Frontiers in Endocrinology, 2022 Since their initial description by Enrico Sertoli in 1865, Sertoli cells have continued to enchant testis biologists. Testis size and germ cell carrying capacity are intimately tied to Sertoli cell number and function.
Victor A. Ruthig +3 more
doaj +3 more sources
Sertoli Cells Enhance Formation of Capillary-Like Structures in Vitro
Cell Transplantation, 2008 Sertoli cells isolated from the testis (referred to as extratesticular Sertoli cells) have been shown to facilitate allo- and xenogeneic cell transplantations.
Brian T. Golat, Don F. Cameron Ph.D.
doaj +2 more sources
Scientific Reports, 2022 The Sertoli cell (SC)-specific knockout (KO) of connexin43 (Cx43) was shown to be an effector of multiple histological changes in tubular morphology, resulting in germ cell loss through to a Sertoli-cell-only (SCO) phenotype and vacuolated seminiferous ...
Sarah Staggenborg +11 more
doaj +3 more sources
E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice [PDF]
Animals, 2020 In the mammalian testes, Sertoli cells are the only somatic cells in the seminiferous tubules that provide structural, nutritional and regulatory support for developing spermatogenic cells.
Rong-Ge Yan, Qi-Lin Yang, Qi-En Yang
doaj +2 more sources
RU 486 blocks inhibitory effect of neonatal corticosterone administration on sertoli cell proliferation in mice [PDF]
Scientific ReportsCortisol/corticosterone (CORT) are typical glucocorticoids and exert an anti-stress function. p27, a cyclin-dependent kinase inhibitor, acts as a terminal factor for Sertoli cell proliferation at the prepubescent stage. Our previous study showed neonatal
Hidenobu Miyaso +10 more
doaj +2 more sources
Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation
Frontiers in Endocrinology, 2019 Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited number of germ cells, the final number of Sertoli cells reached ...
Silvina Beatriz Meroni +5 more
doaj +3 more sources
Immunohistochemical Detection of Iron-Related Proteins in Sertoli Cell-Only Patterns in Canine Testicular Lesions [PDF]
AnimalsSertoli cell-only (SCO) tubules are a histologic pattern characterized by the absence of germ cells within seminiferous tubules, leading to infertility in both humans and dogs. While its association with testicular tumors has been documented, the role of
Rebecca Leandri +3 more
doaj +2 more sources
Inhibition of miR-143-3p Restores Blood–Testis Barrier Function and Ameliorates Sertoli Cell Senescence [PDF]
CellsDue to the increasing trend of delayed childbirth, the age-related decline in male reproductive function has become a widely recognized issue. Sertoli cells (SCs) play a vital role in creating the necessary microenvironment for spermatogenesis in the ...
Ziyan Xiao +11 more
doaj +2 more sources
scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia [PDF]
eLifeNon-obstructive azoospermia (NOA) belongs to male infertility due to spermatogenesis failure. However, evidence for cell type-specific abnormalities of spermatogenesis disorders in NOA remains lacking.
Shimin Wang +5 more
doaj +2 more sources
Expression of NKX 3.1 in Sertoli Cell Tumors
Pakistan Armed Forces Medical Journal, 2022 Objective: To evaluate the NKX3.1 expression by immunohistochemistry in normal testicular parenchyma and in Sertoli cell tumours and Sertoli Leydig cell tumours of the testes and ovary. Study Design: Retrospective longitudinal study.
Arooj Fatima, Sajid Mushtaq, Asif Loya
doaj +1 more source