Results 111 to 120 of about 33,143 (262)

Cellular and hormonal disruption of fetal testis development in sheep reared on pasture treated with sewage sludge

, 2005
The purpose of this study was to evaluate whether experimental exposure of pregnant sheep to a mixture of environmental chemicals added to pasture as sewage sludge (n = 9 treated animals) exerted effects on fetal testis development or function ...
Paul, Catriona, Kyle, Carol E, McKinnell, Chris, Sharpe, Richard M, Catriona Paul, Richard M. Sharpe, Hayley Scott, Chris McKinnell, Scott, Hayley, Rhind, Stewart M, Carol E. Kyle, Stewart M. Rhind   +11 more
core   +1 more source

expression in 15P‐1 Sertoli cells

, 2023
In Sertoli cells of the testis, cadherins (Cdh) are important cell-to-cell interaction proteins and contribute to the formation of the blood-testis barrier being essential for germ cells' protection.
Martin, Luc J., Nguyen, Ha T., Luc J. Martin, Ha T. Nguyen   +3 more
core   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source

Unique Sertoli cell adaptations support enhanced spermatogenesis in chickens

Journal of Animal Science and Biotechnology
Background The cellular basis of testicular development and spermatogenesis for the extreme sperm density in chickens (100-fold higher than mammals) remains poorly defined.
Gaoqing Xu, Zhuoxuan Gu, Ziming Wang, Jing Zhao, He Ding, Hongyu Liu, Yi Fang, Xin Ma, Jing Guo, Wenfa Lyu, Jun Wang   +10 more
doaj   +1 more source

Characterization of chicken Sertoli cells in vitro

, 2011
In the testis, Sertoli cells play a key physiological role in that they support, nourish, and protect germ cells. Because of the importance of Sertoli cells, several laboratories have established a culture system of Sertoli cells.
J.P. Brillard, S. Brière, Brière, Sylvain, Brillard, Jean-Pierre, R. Pelletier, Guibert, Edith, Pelletier, R., Froment, Pascal, E. Guibert, P. Froment   +9 more
core   +1 more source

Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse [PDF]

, 2009
Follicle stimulating hormone (FSH) acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis we have treated gonadotrophin-deficient hypogonadal (hpg ...
Abel, M.H., Lee, S., Charlton, H.M., O'Shaughnessy, P.J., Baban, D.   +4 more
core   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Unveiling the roles of Sertoli cells lineage differentiation in reproductive development and disorders: a review

Frontiers in Endocrinology
In mammals, gonadal somatic cell lineage differentiation determines the development of the bipotential gonad into either the ovary or testis. Sertoli cells, the only somatic cells in the spermatogenic tubules, support spermatogenesis during gonadal ...
Yang Gao, Zican Wang, Yue Long, Lici Yang, Yongjian Jiang, Dongyu Ding, Baojian Teng, Min Chen, Jinxiang Yuan, Jinxiang Yuan, Fei Gao, Fei Gao, Fei Gao   +12 more
doaj   +1 more source