Immunohistochemical Detection of Iron-Related Proteins in Sertoli Cell-Only Patterns in Canine Testicular Lesions [PDF]
AnimalsSertoli cell-only (SCO) tubules are a histologic pattern characterized by the absence of germ cells within seminiferous tubules, leading to infertility in both humans and dogs. While its association with testicular tumors has been documented, the role of
Rebecca Leandri +3 more
doaj +2 more sources
Single-cell RNA sequencing uncovers abnormal Sertoli-cell elevation and testicular niche impairment in the transfemales’s testis [PDF]
Cell & BioscienceBackground Transgender women (transfemales) often undergo gender-affirming hormone therapy (GAHT). However, the testicular impacts of feminising hormones present heterogeneity due to the complexity of testicular regulatory mechanisms.
Jun Yu +14 more
doaj +2 more sources
Chronic asymptomatic orchitis in dogs alters Sertoli cell number and maturation status [PDF]
Frontiers in Veterinary ScienceInfertility due to non-obstructive azoospermia is a common diagnosis in infertile male dogs. Chronic asymptomatic orchitis (CAO) has been postulated as a significant cause of non-obstructive azoospermia in acquired male canine infertility. Despite severe
Pauline Rehder +3 more
doaj +2 more sources
Sertoli Cells - Methods and Protocols
European Journal of Histochemistry, 2019 The mammalian somatic cell providing the physiological milieu to germ cells growth and differentiation is the Sertoli cell, named after the Italian physiologist Enrico Sertoli.
CarloAlberto Redi
doaj +4 more sources
scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia [PDF]
eLifeNon-obstructive azoospermia (NOA) belongs to male infertility due to spermatogenesis failure. However, evidence for cell type-specific abnormalities of spermatogenesis disorders in NOA remains lacking.
Shimin Wang +5 more
doaj +2 more sources
Expression of NKX 3.1 in Sertoli Cell Tumors
Pakistan Armed Forces Medical Journal, 2022 Objective: To evaluate the NKX3.1 expression by immunohistochemistry in normal testicular parenchyma and in Sertoli cell tumours and Sertoli Leydig cell tumours of the testes and ovary. Study Design: Retrospective longitudinal study.
Arooj Fatima, Sajid Mushtaq, Asif Loya
doaj +1 more source
Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction. [PDF]
PLoS ONE, 2010 Sertoli cells, the support cells of mammalian spermatogenesis, are regulated by a number of nuclear factors and express retinoblastoma (RB) tumor suppressor protein.
Roopa L Nalam +2 more
doaj +1 more source
Sertoli cell tumor in patient with multiple intratesticular cysts
Urology Case Reports, 2022 Sertoli cell tumor is a rare type of testicular tumor. In this study, a 70-year-old man was presented with a Sertoli cell tumor with non-classical findings. The patient noticed progressive swelling on the left hemiscrotum.
Farzad Allameh +3 more
doaj +1 more source
Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. [PDF]
PLoS ONE, 2012 Post-natal testicular development is dependent on gonadotrophin and androgen stimulation. Follicle stimulating hormone (FSH) acts through receptors (FSHR) on the Sertoli cell to stimulate spermatogenesis while androgens promote testis growth through ...
Peter J O'Shaughnessy +2 more
doaj +1 more source
The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation
Frontiers in Endocrinology, 2021 Sustaining and maintaining the intricate process of spermatogenesis is liable upon hormones and growth factors acting through endocrine and paracrine pathways.
Wasim Shah +7 more
doaj +1 more source