growth factors acting through endocrine and paracrine pathways.
Wasim Shah, Ranjha Khan, Basit Shah, Asad Khan, Sobia Dil, Wei Liu, Jie Wen, Xiaohua Jiang   +7 more
doaj   +1 more source

Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway

Frontiers in Pharmacology, 2020
Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting.
Haixia Zhao, Haixia Zhao, Xu You, Qian Chen, Qian Chen, Siqi Yang, Qiongyan Ma, Yumin He, Yumin He, Chaoqi Liu, Yaoyan Dun, Jie Wu, Changcheng Zhang, Changcheng Zhang, Ding Yuan   +14 more
doaj   +1 more source

RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells

Cell & Bioscience, 2023
Background Spermatogenesis depends on the supporting of the Sertoli cells and their communications with germ cells. However, the regulation of crosstalk between the Sertoli cells and germ cells remains unclear. Results In this report, we used conditional
Fengling Lai, Haoyu Wang, Xinyue Zhao, Kangning Yang, Le Cai, Mengxin Hu, Lan Lin, Xizhong Xia, Wei Li, Hanhua Cheng, Rongjia Zhou   +10 more
doaj   +1 more source

Sertoli Cell-Specific Activation of Transforming Growth Factor Beta Receptor 1 Leads to Testicular Granulosa Cell Tumor Formation

Cells, 2023
The transforming growth factor β (TGFβ) superfamily, consisting of protein ligands, receptors, and intracellular SMAD transducers, regulates fundamental biological processes and cancer development.
Xin Fang, Linfeng Nie, Satwikreddy Putluri, Nan Ni, Laurent Bartholin, Qinglei Li   +5 more
doaj   +1 more source

Dysregulation of Immature Sertoli Cell Functions by Exposure to Acetaminophen and Genistein in Rodent Cell Models

Cells, 2023
Sertoli cells are essential for germ cell development and function. Their disruption by endocrine disrupting chemicals (EDCs) or drugs could jeopardize spermatogenesis, contributing to male infertility. Perinatal exposure to EDCs and acetaminophen (APAP)
Maia Corpuz-Hilsabeck, Nicole Mohajer, Martine Culty   +2 more
doaj   +1 more source

THE EFFECT OF PREDNISONE ON SERTOLI CELL OF CONTRALATERAL TESTICULAR TORSION

Jurnal Urologi Indonesia, 2012
Objective: To evaluate the effect of prednisone in unilateral testicular torsion on Sertoli cell quality of contralateral testis. Material & Method: Thirty Wistar rats were divided into three groups i.e.
Dandy Tanuwidjaja, Suwandi Sugandi, Aaron Tigor Tigor Sihombing, Anglita Yantisetiasti, Betthy S. Hernowo   +4 more
doaj   +1 more source

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?

Frontiers in Endocrinology, 2022
Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
doaj   +1 more source