Results 141 to 150 of about 4,451,677 (265)

HMGA2 is a highly sensitive marker for DICER1‐related tumours

Histopathology, EarlyView.
Aims DICER1 is a microRNA biogenesis enzyme that, when mutated, results in a rewiring of the transcriptome. Germline pathogenic variants (PVs) in DICER1 result in DICER1‐related tumour predisposition (DRTP) characterized by 30 or more different, generally rare, paediatric or adolescent‐onset tumours.
Paul S. Thorner, Anne‐Laure Chong, Naciba Benlimane, Lili Fu, Marc R. Fabian, William D. Foulkes   +5 more
wiley   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Rapidly Progressive Metastatic Sertoli Cell Tumor Associated With an Adenomatous Polyposis Coli Mutation: A Case Report and Literature Review

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Sertoli cell tumors are rare testicular sex cord‐stromal tumors, and clinically malignant behavior is uncommon. We report a rapidly progressive metastatic Sertoli cell tumor associated with an APC mutation. Case Presentation A 27‐year‐old man with familial adenomatous polyposis (FAP) presented with painless right scrotal ...
Kotaro Obayashi, Mika Terasaki, Hiroya Hasegawa, Hikaru Mikami, Masato Yanagi, Hayato Takeda, Yuki Endo, Yuka Toyama, Ryuji Ohashi, Jun Akatsuka   +9 more
wiley   +1 more source

Histological Findings in Testes of Baboons (Papio spp.) and Dwarf Bucks (Capra hircus) Subject to Repeated Immunisation Against GnRH

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Long‐term repeated immunisation against GnRH resulted in the absence of active spermatogenesis and may lead to irreversible infertility in dwarf bucks and baboons. Histological examination revealed a marked reduction of the seminiferous tubular lumen, complete depletion of germ cells, germ cell vacuolization and tubular hyalinization.
Teresa Ferrín, Eva Martínez‐Nevado, Juncal García, Adolfo Toledano‐Díaz, Rosario Velázquez, Esther Alba, Cristina Castaño, Belén Martinez‐Madrid, Julián Santiago‐Moreno   +8 more
wiley   +1 more source

The interaction between Sertoli cells and luekemia inhibitory factor on the propagation and differentiation of spermatogonial stem cells in vitro

Iranian Journal of Reproductive Medicine, 2015
Background: Sertoli cells play a pivotal role in creating microenvironments essential for spermatogonial stem cells (SSCs) self-renewal and commitment to differentiation.
Tayebeh Rastegar, Mehryar Habibi Roudkenar, Soraya Parvari, Maryam Baazm   +3 more
doaj  

Seminal Plasma Exosomal miRNA Profiling Reveals hsa‐miR‐7‐5p as a Key Regulator of Sperm Motility in Asthenozoospermia

Andrology, Volume 14, Issue 7, Page 2166-2179, October 2026.
ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu, Meng‐Li Cui, Wen‐Jing Yuan, Jia‐Ning Zhang, Shuo Zhang, Xi‐Qiao Yao, Ruo‐Qing Li, Jin‐Feng Li, En‐Zhong Li   +8 more
wiley   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, Volume 14, Issue 7, Page 2329-2346, October 2026.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Hormonal Therapy Before Micro‐TESE in Men With Nonobstructive Azoospermia: A Negative Answer to an Overly Broad Question

Andrology, EarlyView.
Sandro C. Esteves, Arnold P. P. Achermann, Ricardo Miyaoka, Cassio L. Z. Riccetto, Adriano Fregonesi   +4 more
wiley   +1 more source

Boosting Male Fertility: The Impact of Gonadotropin Therapy on Hypogonadotropic Hypogonadism—A Systematic Review and Meta‐Analysis

Andrology, Volume 14, Issue 7, Page 1971-1987, October 2026.
ABSTRACT Background Male hypogonadotropic hypogonadism typically presents with azoospermia and is one of the few causes of infertility amenable to a medical intervention. Gonadotropin therapy offers a chance to restore spermatogenesis and fertility in these individuals.
Manou Huijben, Anne Prinsen, Laetitia de Kort, Jetske van Breda   +3 more
wiley   +1 more source

Androgen rapidly activates phosphorylation signaling pathways in Sertoli cells. [PDF]

Exp Ther Med
Sun R, Du Y, Gao L, Wang Z, Liang H, Zhang Y, Deng Q.   +6 more
europepmc   +1 more source