Results 141 to 150 of about 33,143 (262)
Envolvimento de canais de K+ e vias dependentes de Ca++ no efeito estimulatório do T3 no transporte de aminoácidos em testículos de ratos imaturos [PDF]
, 2002 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.
Volpato, Karine Cunha
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Menopausal hormone therapy after ovarian cancer: A 10‐year survival analysis in premenopausal women
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.Among premenopausal women surgically treated for ovarian cancer, no difference in 10‐year overall survival was observed between postoperative MHT users and non‐users. Young ovarian cancer survivors should be recommended MHT after surgically induced menopause.
Åsa Ehlin von Kartaschew +4 more
wiley +1 more source
MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy
Cancer Science, EarlyView.MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley +1 more source
Sertoli Cells - Methods and Protocols
European Journal of Histochemistry, 2019 The mammalian somatic cell providing the physiological milieu to germ cells growth and differentiation is the Sertoli cell, named after the Italian physiologist Enrico Sertoli. Sertoli described for the first time this functionally multitasking cell in 1865 (when he was 23 years-old!) in human testicular tissues while ending up his medicine studies at ...
openaire +4 more sources
Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome
Clinical Endocrinology, EarlyView.ABSTRACT Context Klinefelter syndrome (KS), defined by a 47, XXY karyotype, is commonly associated with progressive testicular failure. The precise timing of Sertoli and Leydig cell dysfunction during puberty remains unclear. Objective To determine the onset and progression of testicular insufficiency during puberty in KS, and to assess whether ...
Tredez Axelle +9 more
wiley +1 more source
The FEBS Journal, EarlyView.Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre +2 more
wiley +1 more source
Unilateral ductus deferens aplasia with terminal cystic dilation in a Bernese mountain dog
Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.Abstract An incidental caudal abdominal mass was discovered in a 5‐year‐old, male, entire Bernese mountain dog. Investigations showed a terminal cystic dilation of the left ductus deferens. Castration, along with surgical resection of the mass, was performed, and histopathology of the mass and ductus deferens was consistent with segmental aplasia of ...
Daisy Johnson +3 more
wiley +1 more source
50 years of spermatogenesis: Sertoli cells and their interactions with germ cells
, 2018 The complex morphology of the Sertoli cells and their interactions with germ cells has been a focus of investigators since they were first described by Enrico Sertoli. In the past 50 years, information on Sertoli cells has transcended morphology alone to
Michael D Griswold, Griswold, Michael D
core +1 more source
Cryptorchidism: Novel genetic insights into CCDC149 mutations
Andrology, Volume 14, Issue 5, Page 1155-1163, July 2026.Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du +8 more
wiley +1 more source
Interactions between Sertoli cells and germ cells in the testis
, 1994 The production of mature spermatozoa requires a complex interaction between Sertoli cells and germ cells. Sertoli cells regulate aspects of germ cell division and differentiation while germ cells provide signals that modulate Sertoli cell functions. Germ
Griswold, M. P., McGuinness, Michael P.
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